Abstract
The control synthesis of nanoparticles was the implementation process of material ideal design. Nano-hydroxyapatite (HAP) was prepared by a hydrothermal method with calcium nitrate and diammonium hydrogen phosphate as raw material, to study its characteristics for morphology modification by arginine-functionalization and doping with rare earth such as Tb3+. The crystallization, grain size and dispersibility of the sample HAP were analyzed and discussed. The results show that the surface Zeta potential of arginine-functionalized HAP is changed, and the growth rate of HAP is inhibited to a certain extent during the synthesis. The structure of HAP/Arg is not affected during the synthesis by a small amount of rare earth ions doped such as Tb3+, and has a single phase of HAP with good dispersibility. The synthesized HAP is also of nano-sized level. Nano-hydroxyapatite argininefunctionalized and doped with rare earth such as Tb3+, is suitable for the application of gene delivery as a gene carrier.
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Foundation item: Project(2013SK2024) supported by the Key Projects in Social Development Pillar Program of Hunan Province, China; Project(20130162120094) supported by Specialized Research Fund for the Doctoral Program of Higher Education (SRFDP), Ministry of Education, China; Project supported by State Key Laboratory of Powder Metallurgy, Central South University, China
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Zhao, Yz., Yang, M., Zhang, Hb. et al. Characterization of terbium-doped nano-hydroxyapatite and surface modification. J. Cent. South Univ. 23, 1548–1555 (2016). https://doi.org/10.1007/s11771-016-3207-9
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DOI: https://doi.org/10.1007/s11771-016-3207-9