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Effects of Sleeve Gastrectomy on Patients with Obesity and Polycystic Ovary Syndrome: a Meta-analysis

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Abstract

Purpose

This study aimed to evaluate the efficacy of sleeve gastrectomy (SG) on patients with obesity and polycystic ovary syndrome (PCOS).

Materials and Methods

We searched PubMed, Embase, Cochrane Library, and Web of Science to identify relevant studies published prior to December 2, 2022. Meta-analysis was performed on menstrual irregularity, total testosterone, sex hormone-binding globulin (SHBG), anti-Mullerian hormone (AMH), glucolipid metabolism indicators, and body mass index (BMI) following SG.

Results

Six studies and 218 patients were included in the meta-analysis. Following SG, menstrual irregularity significantly decreased (odds ratio [OR] 0.03; 95% confidence intervals [CIs], 0.00–0.24; P=0.001). Additionally, SG can lower total testosterone levels (MD −0.73; 95% CIs −0.86–0.60; P< 0.0001), as well as BMI (MD −11.59; 95% CIs −13.10–10.08; P<0.0001). A significant increase was observed in the levels of SHBG and high-density lipoprotein (HDL) after SG. In addition to reducing fasting blood glucose, insulin, triglycerides (TG), and low-density lipoprotein levels, SG significantly reduced low-density lipoprotein levels as well.

Conclusions

Following SG, we firstly demonstrated significant improvements in menstrual irregularity, testosterone and SHGB levels, glycolipid metabolism indicators, and BMI. Therefore, SG may be considered as a new option for the clinical treatment of patients with obesity and PCOS.

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Funding

This work was supported by the Wisdom Accumulation and Talent Cultivation Project of the Third Xiangya Hospital of Central South University (YX202102).

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Author notes

  1. Ping Luo and Zhihong Su have contributed equally to this work.

Authors and Affiliations

  1. Department of General Surgery, Third Xiangya Hospital, Central South University, Changsha, 410013, Hunan, China

    Ping Luo, Zhihong Su, Pengzhou Li, Guohui Wang, Weizheng Li, Xulong Sun, Zhibing Fu, Hui Zhou, Xianhao Yi, Liyong Zhu & Shaihong Zhu

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  1. Ping Luo
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Correspondence to Liyong Zhu or Shaihong Zhu.

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Key Points

1. We firstly performed a meta-analysis to evaluate the efficacy of sleeve gastrectomy on patients with obesity and PCOS;

2. Sleeve gastrectomy significantly improved the prevalence of menstrual irregularity, total testosterone level, glycolipid metabolism indicators, and body mass index in obese PCOS patients;

3. Sleeve gastrectomy may be considered as a new option for clinical practice in obese PCOS patients.

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Luo, P., Su, Z., Li, P. et al. Effects of Sleeve Gastrectomy on Patients with Obesity and Polycystic Ovary Syndrome: a Meta-analysis. OBES SURG 33, 2335–2341 (2023). https://doi.org/10.1007/s11695-023-06617-z

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