Abstract
Background
Vitamin D deficiency, an important risk factor for osteoporosis and other chronic medical conditions, is epidemic in the United States. Uninsured women may be at an even higher risk for vitamin D deficiency than others owing to low intake of dietary and supplemental vitamin D and limited sun exposure.
Objective
Our goal was to determine the prevalence of vitamin D deficiency in this vulnerable population.
Setting and Participants
We enrolled 145 uninsured women at a County Free Medical Clinic in urban Michigan. Questionnaires were used to obtain information about demographics, medical history, vitamin supplementation, sunlight exposure, and dietary vitamin D intake.
Results
The 96 women who were tested for vitamin D status ranged in age from 21 to 65 years (mean 48 ± 11), and 67% were vitamin D deficient as indicated by a 25-hydroxyvitamin D [25(OH)D)] level <50 nmol/L (20 ng/mL). Non-Caucasians were 3 times more likely than Caucasians to be vitamin D deficient (P = .049). Mean dietary vitamin D intake was low (125 ± 109 IU/d) and only 24% of the participants used any supplemental vitamin D. Participants with total vitamin D intake <400 IU/day from diet and supplements were 10 times more likely to be vitamin D deficient than others (P < .001).
Conclusions
These results demonstrate a high prevalence of vitamin D deficiency in an uninsured, medically underserved female population. Uninsured women should be strongly encouraged to increase their vitamin D intake.
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References
Bone Health and Osteoporosis: A Report of the Surgeon General. Available at: http://www.surgeongeneral.gov/library/bonehealth/docs/exec_summ.pdf.
Tangpricha V, Pearce EN, Chen TC, Holick MF. Vitamin D insufficiency among free-living healthy young adults. Am J Med. 2002;112(8):659–62.
Nesby-O’Dell S, Scanlon KS, Cogswell ME, et al. Hypovitaminosis D prevalence and determinants among African American and white women of reproductive age: third National Health and Nutrition Examination Survey, 1988–1994. Am J Clin Nutr. 2002;76(1):187–92.
Harris SS, Soteriades E, Coolidge JA, Mudgal S, Dawson-Hughes B. Vitamin D insufficiency and hyperparathyroidism in a low income, multiracial, elderly population. J Clin Endocrinol Metab. 2000;85(11):4125–30.
Plotnikoff GA, Quigley JM. Prevalence of severe hypovitaminosis D in patients with persistent, nonspecific musculoskeletal pain. Mayo Clin Proc. 2003;78(12):1463–70.
Lips P. Vitamin D deficiency and secondary hyperparathyroidism in the elderly: consequences for bone loss and fractures and therapeutic implications. Endocr Rev. 2001;22(4):477–501. Review.
Holick MF. Vitamin D. The underappreciated D-lightful hormone that is important for skeletal and cellular health. Curr Opin Endocrinol Diabetes 2002;9:87–98.
Chiu KC, Chu A, Go VL, Saad MF. Hypovitaminosis D is associated with insulin resistance and beta cell dysfunction. Am J Clin Nutr. 2004;79(5):820–5.
Lind L, Hanni A, Lithell H, Hvarfner A, Sorensen OH, Ljunghall S. Vitamin D is related to blood pressure and other cardiovascular risk factors in middle-aged men. Am J Hypertens. 1995; 8(9):894–901.
Boucher BJ, Mannan N, Noonan K, Hales CN, Evans SJ. Glucose intolerance and impairment of insulin secretion in relation to vitamin D deficiency in east London Asians. Diabetologia. 1995;38(10):1239–45.
Gedik O, Akalin S. Effects of vitamin D deficiency and repletion on insulin and glucagon secretion in man. Diabetologia. 1986;29(3):142–5.
Trivedi DP, Doll R, Khaw KT. Effect of four monthly oral vitamin D3 (cholecalciferol) supplementation on fractures and mortality in men and women living in the community: randomised double blind controlled trial. BMJ. 2003; 326(7387):469–72.
