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Comparison of arterial stiffness and microcirculatory changes following abdominal aortic aneurysm grafting

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Abstract

Backgound

Abdominal aortic aneurysm (AAA) surgery provides a unique opportunity to study the impact of arterial stiffness on central haemodynamics, reflected in augmentation index (AI). The aneurysmal aorta is significantly stiffer than undilated age-matched aorta.

Aim

We investigated whether replacement of an aneurysmal aorta with a compliant graft would result in a decrease in AI, which would thus decrease myocardial workload parameters.

Methods

Patients undergoing elective open or endovascular AAA repair were assessed with applanation tonometry and laser fluximetry pre-operatively, immediately and long-term post-operatively.

Results

Replacement of a small segment of abnormal conduit vessel resulted in improvements in AI, demonstrating that arterial stiffness can be surgically manipulated.

Conclusions

These results reflect a decreased myocardial workload post-aortic grafting. This decrease in AI is important from a risk factor management perspective, and arterial stiffness should become a further recognised and screened for risk factor in patients with known aneurysmal disease.

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Authors and Affiliations

  1. Department of Vascular Surgery, Beaumont Hospital, Beaumont Road, Beaumont, Dublin 9, Ireland

    M. A. Moloney, S. McHugh, D. H. O’ Donnell, R. G. Casey, E. G. Kavanagh, P. A. Grace, P. Fitzgerald & D. J. Bouchier-Hayes

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  1. M. A. Moloney
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  2. S. McHugh
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  3. D. H. O’ Donnell
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  4. R. G. Casey
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  5. E. G. Kavanagh
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  6. P. A. Grace
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  7. P. Fitzgerald
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  8. D. J. Bouchier-Hayes
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Correspondence to M. A. Moloney.

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Moloney, M.A., McHugh, S., O’ Donnell, D.H. et al. Comparison of arterial stiffness and microcirculatory changes following abdominal aortic aneurysm grafting. Ir J Med Sci 180, 375–378 (2011). https://doi.org/10.1007/s11845-010-0513-3

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  • DOI: https://doi.org/10.1007/s11845-010-0513-3

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