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Magnetic resonance elastography for evaluation of renal parenchyma in chronic kidney disease: a pilot study

  • ABDOMINAL RADIOLOGY
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Abstract

Objective

This study aimed to prospectively evaluate the difference in renal parenchymal stiffness, measured using MR elastography, between patients with chronic kidney disease (CKD) and healthy volunteers. In addition, differences in stiffness values were assessed among the five stages of CKD.

Materials and methods

Five healthy volunteers and 25 patients with CKD (five patients in each stage) were enrolled in the study. Each patient was positioned prone in a 3-T MR scanner and imaged with an abdominal 64-channel surface coil. Calculated tissue stiffness values were compared with the corresponding stage of CKD.

Results

The mean stiffnesses in normal healthy volunteers and patients with CKD (regardless of stage) were 4.35 kPa and 5.10 kPa, respectively (p = 0.027). The mean stiffness in patients with CKD significantly increased with the CKD stage (p = 0.013), although it decreased in stage 5 CKD.

Conclusion

Renal tissue stiffness measured using MR elastography can be used to distinguish between patients with CKD and healthy individuals; moreover, it can be useful in predicting the stage of CKD.

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References

  1. Hewitson TD (2009) Renal tubulointerstitial fibrosis: common but never simple. Am J Physiol Renal Physiol 296:1239–1244

    Article  Google Scholar 

  2. Perkins BA, Nelson RG, Ostrander BE, Blouch KL, Krolewski AS, Myers BD et al (2005) Detection of renal function decline in patients with diabetes and normal or elevated GFR by serial measurements of serum cystatin C concentration: results of a 4-year follow-up study. J Am Soc Nephrol 16:1404–1414

    Article  Google Scholar 

  3. Kiberd BA, Clase CM (2002) Cumulative risk for developing end-stage renal disease in the US population. J Am Soc Nephrol 13:1635–1644

    Article  Google Scholar 

  4. Prigent A (2008) Monitoring renal function and limitations of renal function tests. In: Bouchelouche K, Sathekge MM (eds) Seminars in nuclear medicine. WB Saunders, vol 38, pp 32–46

  5. Yalçin-Şafak K, Ayyildiz M, Ünel SY, Umarusman-Tanju N, Akça A, Baysal T (2016) The relationship of ADC values of renal parenchyma with stage of CKD and serum creatinine levels. Eur J Radiol Open 3:8–11

    Article  Google Scholar 

  6. Lee CU, Glockner JF, Glaser KJ, Yin M, Chen J, Kawashima A et al (2012) MR elastography in renal transplant patients and correlation with renal allograft biopsy: a feasibility study. Acad Radiol 19:834–841

    Article  Google Scholar 

  7. National Kidney Foundation (2002) K/DOQI clinical practice guidelines for chronic kidney disease: evaluation, classification, and stratification. Am J Kidney Dis 39:S1–266

    Google Scholar 

  8. Official Publication of the Japan Society of Nephrology (2009) Evaluation method for kidney function and urinary findings. Clin Exp Nephrol 13:209–211

    Article  Google Scholar 

  9. Manduca A, Oliphant TE, Dresner MA, Mahowald JL, Kruse SA, Amromin E et al (2001) Magnetic resonance elastography: non-invasive mapping of tissue elasticity. Med Image Anal 5:237–254

    Article  CAS  Google Scholar 

  10. Thoeny HC, De Keyzer F, Oyen RH, Peeters RR (2005) Diffusion-weighted MR imaging of kidneys in healthy volunteers and patients with parenchymal diseases-initial experience. Radiology 235:911–917

    Article  Google Scholar 

  11. Guo LH, Xu HX, Fu HJ, Peng A, Zhang YF, Liu LN (2013) Acoustic radiation force impulse imaging for noninvasive evaluation of renal parenchyma elasticity: preliminary findings. PLoS ONE. https://doi.org/10.1371/journal.pone.0068925

    Article  PubMed  PubMed Central  Google Scholar 

  12. Menzilcioglu MS, Duymus M, Citil S, Avcu S, Gungor G, Sahin T et al (2015) Strain wave elastography for evaluation of renal parenchyma in chronic kidney disease. Br J Radiol. https://doi.org/10.1259/bjr.20140714

    Article  PubMed  PubMed Central  Google Scholar 

  13. Wang L, Xia P, Lv K, Han J, Dai Q, Li XM et al (2014) Assessment of renal tissue elasticity by acoustic radiation force impulse quantification with histopathological correlation: preliminary experience in chronic kidney disease. Eur Radiol 24:1694–1699

    Article  Google Scholar 

  14. Guo Y, Parthasarathy S, Goyal P, McCarthy RJ, Larson AC, Miller FH (2015) Magnetic resonance elastography and acoustic radiation force impulse for staging hepatic fibrosis: a meta-analysis. Abdom Imaging 40:818–834

    Article  Google Scholar 

  15. Morrell GR, Zhang JL, Lee VS (2017) Magnetic resonance imaging of the fibrotic kidney. J Am Soc Nephrol 28:2564–2570

    Article  CAS  Google Scholar 

  16. Xu Y, Wang X, Jiang X (2007) Relationship between the renal apparent diffusion coefficient and glomerular filtration rate: preliminary experience. J Magn Reson Imaging 26:678–681

    Article  Google Scholar 

  17. Xu X, Fang W, Ling H, Chai W, Chen K (2010) Diffusion-weighted MR imaging of kidneys in patients with chronic kidney disease: initial study. Eur Radiol 20:978–983

