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Synthesis and characterisation of graphene oxide decorated gold nano particles and their application towards antibacterial activity

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Abstract

Graphene oxide coated gold nano particles are emerging materials in many applications because of their distinctive properties. In this work, we have prepared a very simple and eco-friendly method for the synthesis of graphene oxide (GO) and graphene oxide decorated gold nano particles (GO–Au NPs). The spectral, and morphological characteristics were analysed using various instrumental analysis. Also, the investigation deals with the screening of antibacterial activity of graphene oxide, gold nano particles and the graphene oxide decorated Gold NPs against Gram-positive bacterial strain Staphylococcus aureus and Gram-negative bacterial strain Eschrichia coli by disc diffusion test and minimum inhibitory concentration. It was observed that the hybrid graphene oxide decorated Gold NPs showed better antibacterial activity than the other two tested components.

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References

  • Akhavan O, Ghaderi E (2010) Toxicity of graphene and graphene oxide nanowalls against bacteria. ACS Nano 4:5731–5736

    Article  CAS  PubMed  Google Scholar 

  • Bindhu MR, Umadevi M (2014) Antibacterial activities of green synthesized gold nanoparticles. Mater Lett 120:122–125

    Article  CAS  Google Scholar 

  • Britto Hurtado R, Cortez-Valadez M, Aragon-Guajardo JR, Cruz-Rivera JJ, Martınez-Suarez F, Flores-Acosta M (2020) One-step synthesis of reduced graphene oxide/gold nanoparticles under ambient conditions. Arab J Chem 13(1):1633–1640

  • Brukh R, Mitra S (2007) Kinetics of carbon nanotube oxidation. J Mater Chem 17:619–623

    Article  CAS  Google Scholar 

  • Chook SW, Chia CH, Zakaria S (2012) Antibacterial performance of Ag nanoparticles and Ag GO nanocomposites prepared via rapid microwave-assisted synthesis method. Nanoscale Res Lett 7:541

    Article  PubMed  PubMed Central  Google Scholar 

  • Compton OC, Jain B, Dikin DA (2011) Chemically active reduced graphene oxide with tunable C/O ratios. ACS Nano 5:4380–4391

    Article  CAS  PubMed  Google Scholar 

  • De Jong WH (2008) Drug delivery and nanoparticles: applications and hazards. Int J Nanomed 3(2):133–139

    Article  Google Scholar 

  • Díez-Pascual AM (2020) Antibacterial action of nanoparticle loaded nanocomposites based on graphene and its derivatives: a mini-review. Int J Mol Sci 21(10):3563

    Article  PubMed Central  Google Scholar 

  • Grace E, Annamalai A (2016) Cytotoxicity and antibacterial characteristics of graphene-oxide nanosheets toward human pathogens. J Nanosci Nanotechnol 16:2447–2452

    Article  CAS  PubMed  Google Scholar 

  • Grandhi TSP, Rege K (2014) Design synthesis and functionalization of nanomaterials for therapeutic drug delivery. In: Nanomaterial. Advances in experimental medicine and biology. Springer, Dordrecht, pp 157–182

  • Gurunathan S, Han JW, Kim ES, Park JH, Kim JH (2015) Reduction of graphene oxide by resveratrol: a novel and simplebiological method for the synthesis of an effective anti-cancernanotherapeutic molecule. Int J Nanomed 10:2951–2969

    Article  CAS  Google Scholar 

  • Hummers WS Jr, Offeman RE (1958) Preparation of graphitic oxide. J Am ChemSoc 80(6):1339–1339

    Article  CAS  Google Scholar 

  • Hussain N, Gogoi A, Sarma RK, Sharma P, Barras A, Boukherroub R, Saikia R, Sengupta P, Das MR (2014) Reduced graphene oxide nanosheets decorated with Au nanoparticles as an effective bactericide: Investigation of biocompatibility and leakage of sugars and proteins. ChemPlusChem 79:1774–1784

    CAS  Google Scholar 

  • Iliut M, Leordean C, Canpean V, Teodorescu C-M, Astilean S (2013) A new green, ascorbic acid-assisted method for versatile synthesis of Au–graphene hybrids as efficient surface-enhanced raman scattering platforms. J Mater Chem C 1:4094–4104

    Article  CAS  Google Scholar 

  • Jariwala D, Sangwan VK, Lauhon LJ, Marks TJ, Hersam MC (2013) Carbon nanomaterials for electronics, optoelectronics, photovoltaics, and sensing. Chem Soc Rev 42:2824–2860

    Article  CAS  PubMed  Google Scholar 

  • Konwar A, Kalita S, Kotoky J, Chowdhury D (2013) Chitosan–iron oxide coated graphene oxide nanocomposite hydrogel: a robust and soft antimicrobial biofilm. ACS Appl Mater Interface 8:20625–20634

