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Roux-en-Y Gastric Bypass and Sleeve Gastrectomy Differently Affect Oxidative Damage Markers and their Correlations with Body Parameters

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Abstract

Background

Bariatric surgery improves oxidative damage, but little is known about the differences between Roux-en-Y gastric bypass (RYGB) and sleeve gastrectomy (SG). This study compared changes in lipid and protein oxidative damage markers and their correlations with body parameters of patients before and after RYGB or SG.

Methods

Body mass index (BMI), bioimpedance parameters, and biochemical parameters including lipid and protein oxidative damage markers were evaluated before and 6 months after surgery. Data were analyzed by t test or Mann-Whitney rank sum test and Spearman’s correlation coefficient between oxidative damage and other parameters.

Results

Twenty-five patients were submitted to RYGB and 14 to SG. There was a significant decrease of BMI, fat mass, fat-free mass, phase angle, serum total protein, transthyretin, and C-reactive protein in both groups (p < 0.05). Serum thiobarbituric acid reactive substances (TBARS), advanced oxidation protein products (AOPP), and serum lipids (p < 0.05) were significantly decreased in the RYGB group. TBARS levels were significantly correlated with serum total cholesterol (r = 0.468), LDL (r = 0.439), BMI (r = 0.424), and fat mass (r = 0.40) (p < 0.05). In the SG group, AOPP levels were significantly correlated with serum C-reactive protein (baseline: r = 0.53, 6 months: r = 0.64) (p < 0.05). Alterations in these levels were negatively correlated with changes in BIA parameters [resistance (r = −0.574), reactance (r = −0.736), and phase angle (r = 0.549)] (p < 0.05).

Conclusions

RYGB seems to be better in attenuating oxidative damage after 6 months. The BMI reduction in the RYGB group suggests a concomitant decrease of lipid oxidative damage. In the SG group, changes in BIA parameters were inversely correlated with protein oxidative damage.

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Acknowledgments

We thank the National Council for Scientific and Technological Development (CNPQ), Coordination for the Improvement of Higher Education Personnel (CAPES), Espírito Santo Research and Innovation Support Foundation (FAPES), and the Federal University of Espírito Santo (UFES). We are also indebted to Cassiano Antônio de Moraes University Hospital (HUCAM).

Contributing Authors

Conceptualization: FKH, GPSM, RGP; Methodology: FKH, GPSM, RGP; Investigation and Formal Analysis: FAV, LAA, PVCZ, VGB; Resources: FKH, GPSM, RGP; Data Curation: FKH, FAV; Writing – Original Draft Preparation: FKH, FAV; Writing – Review & Editing, FKH, FAV, GPSM, RGP, LAA, PVCZ, VGB; Supervision: FKH, RGP; Project Administration: FKH, RGP; Funding Acquisition: FKH, RGP.

Funding

This study received financial support from the Espírito Santo Research and Innovation Support Foundation (FAPES, Portuguese: Fundação de Amparo à Pesquisa e Inovação do Espírito Santo) grant #151/2019 – Universal/FAPES and grant #85198560 – PPP/FAPES, and by a partial scholarship granted to LAA.

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Authors and Affiliations

  1. Postgraduate Program in Nutrition and Health (PPGNS), Federal University of Espírito Santo (UFES), Marechal Campos Ave, 1468, Maruípe, 29040-090, Vitória, Espírito Santo, Brazil

    Fernanda A. Venâncio, Leandra A. Almeida, Rogerio G. Pedrosa & Fabiano K. Haraguchi

  2. Department of Physiological Sciences, Federal University of Espírito Santo (UFES), Marechal Campos Ave, 1468, Maruípe, 29040-090, Vitória, Espírito Santo, Brazil

    Paulo V. Zovico & Valério G. Barauna

  3. Department of Surgical Clinic, Federal University of Espírito Santo (UFES), Marechal Campos Ave, 1468, Maruípe, 29040-090, Vitória, Espírito Santo, Brazil

    Gustavo P. S. Miguel

  4. Department of Integrated Education in Health (DEIS), Federal University of Espírito Santo (UFES), Marechal Campos Ave, 1468, Maruípe, 29040-090, Vitória, Espírito Santo, 29040-090, Brazil

    Rogerio G. Pedrosa & Fabiano K. Haraguchi

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  1. Fernanda A. Venâncio
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  2. Leandra A. Almeida
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  7. Fabiano K. Haraguchi
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Correspondence to Fabiano K. Haraguchi.

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The authors declare that they have no conflicts of interest.

Ethical Approval Statement

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards. The study was approved by the hospital’s Ethics Committee (#51519115.7.0000.5071).

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Venâncio, F.A., Almeida, L.A., Zovico, P.V. et al. Roux-en-Y Gastric Bypass and Sleeve Gastrectomy Differently Affect Oxidative Damage Markers and their Correlations with Body Parameters. OBES SURG 31, 1680–1687 (2021). https://doi.org/10.1007/s11695-020-05179-8

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