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Schistosoma japonicum Associated Colorectal Cancer and Its Management

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Abstract

Background

An association between Schistosoma japonicum and colorectal cancer in humans has been known since a long time; however, this association remains understudied and lacks comprehensive experimentation support.

Objective

Various epidemiological and pathological studies have established the role of chronic inflammation as a major factor behind the induction of colorectal cancer. The aim of this review is to present the current knowledge on the association of Schistosoma japonicum with colorectal cancer.

Result

Mechanisms which lead to induction and progression of colorectal cancer are highlighted along with diagnosis and treatment for the same. Further, various methodologies, including mass drug administration, use of new drugs and vaccines, role of apoptosis, and histone-modifying enzymes, have been described which can either prevent the schistosomal infection itself or can check it from reaching an advanced stage.

Conclusions

Epidemiological, clinical, pathological and surgical studies suggest that Schistosoma japonicum is responsible for induction of colorectal cancer. However, thorough clinical studies are required to support and globally accept this notion. Further, methodologies highlighted in this work can be employed in order to take care of schistosomal infection or address the cancer induction and progression.

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Data Availability

Data sharing is not applicable to this article as no datasets were generated in the current review.

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Authors and Affiliations

  1. Institute for Globally Distributed Open Research and Education (IGDORE), Rewari, Haryana, India

    Sidhant Jain

  2. Dyal Singh College, University of Delhi, Lodhi Road, Pragati Vihaar, New Delhi, 110003, India

    Meenakshi Rana

  3. Department of Zoology, Gate No. 3, Chaatra Marg, University of Delhi, North Campus, Delhi, 110007, India

    Pooja Choubey

  4. Department of Pharmacology, ESIC Dental College and Hospital, Rohini, Sector-15, Delhi, 110089, India

    Sahil Kumar

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  1. Sidhant Jain
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  2. Meenakshi Rana
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  3. Pooja Choubey
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  4. Sahil Kumar
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Conceptualization of idea: SJ; data collection: SJ, MR, PC, and SK; drafting: SJ, MR, and SK; figures: SJ and MR; review and critical analysis: SJ, MR, PC, and SK.

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Jain, S., Rana, M., Choubey, P. et al. Schistosoma japonicum Associated Colorectal Cancer and Its Management. Acta Parasit. 68, 723–734 (2023). https://doi.org/10.1007/s11686-023-00707-9

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