Zusammenfassung
Die Prävalenz des metabolischen Syndroms und des Diabetes mellitus Typ 2 steigt weltweit an, daraus resultiert eine vorzeitige kardiovaskuläre Mortalität. Dies wird vor allem auf die steigende Adipositasprävalenz zurückgeführt. Allerdings konnte durch zahlreiche klinische und epidemiologische Studien gezeigt werden, dass hohe Fitnesslevel der Entwicklung dieser metabolischen Störungen entgegenwirken und zugleich die kardiovaskuläre Mortalität verringern. Beim Vergleich der beiden Parameter ist eine gute kardiorespiratorische Fitness in der Prävention des metabolischen Syndroms, des Diabetes mellitus Typ 2 und kardiovaskulärer Erkrankungen ein bedeutenderer Einflussfaktor als Übergewicht. Im Rahmen der Prävention kardiovaskulärer und metabolischer Erkrankungen ist es daher notwendig, durch Erhöhung der körperlichen Aktivität den Fitnesszustand zu verbessern.
Abstract
The prevalence of metabolic syndrome and type 2 diabetes mellitus is increasing worldwide, resulting in premature cardiovascular mortality. This has been attributed to the increasing prevalence of obesity. However, multiple clinical and epidemiologic studies have also shown that high levels of cardiorespiratory fitness protect against the development of these metabolic disorders and at the same time reduce cardiovascular mortality. When comparing both parameters, cardiorespiratory fitness has been shown to be a more powerful parameter in the prevention of metabolic syndrome, type 2 diabetes, and cardiovascular disease than obesity. Thus, to prevent cardiovascular disease, it is mandatory to promote physical activity that will increase physical fitness. An English fulltext version of this article is available under Springerlink as supplemental material.
Literatur
Must A, Spadano J, Coakley EH et al (1999) The disease burden associated with overweight and obesity. JAMA 282(16):1523–1529
Park YW, Zhu S, Palaniappan L et al (2003) The metabolic syndrome: prevalence and associated risk factor findings in the US population from the Third National Health and Nutrition Examination Survey, 1988–1994. Arch Intern Med 163(4):427–436
Lakka HM, Laaksonen DE, Lakka TA et al (2002) The metabolic syndrome and total and cardiovascular disease mortality in middle-aged men. JAMA 288(21):2709–2716
Carnethon MR, Gulati M, Greenland P (2005) Prevalence and cardiovascular disease correlates of low cardiorespiratory fitness in adolescents and adults. JAMA 294(23):2981–2988
Ekelund U, Brage S, Franks PW et al (2005) Physical activity energy expenditure predicts progression toward the metabolic syndrome independently of aerobic fitness in middle-aged healthy Caucasians: The Medical Research Council Ely Study. Diabetes Care 28(5):1195–1200
Franks PW, Ekelund U, Brage S et al (2004) Does the association of habitual physical activity with the metabolic syndrome differ by level of cardiorespiratory fitness? Diabetes Care 27(5):1187–1193
Hassinen M, Lakka TA, Savonen K et al (2008) Cardiorespiratory fitness as a feature of metabolic syndrome in older men and women: the Dose-Responses to Exercise Training study (DR’s EXTRA). Diabetes Care 31(6):1242–1247
Laaksonen DE, Lakka HM, Salonen JT et al (2002) Low levels of leisure-time physical activity and cardiorespiratory fitness predict development of the metabolic syndrome. Diabetes Care 25(9):1612–1618
Lakka TA, Laaksonen DE, Lakka HM et al (2003) Sedentary lifestyle, poor cardiorespiratory fitness, and the metabolic syndrome. Med Sci Sports Exerc 35(8):1279–1286
Tuomilehto J, Lindstrom J, Eriksson JG et al (2001) Prevention of type 2 diabetes mellitus by changes in lifestyle among subjects with impaired glucose tolerance. N Engl J Med 344(18):1343–1350
Leite SA, Monk AM, Upham PA, Bergenstal RM (2009) Low cardiorespiratory fitness in people at risk for type 2 diabetes: early marker for insulin resistance. Diabetol Metab Syndr 1(1):8
Matthews DR, Hosker JP, Rudenski AS et al (1985) Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia 28(7):412–419
Hassinen M, Lakka TA, Hakola L et al (2010) Cardiorespiratory fitness and metabolic syndrome in older men and women: the dose responses to Exercise Training (DR’s EXTRA) study. Diabetes Care 33(7):1655–1657
Carnethon MR, Gidding SS, Nehgme R et al (2003) Cardiorespiratory fitness in young adulthood and the development of cardiovascular disease risk factors. JAMA 290(23):3092–3100
Imperatore G, Cheng YJ, Williams DE et al (2006) Physical activity, cardiovascular fitness, and insulin sensitivity among U.S. adolescents: the National Health and Nutrition Examination Survey, 1999–2002. Diabetes Care 29(7):1567–1572
Cummings DM, Dubose KD, Imai S, Collier DN (2010) Fitness versus fatness and insulin resistance in U.S. adolescents. Int J Obes (Lond) 2010
Executive Summary of The Third Report of The National Cholesterol Education Program (NCEP) (2001) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III). JAMA 285(19):2486–2497
