Skip to main content
Log in

Characterization of terbium-doped nano-hydroxyapatite and surface modification

  • Materials, Metallurgy, Chemical and Environmental Engineering
  • Published:
Journal of Central South University Aims and scope Submit manuscript

Abstract

The control synthesis of nanoparticles was the implementation process of material ideal design. Nano-hydroxyapatite (HAP) was prepared by a hydrothermal method with calcium nitrate and diammonium hydrogen phosphate as raw material, to study its characteristics for morphology modification by arginine-functionalization and doping with rare earth such as Tb3+. The crystallization, grain size and dispersibility of the sample HAP were analyzed and discussed. The results show that the surface Zeta potential of arginine-functionalized HAP is changed, and the growth rate of HAP is inhibited to a certain extent during the synthesis. The structure of HAP/Arg is not affected during the synthesis by a small amount of rare earth ions doped such as Tb3+, and has a single phase of HAP with good dispersibility. The synthesized HAP is also of nano-sized level. Nano-hydroxyapatite argininefunctionalized and doped with rare earth such as Tb3+, is suitable for the application of gene delivery as a gene carrier.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. BROWN W E, CHOW L C. A new calcium phosphate, watersetting cemen [J]. American Ceramic Society, 1987, 4: 352–379.

    Google Scholar 

  2. YANG Chun, GUO Ying-kui, ZHANG Mi-lin. Thermal decomposition and mechanical properties of hydroxyapatite ceramic [J]. Transactions of Nonferrous Metals Society of China, 2010, 20(2): 254–258.

    Article  Google Scholar 

  3. SUEN R B, LIN S C, HSU W H. Hydroxyapatite-based immobilized metal affinity adsorbents for protein purification [J]. Journal of Chromatography A, 2004, 1048(1): 31–39.

    Article  Google Scholar 

  4. LEGEROS R Z. Properties of osteoconductive biomaterials: Calciumphosphates [J]. Clinical Orthopaedics and Related Research, 2002, 395: 81–98.

    Article  Google Scholar 

  5. AOKI H, KUTSUNO T. An in vivo study on the reaction of hydroxyapatite-sol injected into blood [J]. Journal of Materials Science: Materials in Medicine, 2000, 11: 67–72.

    Google Scholar 

  6. LIU Zhi-su, TANG Sheng-li, AI Zhong-li. Effects of hydroxyapatite nanoparticles on proliferation and apoptosis of human hepatoma BEL-7402 cells [J]. World Journal of Gastroenterology, 2003, 9(9): 1968–1971.

    Article  Google Scholar 

  7. ZANG Li-ge. Comparison of the vector capacity of different modified hydroxyapatite nanoparticles as gene vectors [D]. Changsha: Central South University, 2008. (in Chinese)

    Google Scholar 

  8. DO T N, LEE W H, LOO C Y, ZAVGORODNIY A V, ROHANIZADEH R. Hydroxyapatite nanoparticles as vectors for gene delivery [J]. Therapeutic Delivery, 2012, 3(5): 623–632.

    Article  Google Scholar 

  9. MAO Yue-feng. Study on the transfection efficiency of chitosan modified nano hydroxyapatite as gene transfer carrier [D]. Changsha: Central South University, 2009. (in Chinese)

    Google Scholar 

  10. ZUO Gui-fu, WAN Yi-zao, ZHANG Yu. Preparation and characterization of a novel laminated magnetic hydroxyapatite for application on gene delivery [J]. Materials Letters, 2012, 68: 225–227.

    Article  Google Scholar 

  11. LI Yan, YANG Jun, LIU Gui-ying, ZHANG Xin. Research situation and development trend of gene therapy for drug delivery system [J]. Progress in Biochemistry and Biophysics, 2013, 44(10): 998–1007. (in Chinese)

    Google Scholar 

  12. KIKUCHI M. Hydroxyapatite/collagen bone-like nanocomposite [J]. Biological and Pharmaceutical Bulletin, 2013, 36(11): 1666–1669.

    Article  MathSciNet  Google Scholar 

  13. LI Shu-li. Preparation and study of hydroxyapatite drug delivery microspheres [D]. Tianjin: Tianjin University, 2008. (in Chinese)

    Google Scholar 

  14. ZHOU Hai-long. Study on the adsorption mechanism of BMP-7 onto HAP surfaces [D]. Zhejiang: Zhejiang University, 2007. (in Chinese)

    Google Scholar 

  15. PAGANO G, GUIDA M, TOMMASI F, ORAL R. Health effects and toxicity mechanisms of rare earth elements-Knowledge gaps and research prospects [J]. Ecotoxicology and Environmental Safety, 2015, 115: 40–48.

    Article  Google Scholar 

  16. FERNANDEZ-OSORIO A, RIVERA C E, VAZQUEZ-OLMOS A, CHAVEZ J. Luminescent ceramic nano-pigments based on terbium-doped zinc aluminate: Synthesis, properties and performance [J]. Dyes and Pigments, 2015, 119: 22–29.

    Article  Google Scholar 

  17. RAMBABU U, AMALNERKAR D P, KALE B B, BUDDHUDU S. Optical properties of LnPO4:Tb3+(Ln=Y, La and Gd) powder phosphors [J]. Materials Chemistry and Physics, 2001, 70(1): 1–6.

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Yan-zhong Zhao  (赵颜忠).

Additional information

Foundation item: Project(2013SK2024) supported by the Key Projects in Social Development Pillar Program of Hunan Province, China; Project(20130162120094) supported by Specialized Research Fund for the Doctoral Program of Higher Education (SRFDP), Ministry of Education, China; Project supported by State Key Laboratory of Powder Metallurgy, Central South University, China

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Zhao, Yz., Yang, M., Zhang, Hb. et al. Characterization of terbium-doped nano-hydroxyapatite and surface modification. J. Cent. South Univ. 23, 1548–1555 (2016). https://doi.org/10.1007/s11771-016-3207-9

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s11771-016-3207-9

Keywords

Navigation