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Effect of modified Zhuye Shigao Decoction (加味竹叶石膏汤) and its components on preventing radiation esophagitis of rats

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Abstract

Objective

To investigate the effect of Modified Zhuye Shigao Decoction (加味竹叶石膏汤, MZSD) and its components on preventing radiation esophagitis of rats.

Methods

One hundred Wistar rats were randomly divided into 5 groups, including the control group, radiation model group, MZSD group, Zhuye Shigao Decoction (竹叶石膏汤, ZSD) group, and added ingredients group, 20 rats in each group. The model of radiation esophagitis of rat was established by once local radiation of 40 Gy (330 Mu/min) with a high energy linear accelerator. The administration of Chinese medicine was continued for 14 days from 7 days before radiation application in the three treatment groups. On the 7th and 14th day, the serum was isolated and the levels of inflammatory cytokines tumor necrosis factor (TNF-α), interleukin 1β (IL-1β) and IL-8 were tested. The pathological slices of esophagus were obtained, and the pathological changes were observed. During the whole process, weight and food intake were recorded each day.

Results

On the 7th day after radiation, the esophagus of rats in the MZSD group was almost intact, and the pathological injury score was significantly lower than that of the radiation model group, ZSD group and added ingredients group (P<0.01). Compared with the control group, the body weight and food intake of rats in the radiation model group were significantly decreased, and the levels of TNF-α, IL-1β and IL-8 were significantly increased (P<0.05 or P<0.01), while the MZSD group showed a significant increase in body weight and food intake, and a significant decrease in the levels of TNF-α, IL-1β and IL-8 compared with the radiation model group, ZSD group and added ingredients group (P <0.05 or P<0.01).

Conclusion

MZSD prevents the development of radiation esophagitis probably by inhibiting the generation and release of the inflammatory cytokines TNF-α, IL-1β and IL-8.

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Authors and Affiliations

  1. Department of Chinese Medicine, Chinese PLA General Hospital, Beijing, 100853, China

    Jun-zhang Lu  (路军章), Chen Wang  (王 琛), Ming-hui Yang  (杨明会), Hong Zhao  (赵 红) & Yi Liu  (刘 毅)

  2. Department of Medical Statistics, Chinese PLA General Hospital, Beijing, 100853, China

    Xiu-tang Cao  (曹秀堂)

Authors
  1. Jun-zhang Lu  (路军章)
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  2. Chen Wang  (王 琛)
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  3. Ming-hui Yang  (杨明会)
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  4. Hong Zhao  (赵 红)
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  5. Yi Liu  (刘 毅)
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  6. Xiu-tang Cao  (曹秀堂)
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Corresponding author

Correspondence to Jun-zhang Lu  (路军章).

Additional information

Supported by the National Natural Science Foundation of China (No. 81173195), and Capital Medical Development Fund, China (No. SF-2009-III-45)

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Lu, Jz., Wang, C., Yang, Mh. et al. Effect of modified Zhuye Shigao Decoction (加味竹叶石膏汤) and its components on preventing radiation esophagitis of rats. Chin. J. Integr. Med. 20, 462–467 (2014). https://doi.org/10.1007/s11655-014-1754-1

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  • DOI: https://doi.org/10.1007/s11655-014-1754-1

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