Harris MI, Flegal KM, Cowie CC et al (1998) Prevalence of diabetes, impaired fasting glucose, and impaired glucose tolerance in U.S. adults. The Third National Health and Nutrition Examination Survey, 1988–1994. Diabetes Care 21(4):518–524
Marrero DG (2009) The prevention of type 2 diabetes: an overview. J Diabetes Sci Technol 3(4):756–760
Mokdad AH, Ford ES, Bowman BA et al (2003) Prevalence of obesity, diabetes, and obesity-related health risk factors, 2001. JAMA 289(1):76–79
Chan JM, Rimm EB, Colditz GA et al (1994) Obesity, fat distribution, and weight gain as risk factors for clinical diabetes in men. Diabetes Care 17(9):961–969
Carey VJ, Walters EE, Colditz GA et al (1997) Body fat distribution and risk of non-insulin-dependent diabetes mellitus in women. The Nurses’ Health Study. Am J Epidemiol 145(7):614–619
Carnethon MR, Sternfeld B, Schreiner PJ et al (2009) Association of 20-year changes in cardiorespiratory fitness with incident type 2 diabetes: the coronary artery risk development in young adults (CARDIA) fitness study. Diabetes Care 32(7):1284–1288
Pan XR, Li GW, Hu YH et al (1997) Effects of diet and exercise in preventing NIDDM in people with impaired glucose tolerance. The Da Qing IGT and Diabetes Study. Diabetes Care 20(4):537–544
Wei M, Gibbons LW, Mitchell TL et al (1999) The association between cardiorespiratory fitness and impaired fasting glucose and type 2 diabetes mellitus in men. Ann Intern Med 130(2):89–96
Carnethon MR, Craft LL (2008) Autonomic regulation of the association between exercise and diabetes. Exerc Sport Sci Rev 36(1):12–18
Kraus WE, Slentz CA (2009) Exercise training, lipid regulation, and insulin action: a tangled web of cause and effect. Obesity (Silver Spring) 17(Suppl 3):S21–S26
Lamonte MJ, Blair SN, Church TS (2005) Physical activity and diabetes prevention. J Appl Physiol 99(3):1205–1213
Melanson EL, Freedson PS (2001) The effect of endurance training on resting heart rate variability in sedentary adult males. Eur J Appl Physiol 85(5):442–449
Perseghin G, Price TB, Petersen KF et al (1996) Increased glucose transport-phosphorylation and muscle glycogen synthesis after exercise training in insulin-resistant subjects. N Engl J Med 335(18):1357–1362
Knowler WC, Barrett-Connor E, Fowler SE et al (2002) Reduction in the incidence of type 2 diabetes with lifestyle intervention or metformin. N Engl J Med 346(6):393–403
Lindstrom J, Ilanne-Parikka P, Peltonen M et al (2006) Sustained reduction in the incidence of type 2 diabetes by lifestyle intervention: follow-up of the Finnish Diabetes Prevention Study. Lancet 368(9548):1673–1679
Pi-Sunyer X, Blackburn G, Brancati FL et al (2007) Reduction in weight and cardiovascular disease risk factors in individuals with type 2 diabetes: one-year results of the look AHEAD trial. Diabetes Care 30(6):1374–1383
Bennett WL, Ouyang P, Wu AW et al (2008) Fatness and fitness: how do they influence health-related quality of life in type 2 diabetes mellitus? Health Qual Life Outcomes 6:110
Blair SN, Kohl HW III, Paffenbarger RS Jr et al (1989) Physical fitness and all-cause mortality. A prospective study of healthy men and women. JAMA 262(17):2395–2401
Blair SN, Kohl HW III, Barlow CE et al (1995) Changes in physical fitness and all-cause mortality. A prospective study of healthy and unhealthy men. JAMA 273(14):1093–1098
Katzmarzyk PT, Church TS, Blair SN (2004) Cardiorespiratory fitness attenuates the effects of the metabolic syndrome on all-cause and cardiovascular disease mortality in men. Arch Intern Med 164(10):1092–1097
Katzmarzyk PT, Church TS, Janssen I et al (2005) Metabolic syndrome, obesity, and mortality: impact of cardiorespiratory fitness. Diabetes Care 28(2):391–397
Church TS, Lamonte MJ, Barlow CE, Blair SN (2005) Cardiorespiratory fitness and body mass index as predictors of cardiovascular disease mortality among men with diabetes. Arch Intern Med 165(18):2114–2120
Myers J, Prakash M, Froelicher V et al (2002) Exercise capacity and mortality among men referred for exercise testing. N Engl J Med 346(11):793–801
Interessenkonflikt
Der korrespondierende Autor weist auf folgende Beziehungen hin: M. Halle: Vortragstätigkeit für Pharmafirmen MSD, Astra Zeneca, Berlin-Chemie, Roche, Sanofi-Aventis, Techniker Krankenkasse.
Author information
Authors and Affiliations
Corresponding author
Electronic supplementary material
Rights and permissions
About this article
Cite this article
Esefeld, K., Halle, M. & Blair, S. Eingeschränkte Fitness vs. Adipositas. Diabetologe 7, 9–14 (2011). https://doi.org/10.1007/s11428-010-0614-7
Published:
Issue Date:
DOI: https://doi.org/10.1007/s11428-010-0614-7
Schlüsselwörter
- Kardiovaskuläre Erkrankungen
- Metabolisches Syndrom
- Kardiorespiratorische Fitness
- Adipositas
- Primärprävention