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A thorough analysis of diabetes research in China from 1995 to 2015: current scenario and future scope

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An Erratum to this article was published on 26 June 2023

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Abstract

The prevalence of diabetes has increased dramatically over the past three decades, and currently, China has the largest number of diabetics worldwide; this number continues to grow and puts ongoing strains on the medical resources. In this review, we reviewed the diabetes research conducted in China from 1995 to 2015 with the aim of providing new insights regarding the current status and future perspectives for researchers, diabetes health providers, and respective policy-makers. Remarkable progress has been made in diabetes research in China during the past two decades in terms of both the quantity and publication influence. The progress, however, struggles to adequately manage diabetes in China. Here we addressed opportunities to strengthen researches, including new drug development, high quality studies on health economics, and healthcare quality improvement studies. As the expected wave of diabetic complications is upcoming and overwhelming, we therefore recommend that immediate improvements are required to implement the researches regarding their prevention and treatment.

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References

  • American Diabetes Association, (2010). Standards of medical care in diabetes—2010. Diabetes Care 33, S11–S61.

  • Bao, Y., Ma, X., Li, H., Zhou, M., Hu, C., Wu, H., Tang, J., Hou, X., Xiang, K., and Jia, W. (2010). Glycated haemoglobin A1c for diagnosing diabetes in Chinese population: cross sectional epidemiological survey. BMJ 340, c2249.

    Article  PubMed  PubMed Central  Google Scholar 

  • Bennett, C., Guo, M., and Dharmage, S. (2007). HbA(1c) as a screening tool for detection of Type 2 diabetes: a systematic review. Diabet Med 24, 333–343.

    Article  CAS  PubMed  Google Scholar 

  • Chen, A., Huang, Z., Wan, X., Deng, W., Wu, J., Li, L., Cai, Q., Xiao, H., and Li, Y. (2012). Attitudes toward diabetes affect maintenance of drugfree remission in patients with newly diagnosed type 2 diabetes after short-term continuous subcutaneous insulin infusion treatment. Diabetes Care 35, 474–481.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Chen, X., Ba, Y., Ma, L., Cai, X., Yin, Y., Wang, K., Guo, J., Zhang, Y., Chen, J., Guo, X., et al. (2008). Characterization of microRNAs in serum: a novel class of biomarkers for diagnosis of cancer and other diseases. Cell Res 18, 997–1006.

    Article  CAS  PubMed  Google Scholar 

  • Chinese Diabetes Society. China Guideline For Diabetes (2007 Ed) (in Chinese). (2008). Zhonghua Yi Xue Za Zhi 88, 1227–1245.

  • Chinese Diabetes Society. China Guideline for Type 1 Diabetes-2011 (in Chinese). https://doi.org/www.diab.net.cn/uploadfile/ueditor/file/20160811/636-0650788212125003136602.pdf, 2017-07-01.

  • Chinese Diabetes Society. China Guideline For Type 2 Diabetes (2010 Ed). (2012). Chin J Diabetes 20, S1–S36.

  • Chinese Diabetes Society. China Guideline For Type 2 Diabetes (2013 Ed). (2014). Chin J Diabetes Mellitus 6, 447–498.

  • Chiu, M., Austin, P.C., Manuel, D.G., Shah, B.R., and Tu, J.V. (2011). Deriving ethnic-specific BMI cutoff points for assessing diabetes risk. Diabetes Care 34, 1741–1748.

    Article  PubMed  PubMed Central  Google Scholar 

  • Cui, B., Zhu, X., Xu, M., Guo, T., Zhu, D., Chen, G., Li, X., Xu, L., Bi, Y., Chen, Y., et al. (2011). A genome-wide association study confirms previously reported loci for type 2 diabetes in Han Chinese. PLoS ONE 6, e22353.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Cui, G., Zhang, Y., Gong, Z., Zhang, J.Z., and Zang, Y.Q. (2009). Induction of CD4+CD25+Foxp3+ regulatory T cell response by glatiramer acetate in type 1 diabetes. Cell Res 19, 574–583.

    Article  CAS  PubMed  Google Scholar 

  • Dagogo-Jack, S. (2010). Pitfalls in the use of HbA1c as a diagnostic test: the ethnic conundrum. Nat Rev Endocrinol 6, 589–593.

