Summary
The expression of Survivin, CDK4 and Ki-67 and the clinical significance in pediatric acute leukemia (AL) were investigated. The expression of Survivin, CDK4 and Ki-67 proteins was detected by using immunohistochemical assay in 37 children with AL and 10 children with normal bone marrow as controls. The positive expression rate of Survivin, CDK4 and Ki-67 was 45.9 %, 56.8 %, and 40.5 % respectively in 37 AL children, which was significantly higher than in control group accordingly (P<0.05). The expression of Survivin was positively correlated with CDK4 (P=0.007) and Ki-67 (P=0.008). In conclusion, all Survivin, CDK4 and Ki-67 proteins are over-expressed in pediatric AL and involved in the modulation of apoptosis and proliferation in pediatric AL.
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Zhang, L., Liu, J., Lin, H. et al. Expression of survivin, CDK4, Ki-67 and clinical significance in pediatric acute leukemia. J. Huazhong Univ. Sc. Technol. 26, 552–554 (2006). https://doi.org/10.1007/s11596-006-0517-4
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DOI: https://doi.org/10.1007/s11596-006-0517-4