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Development of fully bio-based pectin/curcumin@bio-MOF-11 for colon specific drug delivery

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Abstract

The current study is carried out on curcumin delivery, which is recognized as an anticancer drug, to cancerous cells through a bio-metal–organic framework (bioMOF). After being immersed within the drug solution, the process of curcumin encapsulation was conducted in the porous bio-MOF-11. Furthermore, both protecting and carrying curcumin encapsulated bio-MOF-11 nanohybrid (curcumin@bio-MOF-11) within the gastrointestinal tract (GIT) were carried out using pH-sensitive pectin biopolymer. There were two different approaches applied to identify the pectin-coated curcumin@bio-MOF-11bio-nanocomposite hydrogel bead (pectin/curcumin@bio-MOF-11). Using the simulated GIT conditions, in-vitro drug release tests were conducted to illustrate the pectin/curcumin@bio-MOF-11effectiveness that was applied to the process of curcumin controlled delivery as a new carrier. Consequently, results showed that there was a constant release associated with pectin/curcumin@bio-MOF-11 under GIT conditions. Moreover, considerable toxicity of pectin/curcumin@bio-MOF-11 against human colon carcinoma cells was confirmed through the MTT test. Results implied that provided bio-nanocomposite hydrogel beads could act as appropriate drug delivery systems of curcumin colonic drug release.

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Acknowledgements

We gratefully acknowledge financial support from the National Natural Science Foundation of China (Grant No.: 22050410269).

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  1. State Key Laboratory of Fire Science, University of Science and Technology of China, 96 Jinzhai Road, Hefei, 230026, Anhui, People’s Republic of China

    Hafezeh Nabipour & Yuan Hu

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  1. Hafezeh Nabipour
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  2. Yuan Hu
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HN was in charge of the experimental implementation, data analysis, and writing of original draft. YH revised the manuscript.

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Correspondence to Hafezeh Nabipour.

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Nabipour, H., Hu, Y. Development of fully bio-based pectin/curcumin@bio-MOF-11 for colon specific drug delivery. Chem. Pap. 76, 2969–2979 (2022). https://doi.org/10.1007/s11696-022-02081-8

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