Skip to main content

Advertisement

Log in

TAVR in patients with hip fracture and severe aortic stenosis: how and when?

  • IM-Point of view
  • Published:
Internal and Emergency Medicine Aims and scope Submit manuscript

Abstract

Comorbidities are common in elderly patients with hip fracture and are associated with an increased mortality after surgery. Internal medicine/geriatric leaded multidisciplinary hip fracture teams may play a pivotal role in the clinical management of complex patients. Treatment strategy is particular relevant in patients with severe aortic stenosis that represent more than 5% of patients with hip fracture. These patients have a high in-hospital mortality and poor 1-year survival (less than 50%). Transcatheter aortic valve replacement (TAVR) may be an option in selected patients; however, the choice to treat and, in the case, the timing of valve replacement in relation to hip surgery is highly dependent on clinical conditions before trauma. In this paper, three different scenario of TAVR timing after hip fracture are reported.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Fig. 1

References

  1. Adunsky A, Kaplan A, Arad M, Mizrahi EH, Gottlieb S (2008) Aortic stenosis in elderly hip fractured patients. Arch Gerontol Geriatr 46(3):401–408. https://doi.org/10.1016/j.archger.2007.05.013 (Epub 2007 Jul 12. PMID: 21247310)

    Article  PubMed  Google Scholar 

  2. Keswani A, Lovy A, Khalid M, Blaufarb I, Moucha C et al (2016) The effect of aortic stenosis on elderly hip fracture outcomes: a case control study. Injury 47(2):413–418. https://doi.org/10.1016/j.injury.2015.10.015 (PMID: 26556487)

    Article  PubMed  Google Scholar 

  3. McBrien ME, Heyburn G, Stevenson M, McDonald S, Johnston NJ, Elliott JR, Beringer TR (2009) Previously undiagnosed aortic stenosis revealed by auscultation in the hip fracture population–echocardiographic findings, management and outcome. Anaesthesia 64(8):863–870. https://doi.org/10.1111/j.1365-2044.2009.05960 (PMID: 19604190)

    Article  CAS  PubMed  Google Scholar 

  4. Rostagno C, Ranalli C, Polidori G, Cartei A, Boccaccini A, Peris A (2019) Outcome in elderly patients with aortic stenosis undergoing hip fracture surgery. Results may suggest a different postoperative strategy? Trauma Surg Acute Care Open 4(1):e000218. https://doi.org/10.1136/tsaco-2018-000218 (PMID: 3072917)

    Article  PubMed  PubMed Central  Google Scholar 

  5. Fleisher LA, Fleischmann KE, Barnason AAD, SA, Beckman JA, et al (2014) 2014 ACC/AHA guidelines on perioperative cardiovascular evaluation and management of patients undergoing non cardiac surgery: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines. J Am Coll Cardiol 64:2372–2405. https://doi.org/10.1016/j.jacc.2014.07.944 (PMID: 2509154)

    Article  Google Scholar 

  6. Kristensen SD, Knuuti J, Saraste A, Anker S, Bøtker HE, De Hert S et al (2014) The Joint Task Force on non-cardiac surgery: cardiovascular assessment and management of the European Society of Cardiology (ESC) and the European Society of Anaesthesiology (ESA) 2014 ESC/ESA Guidelines on non-cardiac surgery: cardiovascular assessment and management. Eur Heart J 35:2383–2424. https://doi.org/10.1097/EJA.0000000000000150 (PMID: 25127426)

    Article  PubMed  Google Scholar 

  7. Baumgartner H, Falk V, Bax JJ, De Bonis M, Hamm C, Holm PJ, Iung B, Lancellotti P, Lansac E, Rodriguez Muñoz D, Rosenhek R, Sjögren J, Tornos Mas P, Vahanian A, Walther T, Wendler O, Windecker S, Zamorano JL, ESC Scientific Document Group (2017) 2017 ESC/EACTS Guidelines for the management of valvular heart disease. Eur Heart J. 38(36):2739–2791. https://doi.org/10.1093/eurheartj/ehx391 (PMID: 28886619)

    Article  PubMed  Google Scholar 

  8. Popma JJ, Adams DH, Reardon MJ, Yakubov SJ, Kleiman NS et al (2014) Transcatheter aortic valve replacement using a self-expanding bioprosthesis in patients with severe aortic stenosis at extreme risk for surgery. J Am Coll Cardiol 63:1972–1981. https://doi.org/10.1016/j.jacc.2014.02.556 (PMID: 24657695)

