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Screening for lung cancer using low-dose spiral CT: 10 years later, state of the art

Lo screening del tumore polmonare mediante TC spirale a bassa dose: dieci anni dopo, lo stato dell’arte

  • Chest Radiology / Radiologia Toracica
  • Published:
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Abstract

Ten years after the first papers on this subject, this editorial represents a brief review on lung cancer screening with low-dose spiral CT. The aim is to present the main theoretical and practical problems related to lung cancer screening, the historical background and results of observational studies and the main ongoing randomised controlled trials. In particular, the National Lung Screening Trial (NLST), which was interrupted early, is discussed. The opinion of the authors is that too many questions are still awaiting an answer.

Riassunto

A dieci anni dai primi lavori sull’argomento, questo editoriale fa il punto della situazione sullo screening del tumore polmonare mediante tomografia computerizzata (TC) a bassa dose. Vengono esposti i principali problemi teorici e pratici connessi alla screening oncologico per il tumore polmonare, le premesse storiche, i risultati degli studi osservazionali ed i principali trial randomizzati e controllati in corso. In particolare, viene trattato in dettaglio lo studio National Lung Screening Trial (NLST), che è stato concluso con anticipo. Vengono esposti i risultati, insieme alle molte questioni ancora irrisolte e alle domande che attendono una risposta.

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Authors and Affiliations

  1. Sezione di Radiologia, Dipartimento di Scienze Radiologiche e Istocitopatologiche, Università di Bologna, Bologna, Italy

    M. Zompatori & F. Ciccarese

  2. Sezione di Radiodiagnostica, Dipartimento di Fisiopatologia Clinica, Università di Firenze, Firenze, Italy

    M. Mascalchi

  3. Sezione di Radiodiagnostica, Dipartimento di Scienze Cliniche, Università di Parma, Parma, Italy

    N. Sverzellati

  4. Chirurgia Toracica, Istituto Nazionale Tumori, Milano, Italy

    U. Pastorino

Authors
  1. M. Zompatori
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  2. M. Mascalchi
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  3. F. Ciccarese
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  4. N. Sverzellati
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  5. U. Pastorino
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Correspondence to M. Zompatori.

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Zompatori, M., Mascalchi, M., Ciccarese, F. et al. Screening for lung cancer using low-dose spiral CT: 10 years later, state of the art. Radiol med 118, 51–61 (2013). https://doi.org/10.1007/s11547-012-0843-5

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  • DOI: https://doi.org/10.1007/s11547-012-0843-5

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