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Glucose-Lipid Metabolism in Obesity with Elevated Prolactin Levels and Alteration of Prolactin Levels After Laparoscopic Sleeve Gastrectomy

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Abstract

Purpose

We investigated the differences in metabolism between obesity with or without increased prolactin (PRL) and the change in PRL after laparoscopic sleeve gastrectomy (LSG).

Methods

Patients were divided into two groups: obesity with normal PRL (NP, n = 123) and high PRL (HP, n = 108). Glucose-lipid metabolism and inflammation were measured. A total of 115 patients with obesity (NP, n = 64; HP, n = 51) underwent LSG were recruited, and PRL was measured at 12 months after LSG.

Results

(1) Blood glucose (BG), total cholesterol (TCH), LDL, triglyceride, and TNF-α were lower in the HP than in the NP group in the cross-sectional study (all P < 0.05). (2) PRL was negatively associated with neck circumference, waist-to-hip ratio, systolic blood pressure, heart rate, basal metabolism rate (BMR), ALP, TCH, and LDL in all subjects. PRL levels were positively associated with weight, HC, and BMR in males but were negatively associated with ALT, AST, ALP, BG 30 min, BG 60 min, FFA, and TCH in females (all P < 0.05). (3) Regression analysis showed that PRL negatively correlated with ALP and LDL-C in the whole baseline (β = − 0.051, P = 0.002; β = − 1.372, P = 0.033). PRL was a negative factor for ALP in females and a positive factor for BMR2 in males (β = − 0.099, P = 0.041; β = 0.005, P = 0.006). (4) PRL decreased in the HP group and increased in the NP group at 12 months post-operation (all P < 0.05). Increased PRL was associated with a change in TCH in the NP group (P < 0.05).

Conclusion

Increased PRL resulted in improved glucose-lipid metabolism and chronic low-grade inflammation. LSG led to increased PRL in NP and decreased PRL in HP. Improved lipid was associated with increased PRL in NP after surgery.

Clinical Trial Registration Number

ChiCTR-OCS-12002381.

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Funding

The authors received the financial support from the National Key R&D Program of China (Nos. 2018YFC1314100, 2016YFC1305600) and Shanghai Municipality: Shanghai Outstanding Academic Leaders Plan (049).

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Authors and Affiliations

  1. Department of Endocrinology and Metabolism, School of Medicine, Shanghai Tenth People’s Hospital of Tongji University, No. 301 Middle Yanchang Road, Shanghai, 200072, China

    Xingchun Wang, Bingwei Ma, Guifang Li, Chunjun Sheng, Peng Yang, Jingyang Gao & Shen Qu

  2. Thyroid Research Center of Shanghai, Shanghai, 200072, China

    Xingchun Wang, Chunjun Sheng, Peng Yang & Shen Qu

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  1. Xingchun Wang
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  2. Bingwei Ma
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Correspondence to Shen Qu.

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The authors declare that they have no conflict of interest.

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Informed consent was obtained from all individual participants included in the study.

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All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

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Xingchun Wang, Bingwei Ma, and Guifang Li are co-first authors.

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Wang, X., Ma, B., Li, G. et al. Glucose-Lipid Metabolism in Obesity with Elevated Prolactin Levels and Alteration of Prolactin Levels After Laparoscopic Sleeve Gastrectomy. OBES SURG 30, 4004–4013 (2020). https://doi.org/10.1007/s11695-020-04771-2

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  • DOI: https://doi.org/10.1007/s11695-020-04771-2

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