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Renal transplantation outcomes following heart and heart–lung transplantation

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Irish Journal of Medical Science (1971 -) Aims and scope Submit manuscript

Abstract

Background

Chronic kidney disease is a frequent complication following heart and combined heart–lung transplantation. The aim of this study was to analyse the outcome of a subsequent renal transplant in heart, lung and heart–lung transplantation recipients.

Methods

All heart, lung and heart–lung transplant recipients who received a subsequent renal transplant over a 27-year period in a national heart and lung transplant centre were included in this study.

Results

A total of 18 patients who had previously undergone heart (n = 6), lung (n = 7) and heart–lung (n = 5) transplantation received a renal transplant. The mean duration to development of end-stage kidney disease (ESKD) was 115 ± 45.9 months. The most common contributor to ESKD was calcineurin inhibitor nephrotoxicity. The 5-year patient survival and graft survival rates were 91.7 and 85.6%, respectively. The median creatinine level at the most recent follow-up was 123 μmol/L, IQR 90.8–147.5.

Conclusions

The overall outcome of renal transplantation following previous non-renal solid organ transplantation is excellent considering the medical complexity and co-morbidities of this patient population. Renal transplantation represents an important treatment option for ESKD in non-renal solid organ transplant recipients.

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Authors and Affiliations

  1. Department of Nephrology, Mater Misericordiae University Hospital, Eccles Street, Dublin 7, Ireland

    L. Wong, D. M. Sadlier & Y. M. O’Meara

  2. Department of Cardiothoracic Surgery, Mater Misericordiae University Hospital, Dublin, Ireland

    Y. R. Chee & D. G. Healy

  3. Department of Respiratory Medicine, Mater Misericordiae University Hospital, Dublin, Ireland

    J. J. Egan

Authors
  1. L. Wong
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  2. Y. R. Chee
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  3. D. G. Healy
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  4. J. J. Egan
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  5. D. M. Sadlier
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  6. Y. M. O’Meara
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Corresponding author

Correspondence to L. Wong.

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Funding

We have no funding sources for this study.

Conflict of interest

The authors declare no conflicts of interest.

Ethical approval

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

Informed consent

Informed consent from all individual participants included in the study was waived due to the retrospective nature of the study.

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Wong, L., Chee, Y.R., Healy, D.G. et al. Renal transplantation outcomes following heart and heart–lung transplantation. Ir J Med Sci 186, 1027–1032 (2017). https://doi.org/10.1007/s11845-016-1550-3

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  • DOI: https://doi.org/10.1007/s11845-016-1550-3

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