    Article  CAS  PubMed  Google Scholar 

  • Dong, B., Yu, Q.T., Dai, H.Y., Gao, Y.Y., Zhou, Z.L., Zhang, L., Jiang, H., Gao, F., Li, S.Y., Zhang, Y.H., et al. (2012). Angiotensin-converting enzyme-2 overexpression improves left ventricular remodeling and function in a rat model of diabetic cardiomyopathy. J Am College Cardiol 59, 739–747.

    Article  CAS  Google Scholar 

  • Dong, X., He, M., Song, X., Lu, B., Yang, Y., Zhang, S., Zhao, N., Zhou, L., Li, Y., Zhu, X., et al. (2007). Performance and comparison of the Cockcroft-Gault and simplified Modification of Diet in Renal Disease formulae in estimating glomerular filtration rate in a Chinese Type 2 diabetic population. Diabetic Med 24, 1482–1486.

    Article  CAS  PubMed  Google Scholar 

  • Feng, R., Li, K., Cheng, J., Xie, S., Chai, J., Wei, P., and Wang, D. (2013). Toward integrated and sustainable prevention against diabetes in rural China: study rationale and protocol of eCROPS. BMC Endocr Disord 13, 28.

    Article  PubMed  PubMed Central  Google Scholar 

  • Flegal, K.M., Carroll, M.D., Kit, B.K., and Ogden, C.L. (2012). Prevalence of obesity and trends in the distribution of body mass index among US adults, 1999–2010. JAMA 307, 491–497.

    Article  PubMed  Google Scholar 

  • Fox, C.S., Golden, S.H., Anderson, C., Bray, G.A., Burke, L.E., de Boer, I. H., Deedwania, P., Eckel, R.H., Ershow, A.G., Fradkin, J., et al. (2015). Update on prevention of cardiovascular disease in adults with type 2 diabetes mellitus in light of recent evidence: a scientific statement from the American Heart Association and the American Diabetes Association. Diabetes Care 38, 1777–1803.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Geiss, L.S., Wang, J., Cheng, Y.J., Thompson, T.J., Barker, L., Li, Y., Albright, A.L., and Gregg, E.W. (2014). Prevalence and incidence trends for diagnosed diabetes among adults aged 20 to 79 years, United States, 1980–2012. JAMA 312, 1218–1226.

    Article  CAS  PubMed  Google Scholar 

  • Gong, Q., Gregg, E.W., Wang, J., An, Y., Zhang, P., Yang, W., Li, H., Li, H., Jiang, Y., Shuai, Y., et al. (2011). Long-term effects of a randomised trial of a 6-year lifestyle intervention in impaired glucose tolerance on diabetes-related microvascular complications: the China Da Qing Diabetes Prevention Outcome Study. Diabetologia 54, 300–307.

    Article  CAS  PubMed  Google Scholar 

  • Gregg, E.W., Li, Y., Wang, J., Rios Burrows, N., Ali, M.K., Rolka, D., Williams, D.E., and Geiss, L. (2014). Changes in diabetes-related complications in the United States, 1990–2010. N Engl J Med 370, 1514–1523.

    Article  CAS  PubMed  Google Scholar 

  • Gu, D., Reynolds, K., Duan, X., Xin, X., Chen, J., Wu, X., Mo, J., Whelton, P.K., He, J., and He, J. (2003). Prevalence of diabetes and impaired fasting glucose in the Chinese adult population: International Collaborative Study of Cardiovascular Disease in Asia (InterASIA). Diabetologia 46, 1190–1198.

    Article  CAS  PubMed  Google Scholar 

  • Gu, W., Hu, J., Wang, W., Li, L., Tang, W., Sun, S., Cui, W., Ye, L., Zhang, Y., Hong, J., et al. (2012). Diabetic ketoacidosis at diagnosis influences complete remission after treatment with hematopoietic stem cell transplantation in adolescents with type 1 diabetes. Diabetes Care 35, 1413–1419.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Gu, Y., Wang, X., Li, J., Zhang, Y., Zhong, H., Liu, R., Zhang, D., Feng, Q., Xie, X., Hong, J., et al. (2017). Analyses of gut microbiota and plasma bile acids enable stratification of patients for antidiabetic treatment. Nat Commun 8, 1785.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Gu, Y., Zhang, Y., Shi, X., Li, X., Hong, J., Chen, J., Gu, W., Lu, X., Xu, G., and Ning, G. (2010). Effect of traditional Chinese medicine berberine on type 2 diabetes based on comprehensive metabonomics. Talanta 81, 766–772.

