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In vitro bactericidal activity of jinghua weikang capsule (荆花胃康胶丸) and its individual herb Chenopodium Ambrosioides L. against antibiotic-resistant Helicobacter Pylori

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Abstract

Objective

To investigate the bactericidal effects of Jinghua Weikang Capsule (荆花胃康胶丸) and its major component Chenopodium ambrosioides L. on antibiotic-resistant Helicobacter pylori.

Methods

Four clinical antibiotic-resistant H. pylori strains were isolated and incubated in liquid medium containing Jinghua Weikang Capsule or Chenopodium ambrosioides L. By means of time-kill curve method, the average colony counts and bactericidal rate were calculated at time points of 0, 4, 8 and 24 h after the incubation and the time-kill curves were charted.

Results

Both Jinghua Weikang Capsule and Chenopodium ambrosioides L. at a concentration of 0.64 g/L showed obvious bactericidal effect against antibiotic-resistant H. pylori after 4 h of incubation.

Conclusion

Jinghua Weikang Capsule and Chenopodium ambrosioides L. are considered to be active against antibiotic-resistant H. pylori in vitro.

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Authors and Affiliations

  1. Department of Tradional Chinese Medicine and Integrated Tradional Chinese and Western Medicine, Peking University First Hospital, Beijing, 100034, China

    Wei Liu  (刘 伟), Xue-zhi Zhang  (张学智) & Ning Li  (李 宁)

  2. Dongzhimen Hospital Affiliated to Beijing University of Chinese Medicine, Beijing, 100029, China

    Yu Liu  (刘 宇)

  3. Department of Gastroenterology, Peking University First Hospital, Beijing, 100034, China

    Hong Cheng  (成 虹)

Authors
  1. Wei Liu  (刘 伟)
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  2. Yu Liu  (刘 宇)
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  3. Xue-zhi Zhang  (张学智)
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  4. Ning Li  (李 宁)
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  5. Hong Cheng  (成 虹)
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Corresponding author

Correspondence to Xue-zhi Zhang  (张学智).

Additional information

Supported by Capital Medical Development and Research Foundation (No. SF-2007-III-01) and National Natural Science Foundation of China (No. 8107295)

These authors contributed equally to this work

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Liu, W., Liu, Y., Zhang, Xz. et al. In vitro bactericidal activity of jinghua weikang capsule (荆花胃康胶丸) and its individual herb Chenopodium Ambrosioides L. against antibiotic-resistant Helicobacter Pylori . Chin. J. Integr. Med. 19, 54–57 (2013). https://doi.org/10.1007/s11655-012-1248-y

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  • DOI: https://doi.org/10.1007/s11655-012-1248-y

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