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PHIL® (precipitating hydrophobic injectable liquid): retrospective multicenter experience on 178 patients in peripheral embolizations

  • Vascular and Interventional Radiology
  • Published:
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Abstract

Purpose

This study aims to analyze safety and effectiveness of PHIL® (Microvention, CA-USA) in peripheral endovascular embolization procedures, both in elective and emergent scenarios.

Materials and Methods

This is a multicenter retrospective study, involving 178 patients from five interventional radiology departments from January 2017 to December 2021. Patients treated by an endovascular embolization with PHIL® were included; different PHIL® viscosities were adopted. Exclusion criteria were: neuroradiological endovascular interventions, other cohesive liquid embolics adopted during the same procedure, follow-up < 30 days. Technical success was intended as definitive target vessel occlusion without the need for other embolics after PHIL® injection. Clinical success was considered as restoration of hemodynamic status in case of emergent embolization and improvement of clinical conditions in case of elective procedures, without additional interventions at 30 days.

Results

Sixty-four women and 114 men, mean age 62 years (range 6–91), were evaluated. Sixty-three patients were in elective scenarios (AVMs, type-II endoleaks, tumors, varices, aneurysms, varicoceles) and 115 were in emergent settings (hemorrhage, pseudoaneurysms, hemoptysis, priapism); 190 procedures were performed in 178 patients. Overall technical and clinical success rates were 94.7% and 92.1%, respectively. The complications rate was 7.4% (6 grade-I, 7 grade-III, 1 grade-IV). PHIL®-25 was the more adopted viscosity; totally, 311 vials were injected (rate: 1.64 vial/procedure).

Conclusion

In this series, PHIL® proved to be a safe and effective liquid embolic in peripheral embolizations, both in elective and emergent scenarios. The pre-filled syringe preparation allowed operators to use it even when unplanned at beginning of the intervention.

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Funding

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Authors and Affiliations

  1. Vascular and Interventional Radiology Department, Cardarelli Hospital, Via Antonio Cardarelli 9, 80131, Naples, Italy

    Francesco Giurazza, Fabio Corvino & Raffaella Niola

  2. Unit of Interventional Radiology, IRCSS Policlinico San Matteo Foundation, Viale Camillo Golgi 19, 27100, Pavia, Italy

    Nicola Cionfoli & Pietro Quaretti

  3. Radiology and Neuroradiology Department, Ospedale SS. Annunziata, Via F. Bruno 1, 74121, Taranto, Italy

    Andrea Paladini

  4. Radiology Department, Ospedale Civico Di Cristina e Benfratelli, Piazza Leotta Nicola 4, 90127, Palermo, Italy

    Mario Vallone

  5. Interventional Radiology Section of Department of Radiological, Oncological, and Anatomopathological, Sciences of Policlinico Umberto I of Rome, Sapienza University of Rome, 00161, Rome, Italy

    Leonardo Teodoli, Carlo Catalano & Pierleone Lucatelli

  6. Unit of Radiology and Interventional Radiology, Sant’Anna Hospital, Via Ravona, 22042, Como, Italy

    Lorenzo Moramarco

Authors
  1. Francesco Giurazza
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  2. Nicola Cionfoli
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  3. Andrea Paladini
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  4. Mario Vallone
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  5. Fabio Corvino
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  6. Leonardo Teodoli
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  7. Lorenzo Moramarco
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  8. Pietro Quaretti
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  9. Carlo Catalano
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  10. Raffaella Niola
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  11. Pierleone Lucatelli
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Corresponding author

Correspondence to Francesco Giurazza.

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The authors declare that they have no conflict of interest.

Ethical standards

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and national research committee and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards.

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Informed consent to study participation was waived due to the retrospective design.

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Giurazza, F., Cionfoli, N., Paladini, A. et al. PHIL® (precipitating hydrophobic injectable liquid): retrospective multicenter experience on 178 patients in peripheral embolizations. Radiol med 127, 1303–1312 (2022). https://doi.org/10.1007/s11547-022-01552-y

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  • DOI: https://doi.org/10.1007/s11547-022-01552-y

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