    Article  CAS  PubMed  Google Scholar 

  • He, A., Zhu, L., Gupta, N., Chang, Y., and Fang, F. (2007). Overexpression of micro ribonucleic acid 29, highly up-regulated in diabetic rats, leads to insulin resistance in 3t3-l1 adipocytes. Mol Endocrinol 21, 2785–2794.

    Article  CAS  PubMed  Google Scholar 

  • Hong, J., Zhang, Y., Lai, S., Lv, A., Su, Q., Dong, Y., Zhou, Z., Tang, W., Zhao, J., Cui, L., et al. (2013). Effects of metformin versus glipizide on cardiovascular outcomes in patients with type 2 diabetes and coronary artery disease. Diabetes Care 36, 1304–1311.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Huang, C., Zhang, Y., Gong, Z., Sheng, X., Li, Z., Zhang, W., and Qin, Y. (2006). Berberine inhibits 3T3-L1 adipocyte differentiation through the PPAR? pathway. Biochem Biophys Res Commun 348, 571–578.

    Article  CAS  PubMed  Google Scholar 

  • International Diabetes Federation. IDF Diabetes Atlas, 8th ed. (2017). Brussels, Belgium: International Diabetes Federation.

  • Ji, L., Hu, D., Pan, C., Weng, J., Huo, Y., Ma, C., Mu, Y., Hao, C., Ji, Q., and Ran, X. (2013). Primacy of the 3B approach to control risk factors for cardiovascular disease in type 2 diabetes patients. Am J Med 126, 925.e911–925.e922.

    Article  Google Scholar 

  • Ji, L., Ma, J., Li, H., Mansfield, T.A., T’joen, C.L., Iqbal, N., Ptaszynska, A., and List, J.F. (2014). Dapagliflozin as monotherapy in drug-naive Asian patients with type 2 diabetes mellitus: a randomized, blinded, prospective phase III study. Clin Therapeut 36, 84–100.e9.

    Article  CAS  Google Scholar 

  • Ji, L., Tong, X., Wang, H., Tian, H., Zhou, H., Zhang, L., Li, Q., Wang, Y., Li, H., Liu, M., et al. (2013). Efficacy and safety of traditional Chinese medicine for diabetes: a double-blind, randomised, controlled trial. PLoS ONE 8, e56703.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Jia, W., Xiao, X., Ji, Q., Ahn, K.J., Chuang, L.M., Bao, Y., Pang, C., Chen, L., Gao, F., Tu, Y., et al. (2015). Efficacy and safety of traditional Chinese medicine for diabetes: a double-blind, randomised, controlled trial. Lancet Diabetes Endocrinol 3, 254–262.

    Article  CAS  PubMed  Google Scholar 

  • Jiang, H., Chen, W., Bi, K., and Ying, X. (2009). Are services delivered by community health centers more cost-effective? Evidence from urban China. Health Econ 18, S107–S117.

    Article  PubMed  Google Scholar 

  • Jiang, W., Shi, Y., Zhao, D., Chen, S., Yong, J., Zhang, J., Qing, T., Sun, X., Zhang, P., Ding, M., et al. (2007). In vitro derivation of functional insulin-producing cells from human embryonic stem cells. Cell Res 17, 333–344.

    Article  CAS  PubMed  Google Scholar 

  • Leng, J., Shao, P., Zhang, C., Tian, H., Zhang, F., Zhang, S., Dong, L., Li, L., Yu, Z., Chan, J.C.N., et al. (2015). Prevalence of gestational diabetes mellitus and its risk factors in Chinese pregnant women: a prospective population-based study in Tianjin, China. PLoS ONE 10, e0121029.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Leng, S., Lu, F., and Xu, L. (2004). Therapeutic effects of berberine in impaired glucose tolerance rats and its influence on insulin secretion. Acta Pharmacol Sin 25, 496–502.

    CAS  PubMed  Google Scholar 

  • Li, G., Zhang, P., Wang, J., An, Y., Gong, Q., Gregg, E.W., Yang, W., Zhang, B., Shuai, Y., Hong, J., et al. (2014). Cardiovascular mortality, all-cause mortality, and diabetes incidence after lifestyle intervention for people with impaired glucose tolerance in the Da Qing Diabetes Prevention Study: a 23-year follow-up study. Lancet Diabetes Endocrinol 2, 474–480.

