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RYGB Is More Effective than VSG at Protecting Mice from Prolonged High-Fat Diet Exposure: An Occasion to Roll Up Our Sleeves?

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Abstract

Purpose

Understanding the effects of Roux-en-Y gastric bypass (RYGB) and vertical sleeve gastrectomy (VSG) on adipose tissue physiology is important for the treatment of obesity-related metabolic disorders. By using robust mouse models of bariatric surgery that closely resemble those performed in humans, we can compare the effects of RYGB and VSG on adipose physiology in the absence of post-operative confounds such as diet and lifestyle changes.

Materials and Methods

RYGB and VSG were compared using a diet-induced mouse model of obesity. High-fat diet (HFD) was administered post-operatively and changes to white and brown adipose tissue were evaluated, along with alterations to weight, glucose homeostasis, dyslipidemia, and insulin sensitivity.

Results

After prolonged exposure to high-fat diet post-operatively, RYGB was effective in achieving sustained weight loss, while VSG unexpectedly accelerated weight gain rates. The resolution of obesity-related comorbidities such as glucose and insulin intolerance, dyslipidemia, and insulin sensitivity was improved after RYGB, but not for VSG. In RYGB, there were improvements to the function and health of white adipose tissue, enhanced brown adipose metabolism, and the browning of subcutaneous white adipose tissue, with no comparable changes seen for these factors after VSG. Some markers of systemic inflammation improved after both RYGB and VSG.

Conclusion

There are significantly different effects between RYGB and VSG when HFD is administered post-operatively and robust mouse models of bariatric surgery are used. RYGB resulted in lasting physiological and metabolic changes but VSG showed little difference from that of its sham-operated, DIO counterpart.

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Acknowledgements

We thank the animal care staff members for their help and kind support throughout the duration of the study.

Funding

This article is funded by The American Heart Association GIA Award #15GRNT22420001 and The George Link Foundation.

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Authors and Affiliations

  1. Department of Biomedical Research, NYU Long Island School of Medicine, NYU Langone Hospital—Long Island, 101 Mineola Blvd. Suite 4-003, Mineola, NY, 11501, USA

    Matthew Stevenson, Ankita Srivastava, Jenny Lee, Christopher Hall, Thomas Palaia & Louis Ragolia

  2. Department of Foundations of Medicine, NYU Long Island School of Medicine, 101 Mineola Blvd, Mineola, NY, 11501, USA

    Thomas Palaia & Louis Ragolia

  3. Department of Endocrinology, NYU Langone Hospital—Long Island, 101 Mineola Blvd. Suite 2-009, Mineola, NY, 11501, USA

    Raymond Lau

  4. Department of Surgery, NYU Langone Hospital—Long Island, 222 Station Plaza, Suite 300, Mineola, NY, 11501, USA

    Collin Brathwaite

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  1. Matthew Stevenson
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Correspondence to Louis Ragolia.

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Stevenson, M., Srivastava, A., Lee, J. et al. RYGB Is More Effective than VSG at Protecting Mice from Prolonged High-Fat Diet Exposure: An Occasion to Roll Up Our Sleeves?. OBES SURG 31, 3227–3241 (2021). https://doi.org/10.1007/s11695-021-05389-8

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