    Article  PubMed  Google Scholar 

  9. Thongprayoon C, Cheungpasitporn W, Kashani K (2017) The impact of frailty on mortality after transcatheter aortic valve replacement. Ann Transl Med. 5(6):144. https://doi.org/10.21037/atm.2017.01.35 (PMID: 28462224)

    Article  PubMed  PubMed Central  Google Scholar 

  10. Finn M, Green P (2014) Transcatheter aortic valve implantation in the elderly: who to refer? Prog Cardiovasc Dis 57:215–225. https://doi.org/10.1016/j.pcad.2014.08.003 (PMID: 2521662)

    Article  PubMed  PubMed Central  Google Scholar 

  11. Ahmed T, Safdar A (2020) The management dilemma: concomitant acute hip fracture and severe asymptomatic aortic stenosis. Cureus. 12(4):e7527. https://doi.org/10.7759/cureus.7527 (PMID: 32377475)

    Article  PubMed  PubMed Central  Google Scholar 

  12. Misawa Y, Sato S, Aizawa K et al (2019) Hip fracture repair with concomitant transcatheter aortic valve implantation. Report of a Case. Kyobu Geka 72(3):224–227 (PMID: 30923300)

    PubMed  Google Scholar 

  13. Kiani S, Stebbins A, Thourani VH, Forcillo J, Vemulapalli S, Kosinski AS, Babaliaros V, Cohen D, Kodali SK, Kirtane AJ, Hermiller JB Jr, Stewart J, Lowenstern A, Mack MJ, Guyton RA, Devireddy C, STS/ACC TVT Registry (2020) The effect and relationship of frailty indices on survival after transcatheter aortic valve replacement. JACC Cardiovasc Interv. 13(2):219–231. https://doi.org/10.1016/j.jcin.2019.08.015 (PMID: 31973795)

    Article  PubMed  Google Scholar 

  14. Rockwood K, Song X, MacKnight C, Bergman H, Hogan DB, McDowell I, Mitnitski A (2005) A global clinical measure of fitness and frailty in elderly people. CMAJ 173:489–495

    Article  Google Scholar 

  15. Rostagno C, Cartei A, Buzzi R, Santoro G (2015) Aortic ballon valvuloplasty is still a valuable option for high risk patients with severe aortic stenosis before surgery for hip fracture. Int J Cardiovasc Res 4:5. https://doi.org/10.4172/2324-8602.100022

    Article  Google Scholar 

  16. Ferré F, Viarnes M, Martin C, Bosch L, Bouisset F, Lhermusier T, Reina N, Lairez O, Minville V (2020) Is preoperative balloon aortic valvuloplasty of interest for severe aortic stenosis in hip fracture surgery? Injury. https://doi.org/10.1016/j.injury.2020.09.048 (Epub ahead of print. PMID: 32998825)

    Article  PubMed  Google Scholar 

  17. Feely MA, Mabry TA, Lohse CM, Sems CA, Mauck FA (2013) Safety of clopidogrel in hip fracture surgery. Mayo Clin Proc. https://doi.org/10.1016/j.mayocp2012.11.007

    Article  PubMed  Google Scholar 

  18. Rostagno C, Peris A, Polidori GL, Ranalli C, Cartei A, Civinini R, Boccaccini A, Prisco D, Innocenti M, Di Mario C (2019) Perioperative myocardial infarction in elderly patients with hip fracture. Is there a role for early coronary angiography? Int J Cardiol 284:1–5. https://doi.org/10.1016/j.ijcard.2018.10.095 (Epub 2018 Oct 29 PMID: 30420143)

    Article  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Carlo Rostagno.

Ethics declarations

Conflict of interest

The authors declare that they have no conflict of interest.

Statement of human and animal rights

All procedure performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards.

Informed consent

Informed consent was obtained at hospital admission.

Additional information

Publisher's Note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

The study is part of a project of Italian Health Ministry and Regione Toscana- RF-2010-2316600.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Rostagno, C., Falchetti, G., Rostagno, A.C. et al. TAVR in patients with hip fracture and severe aortic stenosis: how and when?. Intern Emerg Med 16, 1419–1422 (2021). https://doi.org/10.1007/s11739-021-02752-6

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s11739-021-02752-6

Keywords

Navigation