Skip to main content

Advertisement

SpringerLink
Log in

Optic neuropathy in spaceflight-associated neuro-ocular syndrome (SANS)

  • Letter to the Editor
  • Published:
Irish Journal of Medical Science (1971 -) Aims and scope Submit manuscript

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

References

  1. Waisberg E, Ong J, Paladugu P et al (2022) Challenges of Artificial Intelligence in Space Medicine. Space: Sci Technol 1–7. https://spj.sciencemag.org/journals/space/2022/9852872/. https://doi.org/10.34133/2022/9852872. Accessed 30 Oct  2022 

  2. Lee AG, Mader TH, Gibson CR et al (2018) Space flight-associated neuro-ocular syndrome (SANS). Eye 32(7):1164. https://doi.org/10.1038/s41433-018-0070-y

    Article  PubMed  PubMed Central  Google Scholar 

  3. Mader TH, Taylor GR, Hunter N et al (1990) Intraocular pressure, retinal vascular, and visual acuity changes during 48 hours of 10 degrees head-down tilt. Aviat Space Environ Med 61(9):810–813

    CAS  PubMed  Google Scholar 

  4. Shinojima A, Iwasaki K, Aoki K et al (2012) Subfoveal Choroidal Thickness and Foveal Retinal Thickness During Head-Down Tilt. Aviat Space Environ Med 83(4):388–393. https://doi.org/10.3357/ASEM.3191.2012

    Article  PubMed  Google Scholar 

  5. Chiquet C, Custaud M-A, Le Traon AP et al (2003) Changes in Intraocular Pressure during Prolonged (7-Day) Head-Down Tilt Bedrest. J Glaucoma 12(3):204

    Article  PubMed  Google Scholar 

  6. Miller NR, Arnold AC (2015) Current concepts in the diagnosis, pathogenesis and management of nonarteritic anterior ischaemic optic neuropathy. Eye 29(1):65–79. https://doi.org/10.1038/eye.2014.144

    Article  CAS  PubMed  Google Scholar 

  7. Lessell S (1999) Nonarteritic Anterior Ischemic Optic Neuropathy: Enigma Variations. Arch Ophthalmol 117(3):386–388. https://doi.org/10.1001/archopht.117.3.386

    Article  CAS  PubMed  Google Scholar 

  8. Nagia L, Huisingh C, Johnstone J et al (2016) Peripapillary Pachychoroid in Nonarteritic Anterior Ischemic Optic Neuropathy. Invest Ophthalmol Vis Sci 57(11):4679–4685. https://doi.org/10.1167/iovs.16-19315

    Article  PubMed  PubMed Central  Google Scholar 

  9. Feola AJ, Girkin CA, Ethier CR, Samuels BC (2022) A Potential Role of Acute Choroidal Expansion in Nonarteritic Anterior Ischemic Optic Neuropathy. Investig Opthalmol & Vis Sci 63(4):23. https://iovs.arvojournals.org/article.aspx?articleid=2778784. https://doi.org/10.1167/iovs.63.4.23. Accessed 19 Feb  2023 

  10. Cestari DM, Gaier ED, Bouzika P et al (2016) Demographic, Systemic, and Ocular Factors Associated with Nonarteritic Anterior Ischemic Optic Neuropathy. Ophthalmology 123(12):2446–2455. https://linkinghub.elsevier.com/retrieve/pii/S0161642016309149. https://doi.org/10.1016/j.ophtha.2016.08.017. Accessed 19 Feb 2023

  11. Diedrich A, Paranjape SY, Robertson D (2007) Plasma and Blood Volume in Space. Ame J Med Sci 334(1):80–86. https://linkinghub.elsevier.com/retrieve/pii/S0002962915325416. https://doi.org/10.1097/MAJ.0b013e318065b89b. Accessed 24 Feb 2023

  12. Fu Q, Shibata S, Hastings JL et al (2019) Impact of Prolonged Spaceflight on Orthostatic Tolerance During Ambulation and Blood Pressure Profiles in Astronauts. Circulation 140(9):729–738. https://www.ahajournals.org/doi/10.1161/CIRCULATIONAHA.119.041050. https://doi.org/10.1161/CIRCULATIONAHA.119.041050. Accessed 19 Feb  2023

  13. Hamilton HE, Ellis PP, Sheets RF (1959) Visual Impairment due to Optic Neuropathy in Pernicious Anemia: Report of a Case and Review of the Literature. Blood 14(4):378–385. https://ashpublications.org/blood/article/14/4/378/37213/Visual-Impairment-due-to-Optic-Neuropathy-in. https://doi.org/10.1182/blood.V14.4.378.378. Accessed 27 Feb 2023

  14. Yu CW, Waisberg E, Kwok JM, Micieli JA (2022) Anemia and Idiopathic Intracranial Hypertension: A Systematic Review and Meta-analysis. J Neuro-Ophthalmol 42(1):e78–e86. https://journals.lww.com/10.1097/WNO.0000000000001408. https://doi.org/10.1097/WNO.0000000000001408. Accessed 13 Mar 2022