    Article  PubMed  Google Scholar 

  • Li, G., Zhang, P., Wang, J., Gregg, E.W., Yang, W., Gong, Q., Li, H., Li, H., Jiang, Y., An, Y., et al. (2008). The long-term effect of lifestyle interventions to prevent diabetes in the China Da Qing Diabetes Prevention Study: a 20-year follow-up study. Lancet 371, 1783–1789.

    Article  PubMed  Google Scholar 

  • Li, H., Gan, W., Lu, L., Dong, X., Han, X., Hu, C., Yang, Z., Sun, L., Bao, W., Li, P., et al. (2013). A genome-wide association study identifies GRK5 and RASGRP1 as type 2 diabetes loci in Chinese Hans. Diabetes 62, 291–298.

    Article  CAS  PubMed  Google Scholar 

  • Li, J., Yang, D., Yan, J., Huang, B., Zhang, Y., Weng, J., and Weng, J. (2014). Secondary diabetic ketoacidosis and severe hypoglycaemia in patients with established type 1 diabetes mellitus in china: a multicentre registration study. Diabetes Metab Res Rev 30, 497–504.

    Article  CAS  PubMed  Google Scholar 

  • Li, W., Zhang, S., Liu, H., Wang, L., Zhang, C., Leng, J., Yu, Z., Yang, X., Tian, H., and Hu, G. (2014). Different associations of diabetes with β-cell dysfunction and insulin resistance among obese and nonobese chinese women with prior gestational diabetes mellitus. Diabetes Care 37, 2533–2539.

    Article  PubMed  Google Scholar 

  • Li, Y., Xu, W., Liao, Z., Yao, B., Chen, X., Huang, Z., Hu, G., and Weng, J. (2004). Induction of long-term glycemic control in newly diagnosed type 2 diabetic patients is associated with improvement of β-cell function. Diabetes Care 27, 2597–2602.

    Article  CAS  PubMed  Google Scholar 

  • Lian, F., Li, G., Chen, X., Wang, X., Piao, C., Wang, J., Hong, Y., Ba, Z., Wu, S., Zhou, X., et al. (2014). Chinese herbal medicine Tianqi reduces progression from impaired glucose tolerance to diabetes: a double-blind, randomized, placebo-controlled, multicenter trial. J Clin Endocrinol Metab 99, 648–655.

    Article  CAS  PubMed  Google Scholar 

  • Liao, S., Mei, J., Song, W., Liu, Y., Tan, Y.D., Chi, S., Li, P., Chen, X., and Deng, S. (2014). The impact of the International Association of Diabetes and Pregnancy Study Groups (IADPSG) fasting glucose diagnostic criterion on the prevalence and outcomes of gestational diabetes mellitus in Han Chinese women. Diabet Med 31, 341–351.

    Article  CAS  PubMed  Google Scholar 

  • Lin, J., Zhou, Z.G., Wang, J.P., Zhang, C., and Huang, G. (2008). From type 1, through LADA, to type 2 diabetes: a continuous spectrum? Ann New York Acad Sci 1150, 99–102.

    Article  CAS  Google Scholar 

  • Lin, S., Han, Y., Shi, Y., Rong, H., Zheng, S., Jin, S., Lin, S.Y., Lin, S.C., and Li, Y. (2012). Revealing a steroid receptor ligand as a unique PPAR? agonist. Cell Res 22, 746–756.

    Article  CAS  PubMed  Google Scholar 

  • Liu, F., Song, R., Feng, Y., Guo, J., Chen, Y., Zhang, Y., Chen, T., Wang, Y., Huang, Y., Li, C.Y., et al. (2015). Upregulation of MG53 induces diabetic cardiomyopathy through transcriptional activation of peroxisome proliferation-activated receptor a. Circulation 131, 795–804.

    Article  CAS  PubMed  Google Scholar 

  • Liu, L., Furuta, H., Minami, A., Zheng, T., Jia, W., Nanjo, K., and Xiang, K. (2007). A novel mutation, Ser159Pro in the NeuroD1/BETA2 gene contributes to the development of diabetes in a Chinese potential MODY family. Mol Cell Biochem 303, 115–120.

