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Prognostic Value of ALP and LDH in Periampullary Carcinoma Patients Undergoing Surgery

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Abstract

Objective

Conversion of normal cells to cancer cells is often accompanied by abnormal synthesis of serum enzymes. Both alkaline phosphatase (ALP) and lactate dehydrogenase (LDH) have been reported to have prognostic value in a variety of malignancies. The aim of this study was to investigate the effect of preoperative serum ALP and LDH levels on the prognosis of patients with periampullary carcinoma who underwent pancreatoduodenectomy (PD).

Methods

According to the preoperative ALP or LDH values, 856 cancer patients receiving PD treatment from January 2001 to January 2019 were divided into high-ALP group and low-ALP group or high-LDH group and low-LDH group. Statistical analysis was carried out to study the differences between the high-ALP and low-ALP groups or the high-LDH and low-LDH groups. Furthermore, the possibility of preoperative ALP or LDH as prognostic factor of periampullary carcinoma was investigated.

Results

In both the high-ALP and the high-LDH groups, the prognosis of patients with periampullary carcinoma who underwent PD was worse than that of the low-ALP and low- LDH group. Even through risk factor analysis, it was found that preoperative ALP and LDH could be independent prognostic factor for patients with periampullary carcinoma who underwent PD.

Conclusion

Preoperative ALP or LDH is an independent risk factor for periampullary carcinoma.

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Authors and Affiliations

  1. Department of Pancreatic-Biliary Surgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China

    Chao Dang & Ren-yi Qin

  2. Department of Dermatology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China

    Yun-hua Deng

Authors
  1. Chao Dang
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  2. Yun-hua Deng
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  3. Ren-yi Qin
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Corresponding authors

Correspondence to Yun-hua Deng or Ren-yi Qin.

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The authors declare that there is no conflict of interest regarding the publication of this article.

Additional information

This study was supported by the National Natural Science Foundation of China (No. 81772950).

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Dang, C., Deng, Yh. & Qin, Ry. Prognostic Value of ALP and LDH in Periampullary Carcinoma Patients Undergoing Surgery. CURR MED SCI 42, 150–158 (2022). https://doi.org/10.1007/s11596-021-2452-9

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  • DOI: https://doi.org/10.1007/s11596-021-2452-9

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