Abstract
Comorbidities are common in elderly patients with hip fracture and are associated with an increased mortality after surgery. Internal medicine/geriatric leaded multidisciplinary hip fracture teams may play a pivotal role in the clinical management of complex patients. Treatment strategy is particular relevant in patients with severe aortic stenosis that represent more than 5% of patients with hip fracture. These patients have a high in-hospital mortality and poor 1-year survival (less than 50%). Transcatheter aortic valve replacement (TAVR) may be an option in selected patients; however, the choice to treat and, in the case, the timing of valve replacement in relation to hip surgery is highly dependent on clinical conditions before trauma. In this paper, three different scenario of TAVR timing after hip fracture are reported.
References
Adunsky A, Kaplan A, Arad M, Mizrahi EH, Gottlieb S (2008) Aortic stenosis in elderly hip fractured patients. Arch Gerontol Geriatr 46(3):401–408. https://doi.org/10.1016/j.archger.2007.05.013 (Epub 2007 Jul 12. PMID: 21247310)
Keswani A, Lovy A, Khalid M, Blaufarb I, Moucha C et al (2016) The effect of aortic stenosis on elderly hip fracture outcomes: a case control study. Injury 47(2):413–418. https://doi.org/10.1016/j.injury.2015.10.015 (PMID: 26556487)
McBrien ME, Heyburn G, Stevenson M, McDonald S, Johnston NJ, Elliott JR, Beringer TR (2009) Previously undiagnosed aortic stenosis revealed by auscultation in the hip fracture population–echocardiographic findings, management and outcome. Anaesthesia 64(8):863–870. https://doi.org/10.1111/j.1365-2044.2009.05960 (PMID: 19604190)
Rostagno C, Ranalli C, Polidori G, Cartei A, Boccaccini A, Peris A (2019) Outcome in elderly patients with aortic stenosis undergoing hip fracture surgery. Results may suggest a different postoperative strategy? Trauma Surg Acute Care Open 4(1):e000218. https://doi.org/10.1136/tsaco-2018-000218 (PMID: 3072917)
Fleisher LA, Fleischmann KE, Barnason AAD, SA, Beckman JA, et al (2014) 2014 ACC/AHA guidelines on perioperative cardiovascular evaluation and management of patients undergoing non cardiac surgery: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines. J Am Coll Cardiol 64:2372–2405. https://doi.org/10.1016/j.jacc.2014.07.944 (PMID: 2509154)
Kristensen SD, Knuuti J, Saraste A, Anker S, Bøtker HE, De Hert S et al (2014) The Joint Task Force on non-cardiac surgery: cardiovascular assessment and management of the European Society of Cardiology (ESC) and the European Society of Anaesthesiology (ESA) 2014 ESC/ESA Guidelines on non-cardiac surgery: cardiovascular assessment and management. Eur Heart J 35:2383–2424. https://doi.org/10.1097/EJA.0000000000000150 (PMID: 25127426)
Baumgartner H, Falk V, Bax JJ, De Bonis M, Hamm C, Holm PJ, Iung B, Lancellotti P, Lansac E, Rodriguez Muñoz D, Rosenhek R, Sjögren J, Tornos Mas P, Vahanian A, Walther T, Wendler O, Windecker S, Zamorano JL, ESC Scientific Document Group (2017) 2017 ESC/EACTS Guidelines for the management of valvular heart disease. Eur Heart J. 38(36):2739–2791. https://doi.org/10.1093/eurheartj/ehx391 (PMID: 28886619)
Popma JJ, Adams DH, Reardon MJ, Yakubov SJ, Kleiman NS et al (2014) Transcatheter aortic valve replacement using a self-expanding bioprosthesis in patients with severe aortic stenosis at extreme risk for surgery. J Am Coll Cardiol 63:1972–1981. https://doi.org/10.1016/j.jacc.2014.02.556 (PMID: 24657695)
Thongprayoon C, Cheungpasitporn W, Kashani K (2017) The impact of frailty on mortality after transcatheter aortic valve replacement. Ann Transl Med. 5(6):144. https://doi.org/10.21037/atm.2017.01.35 (PMID: 28462224)
Finn M, Green P (2014) Transcatheter aortic valve implantation in the elderly: who to refer? Prog Cardiovasc Dis 57:215–225. https://doi.org/10.1016/j.pcad.2014.08.003 (PMID: 2521662)
Ahmed T, Safdar A (2020) The management dilemma: concomitant acute hip fracture and severe asymptomatic aortic stenosis. Cureus. 12(4):e7527. https://doi.org/10.7759/cureus.7527 (PMID: 32377475)
Misawa Y, Sato S, Aizawa K et al (2019) Hip fracture repair with concomitant transcatheter aortic valve implantation. Report of a Case. Kyobu Geka 72(3):224–227 (PMID: 30923300)
Kiani S, Stebbins A, Thourani VH, Forcillo J, Vemulapalli S, Kosinski AS, Babaliaros V, Cohen D, Kodali SK, Kirtane AJ, Hermiller JB Jr, Stewart J, Lowenstern A, Mack MJ, Guyton RA, Devireddy C, STS/ACC TVT Registry (2020) The effect and relationship of frailty indices on survival after transcatheter aortic valve replacement. JACC Cardiovasc Interv. 13(2):219–231. https://doi.org/10.1016/j.jcin.2019.08.015 (PMID: 31973795)
Rockwood K, Song X, MacKnight C, Bergman H, Hogan DB, McDowell I, Mitnitski A (2005) A global clinical measure of fitness and frailty in elderly people. CMAJ 173:489–495
Rostagno C, Cartei A, Buzzi R, Santoro G (2015) Aortic ballon valvuloplasty is still a valuable option for high risk patients with severe aortic stenosis before surgery for hip fracture. Int J Cardiovasc Res 4:5. https://doi.org/10.4172/2324-8602.100022
Ferré F, Viarnes M, Martin C, Bosch L, Bouisset F, Lhermusier T, Reina N, Lairez O, Minville V (2020) Is preoperative balloon aortic valvuloplasty of interest for severe aortic stenosis in hip fracture surgery? Injury. https://doi.org/10.1016/j.injury.2020.09.048 (Epub ahead of print. PMID: 32998825)
Feely MA, Mabry TA, Lohse CM, Sems CA, Mauck FA (2013) Safety of clopidogrel in hip fracture surgery. Mayo Clin Proc. https://doi.org/10.1016/j.mayocp2012.11.007
Rostagno C, Peris A, Polidori GL, Ranalli C, Cartei A, Civinini R, Boccaccini A, Prisco D, Innocenti M, Di Mario C (2019) Perioperative myocardial infarction in elderly patients with hip fracture. Is there a role for early coronary angiography? Int J Cardiol 284:1–5. https://doi.org/10.1016/j.ijcard.2018.10.095 (Epub 2018 Oct 29 PMID: 30420143)
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Rostagno, C., Falchetti, G., Rostagno, A.C. et al. TAVR in patients with hip fracture and severe aortic stenosis: how and when?. Intern Emerg Med 16, 1419–1422 (2021). https://doi.org/10.1007/s11739-021-02752-6
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DOI: https://doi.org/10.1007/s11739-021-02752-6