    Article  CAS  PubMed  Google Scholar 

  • Lu, B., Song, X., Dong, X., Yang, Y., Zhang, Z., Wen, J., Li, Y., Zhou, L., Zhao, N., Zhu, X., et al. (2008). High prevalence of chronic kidney disease in population-based patients diagnosed with type 2 diabetes in downtown Shanghai. J Diabetes its Complications 22, 96–103.

    Article  Google Scholar 

  • Lu, B., Wen, J., Song, X.Y., Dong, X.H., Yang, Y.H., Zhang, Z.Y., Zhao, N. Q., Ye, H.Y., Mou, B., Chen, F.L., et al. (2007). High prevalence of albuminuria in population-based patients diagnosed with type 2 diabetes in the Shanghai downtown. Diabetes Res Clin Practice 75, 184–192.

    Article  CAS  Google Scholar 

  • Lu, Z., Pan, C., Gao, Y., Guo, L., Ning, G., Liu, Z., Lu, J., Jia, P., Wang, X., Sun S, et al. (2011). A randomized, double blind, placebo-controlled, parallel and multicenter study to evaluate the safety and efficacy of pioglitazone with sulphonylurea in type 2 diabetic patients (in Chinese). Zhonghua Nei Ke Za Zhi 50, 826–830.

    CAS  PubMed  Google Scholar 

  • Luan, B., Zhao, J., Wu, H., Duan, B., Shu, G., Wang, X., Li, D., Jia, W., Kang, J., and Pei, G. (2009). Deficiency of a β-arrestin-2 signal complex contributes to insulin resistance. Nature 457, 1146–1149.

    Article  CAS  PubMed  Google Scholar 

  • Luo, T.H., Zhao, Y., Li, G., Yuan, W.T., Zhao, J.J., Chen, J.L., Huang, W., and Luo, M. (2001). A genome-wide search for type ii diabetes susceptibility genes in Chinese Hans. Diabetologia 44, 501–506.

    Article  CAS  PubMed  Google Scholar 

  • Mayer-Davis, E.J., Lawrence, J.M., Dabelea, D., Divers, J., Isom, S., Dolan, L., Imperatore, G., Linder, B., Marcovina, S., Pettitt, D.J., et al. (2017). Incidence trends of type 1 and type 2 diabetes among youths, 2002–2012. N Engl J Med 377, 301.

    Article  PubMed  PubMed Central  Google Scholar 

  • Meng, Z.X., Nie, J., Ling, J.J., Sun, J.X., Zhu, Y.X., Gao, L., Lv, J.H., Zhu, D.Y., Sun, Y.J., and Han, X. (2009). Activation of liver x receptors inhibits pancreatic islet beta cell proliferation through cell cycle arrest. Diabetologia 52, 125–135.

    Article  CAS  PubMed  Google Scholar 

  • Mu, P., Chen, Y., Lu, H., Wen, X., Zhang, Y., Xie, R., Shu, J., Wang, M., and Zeng, L. (2012). Effects of a combination of oral anti-diabetes drugs with basal insulin therapy on β-cell function and glycaemic control in patients with newly diagnosed type 2 diabetes. Diabetes Metab Res Rev 28, 236–240.

    Article  CAS  PubMed  Google Scholar 

  • Nathan, D.M., Genuth, S., Lachin, J., Cleary, P., Crofford, O., Davis, M., Rand, L., and Siebert, C. (1993). The effect of intensive treatment of diabetes on the development and progression of long-term complications in insulin-dependent diabetes mellitus. N Engl J Med 329, 977–986.

    Article  CAS  PubMed  Google Scholar 

  • National Institute of Health. Glossay of NIH terms. https://doi.org/grants.nih.gov/grants/glossary.htm#C, 2017-04-04. National Science Foundation. What is Basic Science. https://doi.org/www.nsf.gov/pubs/1953/annualreports/ar_1953_sec6.pdf https://doi.org/grants.nih.gov/grants/glossary.htm#C, 2017-04-04. National Science Foundation. What is Basic Science. https://doi.org/www.nsf.gov/pubs/1953/annualreports/ar_1953_sec6.pdf, 2017-04-04.

  • NCD Risk Factor Collaboration (NCD-RisC). (2016). Worldwide trends in diabetes since 1980: a pooled analysis of 751 population-based studies with 4·4 million participants. The Lancet 387, 1513–1530.

