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Ionic liquid/multiwall carbon nanotubes paste electrode for square wave voltammetric determination of methyldopa

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Abstract

Ionic liquid/multiwall carbon nanotubes paste electrode has been used as a novel sensor for the efficient quantitative determination of methyldopa (MDOP) in pharmaceutical and biological samples by using square wave voltammetry. This new sensor shows a better electrochemical response with lower over-potential and high sensitivity for MDOP compared with unmodified carbon paste electrode in physiological condition. The electro-oxidation of MDOP occurred in a pH-dependent 2e− and 2H+ process, and the electrode reaction followed a diffusion-controlled pathway. Under the optimum conditions, the voltammetric oxidation peak current of MDOP showed two linear dynamic ranges with a detection limit of 0.1 μM for MDOP. The novel sensor has been found selective and successfully implemented for the determination of MDOP in real samples such as tablet and patient urine.

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Acknowledgments

The authors gratefully acknowledge Islamic Azad University, Falavarjan Branch research council, and National Foundation for Iranian Elites for their support of this work.

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Authors and Affiliations

  1. Department of Biochemistry, Falavarjan Branch, Islamic Azad University, Falavarjan, Iran

    Masoud Fouladgar

  2. Department of Chemistry, Science and Research Branch, Islamic Azad University, Mazandaran, Iran

    Hassan Karimi-Maleh

Authors
  1. Masoud Fouladgar
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  2. Hassan Karimi-Maleh
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Corresponding authors

Correspondence to Masoud Fouladgar or Hassan Karimi-Maleh.

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Fouladgar, M., Karimi-Maleh, H. Ionic liquid/multiwall carbon nanotubes paste electrode for square wave voltammetric determination of methyldopa. Ionics 19, 1163–1170 (2013). https://doi.org/10.1007/s11581-012-0832-7

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  • DOI: https://doi.org/10.1007/s11581-012-0832-7

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