    Article  Google Scholar 

  • Liu S, Zeng TH, Hofmann M, Burcombe E, Wei J, Jiang R, Kong J, Chen Y (2011) Antibacterial activity of graphite, graphite oxide, graphene oxide, and reduced graphene oxide: membrane and oxidative stress. ACS Nano 5:6971–6980

    Article  CAS  PubMed  Google Scholar 

  • Nancy P, Nair AK, Antoine R, Thomas S, Kalarikkal N (2019) In situ decoration of gold nanoparticles on graphene oxide via nanosecond laser ablation for remarkable chemical sensing and catalysis. Nanomaterials 9(1201):1–14

    Google Scholar 

  • Nester EW, Anderson DG, Roberts E, Pearshall NN, Nester MT (2003) Microbiology: a Human Perspect. 14:518–521

  • Paszkiewicz M, Gołąbiewska A (2016) The antibacterial and antifungal textile properties functionalized by bimetallic nanoparticles of Ag/Cu with different structures. J Nanomater

  • Perreault F, Faria AF, Nejati S, Elimelech M (2015) Antimicrobial properties of graphene oxide nanosheets: why size matters. ACS Nano 9:226–7236

    Article  Google Scholar 

  • Porter E, Gass M, Muller K, Skepper JN, Midgley PA, Welland M (2007) Direct imaging of single-walled carbon nanotubes in cells. Nat Nanotechnol 2:713–717

    Article  CAS  PubMed  Google Scholar 

  • Saikia I, Sonowal S, Pal M, Baruah PK, Das MR, Tamuly C (2016) Biosynthesis of gold decorated reduced graphene oxide and its biological activities. Mater Lett 178:239–242

    Article  CAS  Google Scholar 

  • Saikia I, Hazarika M, Pal M, Das MR, Borah JC, Tamuly C (2018) Green synthesis of Au-Ag-In-rGO nanocomposites and its α-glucosidase inhibition and cytotoxicity effects. Mater Lett 211:48–50

    Article  CAS  Google Scholar 

  • Shao Y, Wang J, Engelhard M, Wang C, Lin Y (2010) Facile and controllable electrochemical reduction of graphene oxide and its applications. J Mater Chem 20(4):743–774

    Article  CAS  Google Scholar 

  • Slavin YN, Asnis J, Häfeli UO, Bach H (2017) Metal nanoparticles: understanding the mechanisms behind antibacterial activity. J Nanobiotechnol 15:1–20

    Article  Google Scholar 

  • Smitha SL, Gopchandran KG (2013) Surface enhanced Raman scattering, antibacterial and antifungal active triangular gold nanoparticles. Spectrochim Actaa Mol Biomol Spectrosc 102:114–119

    Article  CAS  Google Scholar 

  • Stensberg MC, Wei Q, McLamore ES, Porterfield DM (2011) Toxicological studies on silver nanoparticles: challenges and opportunities in assessment, monitoring and imaging. Nanomedicine 6:879–898

    Article  CAS  PubMed  Google Scholar 

  • Tang J, Chen Q, Xu L, Zhang S, Feng L, Cheng L, Xu H, Liu Z, Peng R (2013) Graphene oxide–silver nanocomposite as a highly effective antibacterial agent with species-specific mechanisms. ACS Appl Mater Interfaces 5:3867–3874

    Article  CAS  PubMed  Google Scholar 

  • Tîlmaciu CM, Morris MC (2015) Carbon nanotube biosensors. Front Chem 3:1–21

    Article  Google Scholar 

  • Wang Y, Li ZH, Hu DH, Lin CT, Li JH, Lin YH (2010) Aptamer/graphene oxide nanocomplex for in situ molecular probing in living cells. J Am Chem Soc 132:9274–9276

    Article  CAS  PubMed  Google Scholar 

  • Xiong Z, Zhang LL, Ma J, Zhao X (2010) Photocatalytic degradation of dyes over graphene–gold nanocomposites under visible light irradiation. ChemCommun 46(33):6099–6101

    CAS  Google Scholar 

  • Yu S, Yin Y, Liu J (2013) Silver nanoparticles in the environment. Environ Sci Process Impacts 15:78–92

    Article  PubMed  Google Scholar 

  • Yuan P, Ding X, Yang YY, Xu QH (2018) Metal nanoparticles for diagnosis and therapy of bacterial infection. Adv Healthc Mater 7:1–17

    Article  Google Scholar 

  • Zhou Y, Kong Y, Kundu S, Cirillo JD, Liang H (2012) Antibacterial activities of gold and silver nanoparticles against Escherichia coli and bacillus Calmette-Guérin. J Nanobiotechnol 10(1):19

    Article  CAS  Google Scholar 

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Correspondence to V. Jaisankar.

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Shalini, A., Priya, K., Kothai, S. et al. Synthesis and characterisation of graphene oxide decorated gold nano particles and their application towards antibacterial activity. Chem. Pap. 76, 6861–6867 (2022). https://doi.org/10.1007/s11696-022-02375-x

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