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IL-23 in Infections, Inflammation, Autoimmunity and Cancer: Possible Role in HIV-1 and AIDS

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Abstract

The growing family of interleukin (IL)-12-like cytokines produced by activated macrophages and dendritic cells became the important players in the control of infections, development of inflammation, autoimmunity and cancer. However, the role of one of them—heterodimer IL-23, which consists of IL12p40 and the unique p19 subunit in HIV-1 infection pathogenesis and progression to AIDS, represent special interest. We overviewed findings of IL-23 involvement in control of peripheral bacterial pathogens and opportunistic infection, central nervous system (CNS) viral infections and autoimmune disorders, and tumorogenesis, which potentially could be applicable to HIV-1 and AIDS.

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Acknowledgments

This work was supported by National Institutes of Health Grants 5 P20 RR021937-02, 5 P01 NS043985-07. We acknowledge Deepa Roy, Jaclyn Knibbe, Edward Makarov, Santhi Gorantla for assistance.

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There are no conflicts of interest for any of the authors.

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  1. Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, NE, USA

    Govardhana Rao Yannam, Tanuja Gutti & Larisa Y. Poluektova

  2. 985880 Nebraska Medical Center, Omaha, NE, USA

    Larisa Y. Poluektova

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  1. Govardhana Rao Yannam
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Yannam, G.R., Gutti, T. & Poluektova, L.Y. IL-23 in Infections, Inflammation, Autoimmunity and Cancer: Possible Role in HIV-1 and AIDS. J Neuroimmune Pharmacol 7, 95–112 (2012). https://doi.org/10.1007/s11481-011-9315-2

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