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Clinical efficacy and value of redistributed subclavian arterial infusion chemotherapy for locally advanced breast cancer

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Abstract

Purpose

The aim of this study was to evaluate the efficacy and safety of redistributed subclavian arterial infusion chemotherapy (RESAIC). We have focused on the local response, quality of life (QOL), and complications. We have also investigated factors that influence the local response of RESAIC.

Materials and methods

The subjects were patients with locally advanced breast cancer whose tumors were resistant to standard systemic chemotherapy (at least more than two regimens), those who were physically unable to tolerate systemic chemotherapy, and patients with locally recurrent breast cancer. The registration period was between April 2006 and May 2009.

Results

A total of 24 cases in 22 patients (mean age 59.5 years, range 36–82 years) were entered in the study. The local response rate of RESAIC was 77.3% (17/22). The QOL score showed improvement on average. There were no serious complications during catheter port implantation, and there was hematological toxicity over grade 3 in 27.3% (6/22) of patients. A significant difference between responders and nonresponders was seen in patients with a replaced type tumor (on imaging, diffuse contrast enhancement was seen in whole quadrants) (P = 0.043), and the patients underwent radiotherapy (P = 0.043).

Conclusion

RESAIC is an effective, safe treatment for locally advanced breast cancer. Because it was reviewed in only a few cases, however, large-scale studies are warranted.

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Authors and Affiliations

  1. Department of Radiology, St. Marianna University School of Medicine, 2-16-1 Sugao, Miyamae-ku, Kawasaki, 216-8511, Japan

    Hiroshi Shimamoto, Kenji Takizawa, Yukihisa Ogawa, Misako Yoshimatsu, Kunihiro Yagihashi, Hiroko Okazaki, Yoshihide Kanemaki & Yasuo Nakajima

  2. Department of Breast and Endocrine Surgery, St. Marianna University School of Medicine, Kawasaki, Japan

    Tomohiko Ohta & Haruki Ogata

  3. Breast & Imaging Center, St. Marianna University School of Medicine, Kawasaki, Japan

    Mamoru Fukuda

Authors
  1. Hiroshi Shimamoto
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  2. Kenji Takizawa
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  3. Yukihisa Ogawa
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  4. Misako Yoshimatsu
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  5. Kunihiro Yagihashi
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  9. Tomohiko Ohta
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  11. Mamoru Fukuda
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Corresponding author

Correspondence to Hiroshi Shimamoto.

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Shimamoto, H., Takizawa, K., Ogawa, Y. et al. Clinical efficacy and value of redistributed subclavian arterial infusion chemotherapy for locally advanced breast cancer. Jpn J Radiol 29, 236–243 (2011). https://doi.org/10.1007/s11604-010-0547-5

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  • DOI: https://doi.org/10.1007/s11604-010-0547-5

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