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Alternations of interhemispheric functional connectivity in patients with optic neuritis using voxel-mirrored homotopic connectivity: A resting state fMRI study

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Abstract

Background and purpose

We used the voxel-mirrored homotopic connectivity (VMHC) method to investigate brain interhemispheric functional connectivity changes in patients with optic neuritis (ON).

Methods

A total of 22 ON patients and 22 healthy controls (HCs) closely matched in age, sex, and weight were enrolled. All participants underwent resting-state functional magnetic resonance imaging (rs-fMRI). Functional interaction between the hemispheres was assessed with the VMHC method. Correlation analysis was applied to explore the association between altered VMHC values in different brain areas and cognitive features. Receiver operating characteristic (ROC) curve analysis was applied to distinguish ON patients from HCs.

Results

Compared with HCs, ON patients had obviously reduced VMHC values in the right superior temporal gyrus, left margin superior gyrus, right superior motor cortex, and left middle cingulate gyrus. a negative relationship between best-corrected visual acuity and VMHC values in left margin superior gyrus was found, besides, the VMHC values within the right superior motor cortex and the right superior temporal gyrus were also anti-correlated with the Hamilton Depression Scales. The ROC curve displayed high diagnostic values in those altered regions.

Conclusion

Abnormal VMHC values may reflect the underlying neuropathologic mechanism of ON.

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Data Availability

The data that support the findings of this study are available from the corresponding author upon reasonable request.

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Acknowledgements and Disclosure

This study is supported by National Natural Science Foundation of China (No: 81660158, 81460092, 81400372); Natural Science Key Project of Jiangxi Province (No: 20161ACB21017); Health Development Planning Commission Science Foundation of Jiangxi Province (No: 20175116); and Research Incubation Fund of Xi’an People’s Hospital(Xi’an Fourth Hospital)(FZ-45). There are no conflicts of interest.

Funding

The study was supported by grants from the National Natural Science Foundation of China (Nos. 81660158, 81460092, and 81400372); Natural Science Key Project of Jiangxi Province (No. 20161ACB21017); and Health Development Planning Commission Science Foundation of Jiangxi Province (No. 20175116). The funding organizations play no further role in study design, data collection, analysis and interpretation and paper writing.

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Authors and Affiliations

  1. Scientific Research Department, Xi’an People’s Hospital (Xi’an Fourth Hospital), 710004, Xi’an, Shaanxi Province, China

    Ke Song

  2. Department of Neurology, Xi’an People’s Hospital (Xi’an Fourth Hospital), 710004, Xi’an, Shaanxi Province, China

    Ya-Li Lv

  3. Department of Radiology, Xi’an People’s Hospital (Xi’an Fourth Hospital), 710004, Xi’an, Shaanxi Province, China

    Li-juan Yang, Peng Lv, Bo Ren, Jun Tian & Dao-qing Wei

  4. Department of Obstetrics, Xi’an People’s Hospital (Xi’an Fourth Hospital), 710004, Xi’an, Shaanxi Province, China

    Huan Li

  5. Department of ophthalmology , The First Affiliated Hospital of Nanchang University, 330006, Nanchang, Shaanxi Province, China

    Yi Shao

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  1. Ke Song
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Contributions

Huan Li and Yi Shao designed the study; Li-juan Yang contributed to data sources and study selection; Peng Lv contributed to data acquisition; Bo Ren contributed to data analysis; Ke Song, and Jun Tian wrote the manuscript; Dao-Qing Wei, Ya-Li Lv revised the manuscript. All authors contributed to and have approved the final manuscript. We thank all the authors of the included studies who responded to our requests for further information.

Corresponding authors

Correspondence to Huan Li or Yi Shao.

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Ethical approval

This study was approved by the Ethics Committee of First Affiliated Hospital of Nanchang University Hospital, Nanchang, China.

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The authors have declared that no competing interest exists.

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Song, K., Lv, YL., Yang, Lj. et al. Alternations of interhemispheric functional connectivity in patients with optic neuritis using voxel-mirrored homotopic connectivity: A resting state fMRI study. Brain Imaging and Behavior 17, 1–10 (2023). https://doi.org/10.1007/s11682-022-00719-5

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