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Chronobiologische Aspekte der Insomnie

Chronobiological components of insomnia

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Zusammenfassung

Für das Verständnis von Ein- und Durchschlafstörungen sind Erkenntnisse der chronobiologischen Forschung wichtig. Ein Teil der Patient*innen, die unter einer Insomnie leiden, weist Auffälligkeiten in der zirkadianen Rhythmik der Körpertemperatur sowie der Melatoninausschüttung auf. Diese Auffälligkeiten stehen im Zusammenhang mit Einschlafbeschwerden und frühem Erwachen. Chronobiologische Therapien zielen auf eine Synchronisation der zirkadianen Rhythmen ab, wobei die Evidenzlage für die Wirksamkeit dieser Verfahren im Kontext der Insomnie weitgehend unklar ist. Es sollte weiterhin überprüft werden, inwiefern sich die Kognitive Verhaltenstherapie für Insomnie auf chronobiologische Faktoren auswirken könnte.

Abstract

In order to better understand sleep initiation and maintenance disorders research into human chronobiology is necessary. Some patients suffering from insomnia seem to show abnormal circadian rhythms of core body temperature and melatonin onset. These circadian rhythm angles are associated with difficulties falling asleep and with complaints of early morning awakenings. Chronobiological treatments aim to enhance appropriately timed input to the circadian timing system to support its role in sleep regulation. Nevertheless, the evidence of their effects remains unclear in patients with insomnia. Moreover, future research should examine the effects of cognitive behavioral therapy for insomnia on circadian factors.

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J. Ell, F. Benz, N. Walter, L. Steinmetz, H. Brückner, D. Lehr, D. Riemann und K. Spiegelhalder geben an, dass kein Interessenkonflikt besteht.

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Ell, J., Benz, F., Walter, N. et al. Chronobiologische Aspekte der Insomnie. Somnologie 25, 110–118 (2021). https://doi.org/10.1007/s11818-021-00295-8

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