Malabanan A, Veronikis IE, Holick MF. Redefining vitamin D insufficiency. Lancet. 1998;351(9105):805–6.
Bischoff-Ferrari HA, Dawson-Hughes B, Willett WC, et al. Effect of Vitamin D on falls: a meta-analysis. JAMA. 2004;291(16):1999–2006. Review.
Fiscella K. Is lower income associated with greater biopsychosocial morbidity? Implications for physicians working with underserved patients. J Fam Pract. 1999;48(5):372–7.
Reed MC, Tu HT. Triple jeopardy: low income, chronically ill and uninsured in America. Issue Brief Cent Stud Health Syst Change. 2002;(49):1–4.
Uninsured Americans with Chronic Health Conditions: Key Findings from the National Health Interview Survey. Available at: http://www.urban.org/UploadedPDF/411161_uninsured_americans.pdf.
The 2007 HHS Poverty Guidelines. Available at: http://aspe.hhs.gov/poverty/07poverty.shtml.
Holick MF, Siris ES, Binkley N, et al. Prevalence of vitamin D inadequacy among postmenopausal north American woman receiving osteoporosis therapy. J Clin Endocrinol Metab. 2005;90(6):3215–24.
Blalock SJ, Norton LL, Patel RA, Cabral K, Thomas CL. Development and assessment of a short instrument for assessing dietary intakes of calcium and vitamin D. J Am Pharm Assoc (Wash DC). 2003;43(6):685–93.
Kauppinen-Makelin R, Tahtela R, Loyttyniemi E, Karkkainen J, Valimaki MJ. A high prevalence of hypovitaminosis D in Finnish medical in- and outpatients. J Intern Med. 2001; 249(6):559–63.
Lips P, Duong T, Oleksik A, Black, et al. A global study of vitamin D status and parathyroid function in postmenopausal women with osteoporosis: baseline data from the multiple outcomes of raloxifene evaluation clinical trial. J Clin Endocrinol Metab. 2001;86(3):1212–21.
Harris SS, Soteriades E, Dawson-Hughes B. Secondary hyperparathyroidism and bone turnover in elderly blacks and whites. J Clin Endocrinol Metab. 2001;86:3801–3804
Dawson-Hughes B, Heaney RP, Holick MF, Lips P, Meunier PJ, Vieth R. Estimates of optimal vitamin D status. Osteoporosis Int. 2005;16:713–6.
Harris SS, Dawson-Hughes B. Seasonal changes in plasma 25hydroxyvitamin D concentrations of young American black and white women. Am J Clin Nutr. 1998;67(6):1232–6.
Looker AC, Dawson-Hughes B, Calvo MS, Gunter EW, Sahyoun NR. Serum 25-hydroxyvitamin D status of adolescents and adults in two seasonal subpopulations from NHANES III. Bone. 2002;30(5):771–7.
Moore CE, Murphy MM, Holick MF. Vitamin D intakes by children and adults in the United States differ among ethnic groups. J Nutr 2005;135:2478–85
Acknowledgment
We would like to thank Dr. Susan Blalock for granting us permission to use the food questionnaire, Dr. Mindy Smith and Dr. Carole Keefe for their mentorship, Dr. Brenda Gillespie for her expert statistical review and the staff at Genesee County free medical clinic for all their support during this study. This article was presented at the Flint Area Medical Education (FAME) research meeting, May 2005, ACP Michigan Associates Meeting, May 2005 and ACP Michigan Chapter meeting, Sept. 2005)
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Kakarala, R.R., Chandana, S.R., Harris, S.S. et al. Prevalence of Vitamin D Deficiency in Uninsured Women. J GEN INTERN MED 22, 1180–1183 (2007). https://doi.org/10.1007/s11606-007-0245-x
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DOI: https://doi.org/10.1007/s11606-007-0245-x