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Computer simulation-based nanothermal field and tissue damage analysis for cardiac tumor ablation

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Abstract

Radiofrequency ablation is a nominally invasive technique to eradicate cancerous or non-cancerous cells by heating. However, it is still hampered to acquire a successful cell destruction process due to inappropriate RF intensities that will not entirely obliterate tumorous tissues, causing in treatment failure. In this study, we are acquainted with a nanoassisted RF ablation procedure of cardiac tumor to provide better outcomes for long-term survival rate without any recurrences. A three-dimensional thermo-electric energy model is employed to investigate nanothermal field and ablation efficiency into the left atrium tumor. The cell death model is adopted to quantify the degree of tissue injury while injecting the Fe3O4 nanoparticles concentrations up to 20% into the target tissue. The results reveal that when nanothermal field extents as a function of tissue depth (10 mm) from the electrode tip, the increasing thermal rates were approximately 0.54362%, 3.17039%, and 7.27397% for the particle concentration levels of 7%, 10%, and 15% compared with no-particle case. In the 7% Fe3O4 nanoparticles, 100% fractional damage index is achieved after ablation time of 18 s whereas tissue annihilation approach proceeds longer to complete for no-particle case. The outcomes indicate that injecting nanoparticles may lessen ablation time in surgeries and prevent damage to adjacent healthy tissue.

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Abbreviations

\(\theta\) (°C):

Temperature

t (s):

Time

c (J kg−1 °C−1):

Specific heat

k (W m−1 °C−1):

Thermal conductivity

\({q}_{RF}\) (W m−3):

Volumetric heat source

\({Q}_{m}\) (W m−3):

Metabolic heat source

J (A m−2):

Electric current density

\({J}_{e}\) (A m−2):

External electric current density

E (V m−1):

Electric field intensity

V (V):

Electric potential

(x, y, z):

Cartesian coordinate system

ρ (kg m−3):

Tissue density

ρ b (kg m−3):

Blood density

\({\omega }_{b}({s}^{-1})\) :

Blood perfusion rate

\({\omega }_{b0}({s}^{-1})\) :

Constant blood perfusion of tissue/tumor

\(\alpha (t)\) :

Cumulative tissue damage

\({\Omega }_{d}\) :

Fraction of necrotic tissue

\(\sigma (S\ {m}^{-1})\)  :

Electrical conductivity

\(\eta\) :

Particle volume fractions

b:

Blood

eff:

Effective

max:

Maximum

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Funding

This work was partially supported by the Ministry of Science and Technology, Government of the People’s Republic of Bangladesh, and the Centennial Research Grant, University of Dhaka, Dhaka, Bangladesh.

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Authors and Affiliations

  1. Department of Applied Mathematics, University of Dhaka, Dhaka, 1000, Bangladesh

    S. M. C. Hossain, J. B. Zakaria, M. Ferdows & M. Z. I. Bangalee

  2. Department of Electronic Engineering and Information Science, University of Science and Technology of China, Hefei, 230027, China

    S. M. C. Hossain & G. Zhao

  3. Department of Mathematics, Jagannath University, Dhaka, 1100, Bangladesh

    M. S. Alam

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  1. S. M. C. Hossain
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The original online version of this article was revised: The text "0.17em" has been removed in equations 1, 3, 6, 7, 8, 10, 11, 13, 14.

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Hossain, S.M.C., Zakaria, J.B., Ferdows, M. et al. Computer simulation-based nanothermal field and tissue damage analysis for cardiac tumor ablation. Med Biol Eng Comput 62, 1549–1567 (2024). https://doi.org/10.1007/s11517-024-03017-y

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