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Syndrome métabolique : une histoire d’empreinte nutritionnelle et d’épigénétique ?

Metabolic syndrome: nutritional imprinting and epigenetics

  • Dossier Thématique / Thematic File
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Résumé

L’observation d’un lien entre intensité de croissance périnatale et risque de développer des maladies métaboliques à l’âge adulte a fait émerger la notion dite « d’empreinte métabolique ». La nutrition, pendant les stades précoces de la vie, conditionnerait certaines fonctions métaboliques de façon durable et éventuellement transmissible aux générations suivantes. Les nutriments exerceraient une régulation directe de l’expression du génome par des modifications épigénétiques. Cependant, à ce jour, ces données expérimentales sont obtenues sur des modèles animaux et nécessitent d’être confirmées par des recherches chez l’homme.

Abstract

The concept of metabolic imprinting developed from the observation of a relationship between perinatal growth rate and the risk of late onset metabolic disease. According to this concept, early nutrition could influence a number of key metabolic pathways in the long term, and this influence could even be in some way transmitted to future generations. As demonstrated in animal models, nutrients could act on secondary genomic structure and expression through epigenetic mechanisms. Further studies of human populations are needed to confirm this hypothesis.

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Authors and Affiliations

  1. Institut national de la recherche agronomique, Centre de recherche de Nantes, UMR 1280 INRA-Université de Nantes, Rue de la Géraudière, PB 71627, F-44316, Nantes Cedex 3, France

    P. Parnet, F. Bolaños-Jimenez & V. Amarger

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  1. P. Parnet
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  2. F. Bolaños-Jimenez
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  3. V. Amarger
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Correspondence to P. Parnet.

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Parnet, P., Bolaños-Jimenez, F. & Amarger, V. Syndrome métabolique : une histoire d’empreinte nutritionnelle et d’épigénétique ?. Obes 2, 158–165 (2007). https://doi.org/10.1007/s11690-007-0048-6

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  • DOI: https://doi.org/10.1007/s11690-007-0048-6

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