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Cellular, physiological and pathological aspects of the long non-coding RNA NEAT1

  • Review
  • Published:
Frontiers in Biology

Abstract

BACKGROUND

The majority of mammalian genomes have been found to be transcribed into non-coding RNAs. One category of non-coding RNAs is classified as long non-coding RNAs (lncRNAs) based on their transcript sizes larger than 200 nucleotides. Growing evidence has shown that lncRNAs are not junk transcripts and play regulatory roles in multiple aspects of biological processes. Dysregulation of lncRNA expression has also been linked to diseases, in particular cancer. Therefore, studies of lncRNAs have attracted significant interest in the field of medical research. Nuclear enriched abundant transcript 1 (NEAT1), a nuclear lncRNA, has recently emerged as a key regulator involved in various cellular processes, physiological responses, developmental processes, and disease development and progression.

OBJECTIVE

This review will summarize and discuss the most recent findings with regard to the roles of NEAT1 in the function of the nuclear paraspeckle, cellular pathways, and physiological responses and processes. Particularly, the most recently reported studies regarding the pathological roles of deregulated NEAT1 in cancer are highlighted in this review.

METHODS

We performed a systematic literature search using the Pubmed search engine. Studies published over the past 8 years (between January 2009 and August 2016) were the sources of literature review. The following keywords were used: “Nuclear enriched abundant transcript 1,” “NEAT1,” and “paraspeckles.”

RESULTS

The Pubmed search identified 34 articles related to the topic of the review. Among the identified literature, 13 articles report findings related to cellular functions of NEAT1 and eight articles are the investigations of physiological functions of NEAT1. The remaining 13 articles are studies of the roles of NEAT1 in cancers.

CONCLUSION

Recent advances in NEAT1 studies reveal the multifunctional roles of NEAT1 in various biological processes, which are beyond its role in nuclear paraspeckles. Recent studies also indicate that dysregulation of NEAT1 function contributes to the development and progression of various cancers. More investigations will be needed to address the detailed mechanisms regarding how NEAT1 executes its cellular and physiological functions and how NEAT1 dysregulation results in tumorigenesis, and to explore the potential of NEAT1 as a target in cancer diagnosis, prognosis and therapy.

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Acknowledgments

This work was supported by National Institutes of Health (NIH) R01 grants [grant numbers 5R01CA157779-03, 5R01CA163820-04] to Q.Z.

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  1. Department of Biochemistry and Molecular Biology, Greenebaum Cancer Center, University of Maryland School of Medicine, Baltimore, MD, 21201, USA

    Pang-Kuo Lo, Benjamin Wolfson & Qun Zhou

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  1. Pang-Kuo Lo
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  2. Benjamin Wolfson
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  3. Qun Zhou
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Correspondence to Qun Zhou.

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Lo, PK., Wolfson, B. & Zhou, Q. Cellular, physiological and pathological aspects of the long non-coding RNA NEAT1. Front. Biol. 11, 413–426 (2016). https://doi.org/10.1007/s11515-016-1433-z

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