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Association between liver enzymes and metabolic syndrome: results of the enrollment phase of Tabari cohort

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Abstract

Background

The association between liver enzymes and metabolic syndrome (MetS) has been evaluated in several studies with different results. The purpose of this study is to determine the association between the serum levels of these liver enzymes and MetS in Tabari cohort population.

Method

In this case–control study, data collected from the enrolment phase of the Tabari cohort population have been used. MetS was defined based on IDF (international diabetes federation) standards. Then, 476 patients with MetS (case group) and 476 age-sex matched controls were selected randomly.

Results

Mean aspartate aminotransferase (AST) and alanine aminotransferase (ALT) levels were higher in case group than control group (20.59 vs. 19.99 respectively, p = 0.339 and 24.64 vs. 20.16 respectively, p < 0.001). The chance of having MetS, high triglyceride, and fasting blood glucose (FBG) was significantly higher in people with ALT ≥ 40 (1.63, 2.35, and 2.02, respectively). The chance of having MetS in people with AST ≥ 40 was 1.45 times higher than that among those with normal AST level (p > 0.05).

Conclusion

This study showed that there is an association between liver enzymes and MetS as well as some of its components. Liver enzymes, especially ALT, can be used as an early indicator of MetS in the at risk population

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Data Availability

The datasets used and/or analysed during the current study are available from the corresponding author on reasonable request. 

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Acknowledgements

We would like to thank all the members of PERSIAN cohort study (Ministry of Health and Medical Education and Mazandaran University of Medical Sciences) for all they did for PERSIAN cohort program.

Funding

This study was supported by Iranian Ministry of Health (grant number: 700/534) and research deputy of Mazandaran University of Medical Science (grant number: 2524).

Author information

Authors and Affiliations

  1. Diabetes Research Center, Mazandaran University of Medical Sciences, Sari, Iran

    Parastoo Karimi Aliabadi, Mehrnoush Sohrab & Zahra Kashi

  2. Student Research Committee, Faculty of Medicine, Mazandaran University of Medical Sciences, Sari, Iran

    Amirhossein Hessami

  3. Pediatric Gastroenterology and Hepatology Research Center, Zabol University of Medical Sciences, Zabol, Iran

    Mahdi Afshari

  4. Health Sciences Research Center, Addiction Institute, Mazandaran University of Medical Sciences, Sari, Iran

    Motahareh Kheradmand

  5. Gastrointestinal Cancer Research Center, Mazandaran University of Medical Sciences, Sari, Iran

    Akbar Hedayatizadeh-Omran, Reza Alizadeh-Navaei & Mahmood Moosazadeh

Authors
  1. Parastoo Karimi Aliabadi
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  2. Mehrnoush Sohrab
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  3. Amirhossein Hessami
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  4. Mahdi Afshari
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  5. Zahra Kashi
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  6. Motahareh Kheradmand
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  7. Akbar Hedayatizadeh-Omran
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  8. Reza Alizadeh-Navaei
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  9. Mahmood Moosazadeh
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Contributions

MK, MA, MS, and MM acquired data, performed the statistical analyses, interpreted data, and drafted and revised the manuscript for important intellectual content and approved the final version. PKA, AH, ZK, AH, and RA interpreted data, reviewed the analyses, and approved the final version.

Corresponding author

Correspondence to Mahmood Moosazadeh.

Ethics declarations

Ethics approval

Tabari cohort study was approved by Mazandaran University of Medical science ethical committee (IR.MAZUMS. REC.1395.2524). Also, written informed consent was obtained from all participants.

Competing interests

The authors declare no competing interests.

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Aliabadi, P.K., Sohrab, M., Hessami, A. et al. Association between liver enzymes and metabolic syndrome: results of the enrollment phase of Tabari cohort. Ir J Med Sci 191, 1201–1208 (2022). https://doi.org/10.1007/s11845-021-02694-0

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  • DOI: https://doi.org/10.1007/s11845-021-02694-0

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