Abstract
Purpose
We conducted statistical parametric comparison of fractional anisotropy (FA) images and quantified FA values to determine whether significant change occurs in the ischemic region.
Materials and methods
The subjects were 20 patients seen within 24 h after onset of ischemia. For statistical comparison of FA images, a sample FA image was coordinated by the Talairach template, and each FA map was normalized. Statistical comparison was conducted using SPM99. Regions of interest were set in the same region on apparent diffusion coefficient (ADC) and FA maps, the region being consistent with the hyperintense region on diffusion-weighted images (DWIs). The contralateral region was also measured to obtain asymmetry ratios of ADC and FA.
Results
Regions with areas of statistical significance on FA images were found only in the white matter of three patients, although the regions were smaller than hyperintense regions on DWIs. The mean ADC and FA ratios were 0.64 ± 0.16 and 0.93 ± 0.09, respectively, and the degree of FA change was less than that of the ADC change. Significant change in diffusion anisotropy was limited to the severely infarcted core of the white matter.
Conclusion
We believe statistical comparison of FA maps to be useful for detecting different regions of diffusion anisotropy.
Similar content being viewed by others
References
SE Maier H Gudbjartsson L Hsu FA Jolesz (1997) ArticleTitleDiffusion anisotropy imaging of stroke Proc Int Soc Magn Reson 573 4
PA Armitage ME Bastin I Marshall JM Wardlan J Cannon (1998) ArticleTitleDiffusion anisotropy measurements in ischaemic stroke of the human brain MAGMA 6 28–36 Occurrence Handle9794287 Occurrence Handle1:STN:280:DyaK1M%2FgvVCiug%3D%3D
O Wu PE Grant WJ Koroshetz (2000) ArticleTitleReversal of DWI lesions may be associated with increases in anisotropy Proc Int Soc Magn Reson Med 778 8
F Zelaya N Flood JB Chalk D Wang DM Doddrell W Strugnell et al. (1999) ArticleTitleAn evaluation of the time dependence of the anisotropy of the water diffusion tensor in acute human stroke Magn Reson Imag 17 331–48 Occurrence Handle1:STN:280:DyaK1M3gvF2msw%3D%3D Occurrence Handle10.1016/S0730-725X(98)00192-1
Q Yang BM Tress PA Barber PM Desmond DG Daarby RP Gerraty et al. (1999) ArticleTitleSerial study of apparent diffusion coefficient and anisotropy in patients with acute stroke Stroke 30 2382–90 Occurrence Handle10548675 Occurrence Handle1:STN:280:DC%2BD3c%2FhvVelsg%3D%3D
AG Sorensen O Wu WA Copen TL Davis RG Gonzalez Koroshetz et al. (1999) ArticleTitleHuman acute cerebral ischemia: detection of changes in water diffusion anisotropy by using MR imaging Radiology 212 785–92 Occurrence Handle10478247 Occurrence Handle1:STN:280:DyaK1MvgslKrtw%3D%3D
P van Gelderen MHM De Vleeschouwer D DesPres J Pekar PCM Van Zijl CTW Moonen (1994) ArticleTitleWater diffusion in acute stroke Magn Reson Med 31 154–63 Occurrence Handle8133751 Occurrence Handle1:STN:280:ByuC1c%2FnsVM%3D
RA Carano F Li K Irie KG Helmer MD Silva M Fisher et al. (2000) ArticleTitleMultispectral analysis of the temporal evolution of cerebral ischemia in the rat brain J Magn Reson Imag 12 842–58 Occurrence Handle1:STN:280:DC%2BD3M7htVarsw%3D%3D Occurrence Handle10.1002/1522-2586(200012)12:6<842::AID-JMRI7>3.0.CO;2-5
RAD Carano F Li K Irie M Fisher CH Sotak (1998) ArticleTitleThe temporal evolution of diffusion anisotropy in the ischemic rat brain Proc Int Soc Magn Reson Med 5 530
C Pierpaoli PJ Basser (1996) ArticleTitleToward a quantitative assessment of diffusion anisotropy Magn Reson Med 36 893–906 Occurrence Handle8946355 Occurrence Handle1:STN:280:ByiC3c7otlM%3D
DJ Werring AT Toosy CA Clark GJ Parker GJ Barker DH Miller et al. (2000) ArticleTitleDiffusion tensor imaging can detect and quantify corticospinal tract generation after stroke J Neurol Neurosurg Psychiatry 69 269–72 Occurrence Handle10896709 Occurrence Handle1:STN:280:DC%2BD3cvgsFCltw%3D%3D Occurrence Handle10.1136/jnnp.69.2.269
SH Eriksson FJ Rugg-Gunn MR Symms GJ Barker JS Duncan (2001) ArticleTitleDiffusion tensor imaging in patients with epilepsy and malformations of cortical development Brain 124 617–26 Occurrence Handle11222460 Occurrence Handle1:STN:280:DC%2BD3M7ps1Cgsg%3D%3D Occurrence Handle10.1093/brain/124.3.617
FJ Rugg-Gunn SH Eriksson MR Symms GJ Barker JS Duncan (2001) ArticleTitleDiffusion tensor imaging of cryptogenic and acquired partial epilepsies Brain 124 627–36 Occurrence Handle11222461 Occurrence Handle1:STN:280:DC%2BD3M7ps1Cgsw%3D%3D Occurrence Handle10.1093/brain/124.3.627
CK Kuhl J Textor J Gieseke M von Falkenhausen S Gernert C Sonntag et al. (2005) ArticleTitleAcute and subacute ischemic stroke at high-field-strength (3.0-T) diffusion-weighted MR imaging: intraindividual comparative study Radiology 234 509–16 Occurrence Handle15601894
Author information
Authors and Affiliations
Corresponding author
Additional information
This article was presented at a Japan Radiological Society meeting in April 2005
About this article
Cite this article
Morita, N., Harada, M., Uno, M. et al. Change of diffusion anisotropy in patients with acute cerebral infarction using statistical parametric analysis. Radiat Med 24, 253–259 (2006). https://doi.org/10.1007/s11604-005-1535-z
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/s11604-005-1535-z