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Preparation of paclitaxel-loaded microspheres with magnetic nanoparticles

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Abstract

The objective of this paper was to prepare paclitaxel-loaded microspheres, a kind of target-orientation anticancer drug. The paclitaxel-loaded microspheres were prepared with magnetic Fe3O4 nanoparticles and taxol. The morphology was characterized by scanning electron microscopy (SEM), and the average size and the size distribution were determined by a laser-size distributing instrument. High performance liquid chromatography (HPLC) was used to measure the paxlitaxel content. Experimental results indicated that the effective drug loading and the entrapment ratio of paclitaxel-loaded microspheres were 1.83% and 92.62%, respectively.

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Authors and Affiliations

  1. College of Materials Science and Technology, Nanjing University of Technology, Nanjing, 210009, China

    Cui Sheng, Shen Xiaodong & Lin Benlan

  2. The First Affiliated Hospital of Nanjing Medical University, Nanjing, 210029, China

    Shi Ruihua & Chen Ping

Authors
  1. Cui Sheng
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  2. Shen Xiaodong
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  3. Shi Ruihua
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  4. Lin Benlan
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  5. Chen Ping
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Correspondence to Cui Sheng.

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Cui, S., Shen, X., Shi, R. et al. Preparation of paclitaxel-loaded microspheres with magnetic nanoparticles. Front. Mater. Sci. China 1, 383–387 (2007). https://doi.org/10.1007/s11706-007-0070-5

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  • DOI: https://doi.org/10.1007/s11706-007-0070-5

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