Abstract
Background
Bariatric surgery is associated with a reduced incidence of hyperuricaemia during the long follow-up time. However, few studies have elucidated the alterations in serum urate (SU) levels in the short-term post-surgery period.
Purpose
To identify the alterations in SU concentrations in individuals with obesity at 1 week, 1 month, and 3 months after bariatric surgery and determine the risk factors for alterations during the first 3 post-surgery months.
Methods
Thirty-four patients were enrolled. Pre- and post-operative variables were collected at baseline and at each follow-up point. A paired t-test was applied to investigate the relationship between the major parameters. A linear mixed model was performed to analyse the variations of SU concentrations with time.
Results
Compared with baseline levels, SU levels significantly increased at 1 week, then declined significantly at 1 month after surgery (P < 0.05). At the 3-month follow-up, a significant decrease in SU levels was detected compared with that in baseline levels (P < 0.001). In univariate regression analysis, age, sex, weight, body mass index, triglyceride (TG), total cholesterol (TC), creatinine (Cr), and medications were all risk factors for alterations in SU concentrations post-surgery. In the final model, sex, weight, Cr, age, TC, Cr * age, and Cr * TC were established.
Conclusions
Surgeons should be cognizant of the significant increase in SU levels in the first postoperative week. Alterations in SU concentrations during the first 3 post-operative months were associated with sex, age, weight, Cr, and TC levels at baseline.
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Acknowledgements
The authors would like to thank all of the involved study investigators, staffs, clinicians, nurses, and technicians for dedicating their time and skills to the completion of this study.
Funding
This study was supported by the National Key Technologies R&D Program (Grant No. 2015BAI13B09), National Key Technologies R&D Program of China (No. 2017YFC0110904), Beijing Excellent Talents Training Funding Program (Grant No. 2018000021469G195), and Capital’s Funds for Health Improvement and Research (No. 2020-1-2021).
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This study was performed in accordance with the principles of the Declaration of Helsinki and was approved by the Ethics Committees of Beijing Friendship Hospital, Capital Medical University.
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Li, M., Liu, Y., Zeng, N. et al. Alterations in the Serum Urate Concentrations after Bariatric Surgery: a Short-Term Prospective Observational Study. OBES SURG 31, 1688–1695 (2021). https://doi.org/10.1007/s11695-020-05181-0
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DOI: https://doi.org/10.1007/s11695-020-05181-0