Abstract
Objective
To derive the Chinese medicine (CM) syndrome classification and subgroup syndrome characteristics of ischemic stroke patients.
Methods
By extracting the CM clinical electronic medical records (EMRs) of 7,170 hospitalized patients with ischemic stroke from 2016 to 2018 at Weifang Hospital of Traditional Chinese Medicine, Shandong Province, China, a patient similarity network (PSN) was constructed based on the symptomatic phenotype of the patients. Thereafter the efficient community detection method BGLL was used to identify subgroups of patients. Finally, subgroups with a large number of cases were selected to analyze the specific manifestations of clinical symptoms and CM syndromes in each subgroup.
Results
Seven main subgroups of patients with specific symptom characteristics were identified, including M3, M2, M1, M5, M0, M29 and M4. M3 and M0 subgroups had prominent posterior circulatory symptoms, while M3 was associated with autonomic disorders, and M4 manifested as anxiety; M2 and M4 had motor and motor coordination disorders; M1 had sensory disorders; M5 had more obvious lung infections; M29 had a disorder of consciousness. The specificity of CM syndromes of each subgroup was as follows. M3, M2, M1, M0, M29 and M4 all had the same syndrome as wind phlegm pattern; M3 and M0 both showed hyperactivity of Gan (Liver) yang pattern; M2 and M29 had similar syndromes, which corresponded to intertwined phlegm and blood stasis pattern and phlegm-stasis obstructing meridians pattern, respectively. The manifestations of CM syndromes often appeared in a combination of 2 or more syndrome elements. The most common combination of these 7 subgroups was wind-phlegm. The 7 subgroups of CM syndrome elements were specifically manifested as pathogenic wind, pathogenic phlegm, and deficiency pathogens.
Conclusions
There were 7 main symptom similarity-based subgroups in ischemic stroke patients, and their specific characteristics were obvious. The main syndromes were wind phlegm pattern and hyperactivity of Gan yang pattern.
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Acknowledgement
WE appreciate Beijing Zhong Teng Bai Mai Medical Technology Co. Ltd. very much for data processing.
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Liu XQ contributed to analysis, interpretation of data, and original draft preparation. Zhang RS and Zhou XZ contributed to data acquisition and interpretation of data. Zhou H and Zhang LZ assisted in the review of raw data. Shu ZX, Ji JH and Zhong Q helped with the computer extraction of the data. Zhang XB, Zhang LL, Mou ZJ, He LY, and Yang J advanced data processing and meeting process recording. Chen ZG, Li XZ, Zhang W, Tan Y, Yan ZF, Hu YJ and Meng W gave some suggestions in the revision of the manuscript. Zhong LQ and Cao KG participated in the evaluation of CM syndromes and syndrome elements. He YY, Han S, Zhang J and Zhao H participated in the collation and correction of original data. Li XZ and Zhong LQ helped standardize English expression. Zhong LQ reviewed and revised the manuscript. All authors contributed to the article and approved the submitted version.
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Supported by the National Key Research and Development Program (No. 2017YFC1703502 and 2017YFC1703506)
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Liu, Xq., Zhang, Rs., Zhou, Xz. et al. Analysis of Chinese Medical Syndrome Features of Ischemic Stroke Based on Similarity of Symptoms Subgroup. Chin. J. Integr. Med. 29, 441–447 (2023). https://doi.org/10.1007/s11655-022-3571-2
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DOI: https://doi.org/10.1007/s11655-022-3571-2