    Article  Google Scholar 

  18. Toya R, Naganawa S, Kawai H, Ikeda M (2010) Correlation between estimated glomerular filtration rate (eGFR) and apparent diffusion coefficient (ADC) values of the kidneys. Magn Reson Med Sci 9:59–64

    Article  Google Scholar 

  19. Hu Q, Wang XY, He HG, Wei HM, Kang LK, Qin GC (2014) Acoustic radiation force impulse imaging for non-invasive assessment of renal histopathology in chronic kidney disease. PLoS ONE. https://doi.org/10.1371/journal.pone.0115051

    Article  PubMed  PubMed Central  Google Scholar 

  20. Yoon JH, Lee JM, Joo I, Lee ES, Sohn JY, Jang SK et al (2014) Hepatic fibrosis: prospective comparison of MR elastography and US shear-wave elastography for evaluation. Radiology 273:772–782

    Article  Google Scholar 

  21. Ichikawa S, Motosugi U, Morisaka H, Sano K, Ichikawa T, Tatsumi A et al (2015) Comparison of the diagnostic accuracies of magnetic resonance elastography and transient elastography for hepatic fibrosis. Magn Reson Imaging 33:26–30

    Article  Google Scholar 

  22. Rouvière O, Souchon R, Pagnoux G, Ménager JM, Chapelon JY (2011) Magnetic resonance elastography of the kidneys: feasibility and reproducibility in young healthy adults. J Magn Reson Imaging 34:880–886

    Article  Google Scholar 

  23. Low G, Owen NE, Joubert I, Patterson AJ, Graves MJ, Glaser KJ et al (2015) Reliability of magnetic resonance elastography using multislice two-dimensional spin-echo echo-planar imaging (SE-EPI) and three-dimensional inversion reconstruction for assessing renal stiffness. J Magn Reson Imaging 42:844–850

    Article  Google Scholar 

  24. Marticorena Garcia SR, Grossmann M, Lang ST, Tzschätzsch H, Dittmann F, Hamm B et al (2018) Tomoelastography of the native kidney: regional variation and physiological effects on in vivo renal stiffness. Magn Reson Med 79:2126–2134

    Article  Google Scholar 

  25. Kline TL, Edwards ME, Garg I, Irazabal MV, Korfiatis P, Harris PC et al (2018) Quantitative MRI of kidneys in renal disease. Abdom Radiol 43:629–638

    Article  Google Scholar 

  26. Kim D, Kim WR, Talwalkar JA, Kim HJ, Ehman RL (2013) Advanced fibrosis in nonalcoholic fatty liver disease: noninvasive assessment with MR elastography. Radiology 268:411–419

    Article  Google Scholar 

  27. Wang Y, Ganger DR, Levitsky J, Sternick LA, McCarthy RJ, Chen ZE et al (2011) Assessment of chronic hepatitis and fibrosis: comparison of MR elastography and diffusion-weighted imaging. AJR Am J Roentgenol 196:553–561

    Article  Google Scholar 

  28. Venkatesh SK, Wang G, Lim SG, Wee A (2014) Magnetic resonance elastography for the detection and staging of liver fibrosis in chronic hepatitis B. Eur Radiol 24:70–78

    Article  Google Scholar 

  29. Chang W, Lee JM, Yoon JH, Han JK, Choi BI, Yoon JH et al (2016) Liver fibrosis staging with MR elastography: comparison of diagnostic performance between patients with chronic hepatitis B and those with other etiologic causes. Radiology 280:88–97

    Article  Google Scholar 

  30. Hoodeshenas S, Yin M, Venkatesh SK (2018) Magnetic resonance elastography of liver-current update. Top Magn Reson Imaging 27:319–333

    Article  Google Scholar 

  31. Warner L, Yin M, Glaser KJ, Woollard JA, Carrascal CA, Korsmo MJ et al (2011) Noninvasive In vivo assessment of renal tissue elasticity during graded renal ischemia using MR elastography. Invest Radiol 46:509–514

    Article  Google Scholar 

  32. Venkatesh SK, Ehman RL (2015) Magnetic resonance elastography of abdomen. Abdom Imaging 40:745–759

    Article  Google Scholar 

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Authors and Affiliations

  1. Department of Radiology, Yonsei University Wonju College of Medicine, Wonju Severance Christian Hospital, 20 Ilsan-ro, Wonju, Gangwon-do, 26426, Republic of Korea

    Jun Hee Han & Jhii-Hyun Ahn

  2. Department of Internal Medicine, Yonsei University Wonju College of Medicine, Wonju Severance Christian Hospital, 20 Ilsan-ro, Wonju, Gangwon-do, 26426, Republic of Korea

    Jae-Seok Kim

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  1. Jun Hee Han
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  2. Jhii-Hyun Ahn
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Correspondence to Jhii-Hyun Ahn.

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The authors declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.

Ethical standards

The present study was conducted in accordance with the institutional ethical committee of Wonju Severance Christian Hospital.

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Patient informed consent was obtained at the time of study enrollment.

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Han, J.H., Ahn, JH. & Kim, JS. Magnetic resonance elastography for evaluation of renal parenchyma in chronic kidney disease: a pilot study. Radiol med 125, 1209–1215 (2020). https://doi.org/10.1007/s11547-020-01210-1

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  • DOI: https://doi.org/10.1007/s11547-020-01210-1

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