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Methamphetamine-Induced Behavioral and Physiological Effects in Adolescent and Adult HIV-1 Transgenic Rats

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Abstract

We recently reported that six consecutive days of treatment with a moderate dose of methamphetamine (METH) induced greater behavioral sensitization in adult HIV-1 transgenic (HIV-1 Tg) rats than in adult Fischer 344/NHsd (F344) non-transgenic, wild-type control animals. In the present study, we evaluated the effects of a moderate dose of METH on the brains of adolescent versus adult HIV-1 Tg male rats using both behavioral (METH-induced, stereotypic head movement) and physiological (rectal body temperature) parameters. We found that both the acute and behavior-sensitizing effects of METH were greater in HIV-1 Tg rats compared with controls and also in adolescent rats compared with adult animals, regardless of HIV-1 status. We determined that acute hyperthermic effects of METH as well as tolerance to METH-induced hyperthermia were greater in HIV-1 Tg rats than in controls. Taken together, these results suggest that both the neuroadaptations seen in HIV infection and the immaturity of the adolescent brain are associated with increased sensitivity to the psychoactive and behavior-sensitizing properties of METH. Thus, HIV-infected individuals and adolescents may be more vulnerable to the development of METH abuse and dependence than non-infected individuals and adults.

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Authors and Affiliations

  1. Institute of NeuroImmune Pharmacology, Seton Hall University, 400 South Orange Avenue, South Orange, NJ, 07079, USA

    Marley D. Kass, Xiangqian Liu, Michael Vigorito & Sulie L. Chang

  2. Department of Psychology, Seton Hall University, 400 South Orange Avenue, South Orange, NJ, 07079, USA

    Michael Vigorito

  3. Department of Medicine, Division of Neurology, John A. Burns School of Medicine, University of Hawai`i at Manoa, Honolulu, HI, 96813, USA

    Linda Chang

  4. Department of Biological Sciences, Seton Hall University, 400 South Orange Avenue, South Orange, NJ, 07079, USA

    Sulie L. Chang

Authors
  1. Marley D. Kass
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  2. Xiangqian Liu
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  3. Michael Vigorito
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  4. Linda Chang
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  5. Sulie L. Chang
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Corresponding author

Correspondence to Sulie L. Chang.

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Guarantors of the work: Sulie L. Chang

Source of support: Supported, in part, by NIH K24 grant DA16170 to LC and NIH K02 grant DA016149 to SLC.

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Kass, M.D., Liu, X., Vigorito, M. et al. Methamphetamine-Induced Behavioral and Physiological Effects in Adolescent and Adult HIV-1 Transgenic Rats. J Neuroimmune Pharmacol 5, 566–573 (2010). https://doi.org/10.1007/s11481-010-9221-z

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  • DOI: https://doi.org/10.1007/s11481-010-9221-z

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