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Discovery of the mechanisms of acupuncture in the treatment of migraine based on functional magnetic resonance imaging and omics

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Abstract

Migraine is one of the most prevalent and disabling neurological disease, but the current pharmacotherapies show limited efficacy and often accompanied by adverse effects. Acupuncture is a promising complementary therapy, but further clinical evidence is needed. The influence of acupuncture on migraine is not an immediate effect, and its mechanism remains unclear. This study aims to provide further clinical evidence for the anti-migraine effects of acupuncture and explore the mechanism involved. A randomized controlled trial was performed among 10 normal controls and 38 migraineurs. The migraineurs were divided into blank control, sham acupuncture, and acupuncture groups. Patients were subjected to two courses of treatment, and each treatment lasted for 5 days, with an interval of 1 day between the two courses. The effectiveness of treatment was evaluated using pain questionnaire. The functional magnetic resonance imaging (fMRI) data were analyzed for investigating brain changes induced by treatments. Blood plasma was collected for metabolomics and proteomics studies. Correlation and mediation analyses were performed to investigate the interaction between clinical, fMRI and omics changes. Results showed that acupuncture effectively relieved migraine symptoms in a way different from sham acupuncture in terms of curative effect, affected brain regions, and signaling pathways. The anti-migraine mechanism involves a complex network related to the regulation of the response to hypoxic stress, reversal of brain energy imbalance, and regulation of inflammation. The brain regions of migraineurs affected by acupuncture include the lingual gyrus, default mode network, and cerebellum. The effect of acupuncture on patients’ metabolites/proteins may precede that of the brain.

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Acknowledgements

This work was supported by grants from the Ten Thousand Talents Project of the Ministry of Science and Technology, the Young Qihuang Scholars Project of the National Administration of Traditional Chinese Medicine Program and the Beijing Young Talents Program. We thank Yulong Li from Peking University School of Life Sciences as well as scientists in his laboratory for helpful discussions and viewpoints.

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  1. These authors contributed equally to this work.

Authors and Affiliations

  1. Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing, 100700, China

    Chong Li, Xinyi Li, Ke He, Yang Wu, Xiaoming Xie, Jiju Yang, Fan Zhang, Yang Yue & Guihua Tian

  2. Department of Integration of Chinese and Western Medicine, Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Peking University Cancer Hospital & Institute, Beijing, 100142, China

    Huifeng Hao

  3. State Key Laboratory of Cognitive Neuroscience and Learning, Beijing Normal University, Beijing, 100875, China

    Shaokun Zhao & Xin Li

Authors
  1. Chong Li
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  2. Xinyi Li
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  3. Ke He
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  4. Yang Wu
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  5. Xiaoming Xie
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  6. Jiju Yang
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  7. Fan Zhang
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  8. Yang Yue
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  9. Huifeng Hao
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  10. Shaokun Zhao
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  11. Xin Li
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  12. Guihua Tian
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Corresponding author

Correspondence to Guihua Tian.

Ethics declarations

Chong Li, Xinyi Li, Ke He, Yang Wu, Xiaoming Xie, Jiju Yang, Fan Zhang, Yang Yue, Huifeng Hao, Shaokun Zhao, Xin Li, and Guihua Tian declare that they have no conflict of interest. All procedures followed were in accordance with the ethical standards of the responsible committee on human experimentation (institutional and national) and with the Helsinki Declaration of 1975, as revised in 2000. Informed consent was obtained from all patients for being included in the study. The study was approved by the Ethics Committee of the Beijing University of Chinese Medicine (DZMEC-KY-2018-44).

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Li, C., Li, X., He, K. et al. Discovery of the mechanisms of acupuncture in the treatment of migraine based on functional magnetic resonance imaging and omics. Front. Med. 17, 993–1005 (2023). https://doi.org/10.1007/s11684-023-0989-7

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  • DOI: https://doi.org/10.1007/s11684-023-0989-7

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