  15. Waisberg E, Yu CW, Sverdlichenko I, Micieli JA (2021) New Onset Severe Anemia and Fulminant Idiopathic Intracranial Hypertension. Can J Neurol Sci / J Can des Sci Neurol 1–3. https://www.cambridge.org/core/product/identifier/S0317167121002031/type/journal_article. https://doi.org/10.1017/cjn.2021.203. Accessed 2 Apr 2022

  16. Brouzas D, Charakidas A, Ladas I, Apostolopoulos M (2009) Nonarteritic anterior ischemic optic neuropathy associated with chronic anemia: a case series of myelodysplastic syndrome patients. Clin Ophthalmol (Auckland, N.Z.). 3:133–137

  17. Waisberg E, Ong J, Zaman N et al (2022) A non-invasive approach to monitor anemia during long-duration spaceflight with retinal fundus images and deep learning. Life Sci Space Res 33:69–71. https://linkinghub.elsevier.com/retrieve/pii/S2214552422000189. https://doi.org/10.1016/j.lssr.2022.04.004. Accessed 6 May 2022

  18. Trudel G, Shahin N, Ramsay T et al (2022) Hemolysis contributes to anemia during long-duration space flight. Nat Med 28(1):59–62. https://www.nature.com/articles/s41591-021-01637-7. https://doi.org/10.1038/s41591-021-01637-7. Accessed 26 Feb 2022

  19. Zwart SR, Gibson CR, Mader TH et al (2012) Vision Changes after Spaceflight Are Related to Alterations in Folate– and Vitamin B-12–Dependent One-Carbon Metabolism. J Nutr 142(3):427–431. https://doi.org/10.3945/jn.111.154245

    Article  CAS  PubMed  Google Scholar 

  20. Zwart SR, Gregory JF, Zeisel SH et al (2016) Genotype, B-vitamin status, and androgens affect spaceflight-induced ophthalmic changes. FASEB J 30(1):141–148. https://doi.org/10.1096/fj.15-278457. Epub 2015 Aug 27. PMID: 26316272; PMCID: PMC4684521

  21. Ong J, Tavakkoli A, Zaman N et al (2022) Terrestrial health applications of visual assessment technology and machine learning in spaceflight associated neuro-ocular syndrome. npj Microgravity 8(1):37. https://www.nature.com/articles/s41526-022-00222-7. https://doi.org/10.1038/s41526-022-00222-7. Accessed 25 Aug 2022

  22. Waisberg E, Ong J, Zaman N et al (2022) Head-Mounted Dynamic Visual Acuity for G-Transition Effects During Interplanetary Spaceflight: Technology Development and Results from an Early Validation Study. Aerosp Med Hum Perform 93(11):800–805. https://www.ingentaconnect.com/content/10.3357/AMHP.6092.2022. https://doi.org/10.3357/AMHP.6092.2022. Accessed 10 Nov 2022

Download references

Author information

Authors and Affiliations

  1. University College Dublin School of Medicine, Belfield, Dublin 4, Ireland

    Ethan Waisberg & Mouayad Masalkhi

  2. Michigan Medicine, University of Michigan, Ann Arbor, USA

    Joshua Ong

  3. Center for Space Medicine, Baylor College of Medicine, Houston, TX, USA

    Andrew G. Lee

  4. Department of Ophthalmology, Blanton Eye Institute, Houston Methodist Hospital, Houston, TX, USA

    Andrew G. Lee

  5. The Houston Methodist Research Institute, Houston Methodist Hospital, Houston, TX, USA

    Andrew G. Lee

  6. Departments of Ophthalmology, Neurology, and Neurosurgery, Weill Cornell Medicine, New York, NY, USA

    Andrew G. Lee

  7. Department of Ophthalmology, University of Texas Medical Branch, Galveston, TX, USA

    Andrew G. Lee

  8. University of Texas MD Anderson Cancer Center, Houston, TX, USA

    Andrew G. Lee

  9. Texas A&M College of Medicine, Bryan, TX, USA

    Andrew G. Lee

  10. Department of Ophthalmology, The University of Iowa Hospitals and Clinics, Iowa City, IA, USA

    Andrew G. Lee

Authors
  1. Ethan Waisberg
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Joshua Ong
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Mouayad Masalkhi
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Andrew G. Lee
    View author publications

    You can also search for this author in PubMed Google Scholar

Contributions

E.W.: conceptualization and writing. J.O.: conceptualization and writing. M.M.: conceptualization and writing. A.G.L.: review and intellectual support.

Corresponding author

Correspondence to Ethan Waisberg.

Ethics declarations

Conflict of interest

The authors declare no conflict of interest.

Additional information

Publisher's Note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Waisberg, E., Ong, J., Masalkhi, M. et al. Optic neuropathy in spaceflight-associated neuro-ocular syndrome (SANS). Ir J Med Sci 192, 3143–3145 (2023). https://doi.org/10.1007/s11845-023-03353-2

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s11845-023-03353-2

Keywords

Search

Navigation