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Roles of Gut Microbiota in Pathogenesis of Alzheimer’s Disease and Therapeutic Effects of Chinese Medicine

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Abstract

Alzheimer’s disease (AD) is the most common neurodegenerative disease characterized by progressive cognitive impairment. The pathogenesis of AD is complex, and its susceptibility and development process are affected by age, genetic and epigenetic factors. Recent studies confirmed that gut microbiota (GM) might contribute to AD through a variety of pathways including hypothalamic pituitary adrenal axis and inflflammatory and immune processes. CM formula, herbs, and monomer enjoy unique advantages to treat and prevent AD. Hence, the purpose of this review is to outline the roles of GM and its core metabolites in the pathogenesis of AD. Research progress of CMs regarding the mechanisms of how they regulate GM to improve cognitive impairment of AD is also reviewed. The authors tried to explore new therapeutic strategies to AD based on the regulation of GM using CM.

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Authors and Affiliations

  1. School of Integrative Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin, 301617, China

    Ying-xin Sun, Xi-juan Jiang, Bin Lu, Qing Gao, Ye-fei Chen, Dan-bin Wu, Wen-yun Zeng, Lin Yang, Hu-hu Li & Bin Yu

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  1. Ying-xin Sun
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  2. Xi-juan Jiang
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  3. Bin Lu
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  4. Qing Gao
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  8. Lin Yang
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  9. Hu-hu Li
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Correspondence to Bin Yu.

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Supported by National Natural Science Foundation of China (No. 81704004), Scientific and Technological Research Program of Tianjin Municipal Education Commission (No. 2018KJ031), Research and Innovation Project of Graduate (No. YJSKC-20191003, No. ZXYCXLX201804)

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Sun, Yx., Jiang, Xj., Lu, B. et al. Roles of Gut Microbiota in Pathogenesis of Alzheimer’s Disease and Therapeutic Effects of Chinese Medicine. Chin. J. Integr. Med. 28, 1048–1056 (2022). https://doi.org/10.1007/s11655-020-3274-5

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