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Investigation of serum endocan and serglycin levels in obstructive sleep apnea

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Abstract

Background

Apnea-related hypoxia, hypercapnia, and blood pressure fluctuations cause production of various proinflammatory cytokines and trigger a vicious cycle that results in vascular endothelial damage and systemic inflammation in obstructive sleep apnea (OSA). Endothelial function is frequently impaired in OSA even in the absence of significant cardiac or vascular disorders.

Aims

This study aimed to investigate the serum endocan and serglycin levels in OSA patients.

Methods

This prospective study included 78 consecutive patients who admitted to the sleep laboratory of a tertiary referral center with the complaints of daytime sleepiness, witnessed sleep apnea, and/or snoring and who underwent all-night polysomnography (PSG). After PSG, the patients were divided into four groups in relation with their apnea–hypopnea indexes. The groups were compared for endocan and serglycin levels and their correlations with OSA severity. The correlations with demographic data and PSG findings were also investigated.

Results

The OSA and the control groups had significantly different endocan and serglycin levels (\(p = 0.001\), for both). On univariate logistic regression analysis, it was found that serglycin and endocan levels and BMI were predictors of OSA. Multiple logistic regression analysis showed that endocan and serglycin levels were independent predictors for OSA (\(p = 0.027\) and \(p = 0.003\), respectively).

Conclusions

We have demonstrated that elevated endocan and serglycin levels are predictors for OSA. Furthermore, we have showed for the first time in literature that serglycin is correlated with OSA and is an independent predictor for OSA.

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Data availability

The datasets used and/or analyzed during the current study are available from the corresponding author on reasonable request.

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Author information

Authors and Affiliations

  1. Department of Otorhinolaryngology, Ankara City Hospital, Ankara, Turkey

    Rauf Oguzhan Kum & Fatma Cemre Sazak Kundi

  2. Department of Biochemistry, Ankara City Hospital, Ankara, Turkey

    Canan Topcuoglu

  3. Private Clinic, Ankara, Turkey

    Muge Ozcan

Authors
  1. Rauf Oguzhan Kum
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  2. Fatma Cemre Sazak Kundi
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  3. Canan Topcuoglu
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  4. Muge Ozcan
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Contributions

All authors contributed to the study conception and design. Material and method preparation were performed by R.O.K., F.C.S.K., and C.T. Data collection and analysis were performed by R.O.K. and C.T. Statistical analysis and interpretation were performed by R.O.K. All the authors contributed to writing and read and approved the final version of the manuscript.

Corresponding author

Correspondence to Rauf Oguzhan Kum.

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Ethical approval

Our study was approved by the local ethics committee and conducted in accordance with the ethical principles described by the Declaration of Helsinki (Project No. E16-933).

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Informed consent was obtained from all individual participants included in the study.

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The authors declare no competing interests.

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Kum, R.O., Sazak Kundi, F.C., Topcuoglu, C. et al. Investigation of serum endocan and serglycin levels in obstructive sleep apnea. Ir J Med Sci 192, 2909–2915 (2023). https://doi.org/10.1007/s11845-023-03360-3

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  • DOI: https://doi.org/10.1007/s11845-023-03360-3

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