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Clinical study of t-PA and u-PA expression in patients with gastrointestinal cancer

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Chinese Journal of Cancer Research

Abstract

Objective: To study the changes of tissue-type plasminogen activator (t-PA), urokinase-type plasminogen activator (u-PA) expressions and fibrinolysis molecular markers in patients with gastrointestinal cancer in order to elucidate their clinical significance. Methods: The plasma levels of t-PA, u-PA, urokinase-type plasminogen activator receptor (u-PAR) and plasmin anti-plasmin complex (PAP) were measured by ELISA. t-PA and u-PA mRNAs were detected by Real-time RT-PCR. Results: The plasma levels of u-PA, u-PAR and PAP were elevated in gastrointestinal cancer patients, while u-PA was markedly elevated in patients with local infiltration, lymph node involvement or distal metastasis. U-PA mRNA was higher and t-PA was lower in gastrointestinal cancer compared to normal tissue. Conclusion: Hyperfibrinolysis is an important factor related with metastasis potential of gastrointestinal cancer. t-PA may be a character of well differentiated tissue.

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Authors and Affiliations

  1. Department of Internal Medicine, Ruijin Hospital, Shanghai Second Medical University, 200025, Shanghai

    Wu Fang, Qu Bin, Gong Yun-xia, Wang Xue-feng, Yang Chen-min & Wang Hong-li

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  1. Wu Fang
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  2. Qu Bin
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  3. Gong Yun-xia
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  4. Wang Xue-feng
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  5. Yang Chen-min
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  6. Wang Hong-li
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Corresponding author

Correspondence to Wang Hong-li.

Additional information

Biography: WU Fang(1965–), female, master of medicine, associate professor, Shanghai Second Medical University, majors in internal medicine.

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Wu, F., Qu, B., Gong, Yx. et al. Clinical study of t-PA and u-PA expression in patients with gastrointestinal cancer. Chin. J. Cancer Res. 17, 97–102 (2005). https://doi.org/10.1007/s11670-005-0051-0

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  • DOI: https://doi.org/10.1007/s11670-005-0051-0

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