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The dual relationship between polypharmacy and frailty in nursing home residents: polypharmacy as a cause or a consequence?

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References

  1. Jokanovic N, Tan ECK, Dooley MJ et al (2015) Prevalence ad factors associated with polypharmacy in long-term care facilities: a systematic review. J Am Med Dir Assoc 16:535.e1-535.e12. https://doi.org/10.1016/j.jamda.2015.03.003

    Article  Google Scholar 

  2. Saum K-U, Schöttker B, Meid AD et al (2017) Is polypharmacy associated with frailty in older people? results from the ESTHER Cohort Study. J Am Geriatr Soc 65:e27–e32. https://doi.org/10.1111/jgs.14718

    Article  PubMed  Google Scholar 

  3. Gnjidic D, Hilmer SN, Blyth FM et al (2012) Polypharmacy cutoff and outcomes: five or more medicines were used to identify community-dwelling older men at risk of different adverse outcomes. J Clin Epidemiol 65:989–995. https://doi.org/10.1016/j.jclinepi.2012.02.018

    Article  PubMed  Google Scholar 

  4. Clegg A, Young J, Iliffe S et al (2013) Frailty in elderly people. Lancet 381:752–762

    Article  Google Scholar 

  5. Mitnitski AB, Mogilner AJ, Rockwood K (2001) Accumulation of deficits as a proxy measure of aging. ScientificWorldJournal 1:323–336. https://doi.org/10.1100/tsw.2001.58

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  6. Calcaterra L, Proietti M, Saporiti E, Nunziata V, Rolland Y, Vellas B, Cesari M (2021) Predictors of drug prescription in nursing home residents: results from the INCUR study. Intern Emerg Med. https://doi.org/10.1007/s11739-021-02841-6 (PMID: 34546497)

    Article  PubMed  Google Scholar 

  7. Demougeot L, Rolland Y, Gérard S et al (2013) Incidence and economical effects of pneumonia in the older population living in French nursing homes: design and methods of the INCUR study. BMC Public Health 13:861. https://doi.org/10.1186/1471-2458-13-861

    Article  PubMed  PubMed Central  Google Scholar 

  8. Onder G, Liperoti R, Fialova D et al (2012) Polypharmacy in nursing home in Europe: results from the SHELTER Study. J Gerontol Ser A Biol Sci Med Sci 67A:698–704. https://doi.org/10.1093/gerona/glr233

    Article  Google Scholar 

  9. Tjia J, Velten SJ, Parsons C et al (2013) Studies to reduce unnecessary medication use in frail older adults: a systematic review. Drugs Aging 30:285–307

    Article  Google Scholar 

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Author notes

  1. Federica Giardino and Gelsomina Landi are equally contributed.

Authors and Affiliations

  1. Department of Translational Medical Sciences, Interdisciplinary Research Centre in Biomedical Materials (C.R.I.B.), University Federico II of Naples, Via Pansini 5, 80131, Naples, Italy

    Federica Giardino, Gelsomina Landi, Michele Arcopinto, Antonio Cittadini & Alberto Maria Marra

  2. Centre for Pulmonary Hypertension, Thoraxklinik at Heidelberg University Hospital, Heidelberg, Germany

    Alberto Maria Marra

  3. Translational Lung Research Center Heidelberg (TLRC), Member of the German Center for Lung Research (DZL), Heidelberg, Germany

    Alberto Maria Marra

Authors
  1. Federica Giardino
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  2. Gelsomina Landi
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  3. Michele Arcopinto
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  4. Antonio Cittadini
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  5. Alberto Maria Marra
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Correspondence to Alberto Maria Marra.

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Giardino, F., Landi, G., Arcopinto, M. et al. The dual relationship between polypharmacy and frailty in nursing home residents: polypharmacy as a cause or a consequence?. Intern Emerg Med 17, 11–12 (2022). https://doi.org/10.1007/s11739-021-02885-8

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  • DOI: https://doi.org/10.1007/s11739-021-02885-8

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