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Analysis of magnetic resonance imaging findings of children with neurologic complications after liver transplantation

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Abstract

Objective

To analyze the magnetic resonance imaging findings in children diagnosed with neurologic complications after liver transplantation (LT).

Materials and methods

A total of 39 patients diagnosed with neurologic complications following LT between 2010 and 2016. Neuroradiologic imaging was performed using cranial magnetic resonance imaging (MRI). Descriptive statistics regarding age, gender, type of complication, diagnostic and therapeutic modalities were calculated and presented as number and percentage.

Results

Our series consisted of 18 girls and 21 boys. Cryptogenic hepatitis (n = 13, 32%), metabolic diseases (Wilson’s disease, tyrosinemia and glycogen storage disease) (n = 7, 18%) and fulminant toxic hepatitis (n = 4, 11%) constitute the most frequent indications for LT. The indications for neuroradiological imaging were convulsion and alteration of mental status.

Conclusion

These central nervous system complications may present in a variable spectrum and convulsions and altered mental state were the most frequent clinical pictures. Imaging studies were normal in approximately one-third of cases; the most frequent pathologic findings were diffuse cerebral edema, atrophy, and PRES. Clinical history, careful examination and integrated analysis of radiologic data as well as close collaboration and multidisciplinary approach are of utmost importance for establishing the diagnosis rapidly and accurately.

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Acknowledgements

None of the authors involved in this study received financial support.

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Authors and Affiliations

  1. Department of Pediatric Radiology, Diyarbakır Children’s Hospital, 21100, Diyarbakir, Turkey

    Mehmet Öztürk

  2. Department of Pediatric Radiology, Inonu University School of Medicine, 44100, Malatya, Turkey

    İsmail Akdulum, Nurullah Dağ & Ahmet Sığırcı

  3. Department of Pediatric Neurology, Inonu University School of Medicine, 44100, Malatya, Turkey

    Serdal Güngör

  4. Department of General Surgery, Inonu University School of Medicine, 44100, Malatya, Turkey

    Sezai Yılmaz

Authors
  1. Mehmet Öztürk
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  2. İsmail Akdulum
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  3. Nurullah Dağ
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  4. Ahmet Sığırcı
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  5. Serdal Güngör
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  6. Sezai Yılmaz
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Corresponding author

Correspondence to Mehmet Öztürk.

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All authors declare that they have no conflict of interest.

Ethical approval

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

Informed consent

Informed consent was obtained from all individual participants included in the study.

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Öztürk, M., Akdulum, İ., Dağ, N. et al. Analysis of magnetic resonance imaging findings of children with neurologic complications after liver transplantation. Radiol med 122, 617–622 (2017). https://doi.org/10.1007/s11547-017-0756-4

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  • DOI: https://doi.org/10.1007/s11547-017-0756-4

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