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Immunomodulation of Proton-activated G Protein-coupled Receptors in Inflammation

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Abstract

Proton-activated G protein-coupled receptors (GPCRs), initially discovered by Ludwig in 2003, are widely distributed in various tissues. These receptors have been found to modulate the immune system in several inflammatory diseases, including inflammatory bowel disease, atopic dermatitis, and asthma. Proton-activated GPCRs belong to the G protein-coupled receptor family and can detect alternations in extracellular pH. This detection triggers downstream signaling pathways within the cells, ultimately influencing the function of immune cells. In this review, we specifically focused on investigating the immune response of proton-activated GPCRs under inflammatory conditions.

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Authors and Affiliations

  1. Department of Otolaryngology-Head and Neck Surgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China

    Min-shan Li, Xiang-hong Wang & Heng Wang

  2. Institute of Allergy and Clinical Immunology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China

    Min-shan Li, Xiang-hong Wang & Heng Wang

  3. Hubei Clinical Research Center for Nasal Inflammatory Diseases, Wuhan, 430030, China

    Min-shan Li, Xiang-hong Wang & Heng Wang

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  1. Min-shan Li
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  2. Xiang-hong Wang
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  3. Heng Wang
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Correspondence to Heng Wang.

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This study was supported by the National Nature Science Foundation of China (No. 81873694), the Key Research and Development Program of Hubei Province (No. 2022BCA005), and Knowledge Innovation Program of Wuhan Basic Research (No. 2022020801010446).

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Li, Ms., Wang, Xh. & Wang, H. Immunomodulation of Proton-activated G Protein-coupled Receptors in Inflammation. CURR MED SCI (2024). https://doi.org/10.1007/s11596-024-2872-4

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