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Circulating platelet concentration is associated with bone mineral density in women

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Abstract

Summary

In this cross-sectional study, enrollment included 818 female adults undergoing bone mineral density (BMD) assessment during the health examination. Subjects with osteoporosis had the lowest circulating platelet concentrations. The circulating platelet concentration was positively correlated with BMD. A high platelet concentration had independently low odds of osteoporosis.

Purpose

Platelets play an important role in bone metabolism. However, the association between circulating platelet counts and bone mineral density (BMD) has been inconsistently reported. We aimed to investigate the relationship between platelet counts and osteoporosis in Chinese women.

Methods

In this cross-sectional study, a total of 818 female adults who underwent BMD assessment during the health examination were enrolled. Blood cell counts and biochemistry data were recorded.

Results

Subjects with osteoporosis had the lowest platelet counts (238 ± 59 × 109/L) compared with subjects with osteopenia (256 ± 64 × 109/L) and a normal BMD (269 ± 76 × 109/L, P < 0.001). The circulating platelet concentration was positively correlated with the BMD of the lumbar spine (r = 0.195, P < 0.001), left hip (r = 0.145, P < 0.001), and right hip (r = 0.149, P < 0.001). According to the receiver operating characteristic curve, the cutoff platelet concentration for differentiating osteoporosis was 260 × 109/L. A high platelet concentration had significantly low odds of osteoporosis after adjusting for other covariates (odds ratio = 0.574, 95% confidence interval: 0.346‒0.953, P = 0.032).

Conclusion

The circulating platelet concentration was significantly correlated with BMD in Chinese women.

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Acknowledgements

We thank the Health Management Center database and Clinical Informatics Research & Development Center in Taichung Veterans General Hospital.

Funding

This work was supported by grants from Taichung Veterans General Hospital, Taichung, Taiwan (grant number TCVGH-1103503C), and the Ministry of Science and Technology, Taiwan (grant number MOST 110–2314-B-075A-004-MY3). The funders had no role in the decision to submit the manuscript for publication.

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Authors and Affiliations

  1. Division of Endocrinology and Metabolism, Department of Internal Medicine, Taichung Veterans General Hospital, Taichung, 407, Taiwan

    Wei-Chun Ma, Yu-Cheng Cheng, Yu-Hsuan Li & I-Te Lee

  2. School of Medicine, National Yang Ming Chiao Tung University, Taipei, 112, Taiwan

    Yu-Cheng Cheng, Yu-Hsuan Li & I-Te Lee

  3. Department of Medical Research, Taichung Veterans General Hospital, Taichung, 407, Taiwan

    Wen-Jane Lee

  4. Department of Computer Science & Information Engineering, National Taiwan University, Taipei, 106, Taiwan

    Yu-Hsuan Li

  5. School of Medicine, Chung Shan Medical University, Taichung, 402, Taiwan

    I-Te Lee

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  1. Wei-Chun Ma
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Correspondence to I-Te Lee.

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The Institutional Review Board of Taichung Veterans General Hospital approved the research protocol (IRB TCVGH No: CE17234A).

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All data on patients in this retrospective study were anonymously provided by Clinical Informatics Research & Development Center in Taichung Veterans General Hospital. The need for informed consent was waived.

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Ma, WC., Cheng, YC., Lee, WJ. et al. Circulating platelet concentration is associated with bone mineral density in women. Arch Osteoporos 17, 44 (2022). https://doi.org/10.1007/s11657-022-01089-7

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