  • Ohkubo, Y., Kishikawa, H., Araki, E., Miyata, T., Isami, S., Motoyoshi, S., Kojima, Y., Furuyoshi, N., and Shichiri, M. (1995). Intensive insulin therapy prevents the progression of diabetic microvascular complications in Japanese patients with non-insulin-dependent diabetes mellitus: a randomized prospective 6-year study. Diabetes Res Clin Practice 28, 103–117.

    Article  CAS  Google Scholar 

  • Pan, X., Li, G., Hu, Y., Wang, J., Yang, W., An, Z., Hu, Z., Lin, J., Xiao, J., Cao, H., et al. (1997). Effects of diet and exercise in preventing NIDDM in people with impaired glucose tolerance. The Da Qing IGT and Diabetes Study. Diabetes Care 20, 537–544.

    CAS  Google Scholar 

  • Pan, X.R., Yang, W.Y., Li, G.W., and Liu, J. (1994). Prevalence of diabetes and its risk factors in China, 1994. Diabetes Care 20, 1664–1669.

    Article  Google Scholar 

  • Pang, S., Tang, H., Zhuo, S., Zang, Y.Q., and Le, Y. (2010). Regulation of fasting fuel metabolism by Toll-Like Receptor 4. Diabetes 59, 3041–3048.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Patterson, C.C., Dahlquist, G.G., Gyürüs, E., Green, A., and Soltész, G. (2009). Incidence trends for childhood type 1 diabetes in Europe during 1989–2003 and predicted new cases 2005–20: a multicentre prospective registration study. Lancet 373, 2027–2033.

    Article  PubMed  Google Scholar 

  • Qin, J., Li, Y., Cai, Z., Li, S., Zhu, J., Zhang, F., Liang, S., Zhang, W., Guan, Y., Shen, D., et al. (2012). A metagenome-wide association study of gut microbiota in type 2 diabetes. Nature 490, 55–60.

    Article  CAS  PubMed  Google Scholar 

  • Qin, N., Yang, F., Li, A., Prifti, E., Chen, Y., Shao, L., Guo, J., Le Chatelier, E., Yao, J., Wu, L., et al. (2014). Alterations of the human gut microbiome in liver cirrhosis. Nature 513, 59–64.

    Article  CAS  PubMed  Google Scholar 

  • Qin, X., Xie, X., Fan, Y., Tian, J., Guan, Y., Wang, X., Zhu, Y., and Wang, N. (2008). Peroxisome proliferator-activated receptor-d induces insulininduced gene-1 and suppresses hepatic lipogenesis in obese diabetic mice. Hepatology 48, 432–441.

    Article  CAS  PubMed  Google Scholar 

  • Shang, M., and Lin, L. (2014). IADPSG criteria for diagnosing gestational diabetes mellitus and predicting adverse pregnancy outcomes. J Perinatol 34, 100–104.

    Article  CAS  PubMed  Google Scholar 

  • Shen, Y., Cai, M., Liang, H., Wang, H., and Weng, J. (2011). Insight into the biochemical characteristics of a novel glucokinase gene mutation. Hum Genet 129, 231–238.

    Article  CAS  PubMed  Google Scholar 

  • Shi, Y., Hou, L., Tang, F., Jiang, W., Wang, P., Ding, M., and Deng, H. (2005). Inducing embryonic stem cells to differentiate into pancreatic β cells by a novel three-step approach with activin A and all-trans retinoic acid. Stem Cells 23, 656–662.

    Article  CAS  PubMed  Google Scholar 

  • Shrestha, C., He, H., Liu, Y., Zhu, S., Xiong, J., and Mo, Z. (2013). Changes in adipokines following laparoscopic Roux-en-Y gastric bypass surgery in Chinese individuals with type 2 diabetes mellitus and BMI of 22–30 kg m-2. Int J Endocrinol 2013, 1–6.

    Google Scholar 

  • Song, R., Peng, W., Zhang, Y., Lv, F., Wu, H.K., Guo, J., Cao, Y., Pi, Y., Zhang, X., Jin, L., et al. (2013). Central role of E3 ubiquitin ligase MG53 in insulin resistance and metabolic disorders. Nature 494, 375–379.

    Article  CAS  PubMed  Google Scholar 

  • Sun, J., Furio, L., Mecheri, R., van der Does, A.M., Lundeberg, E., Saveanu, L., Chen, Y., van Endert, P., Agerberth, B., and Diana, J. (2015). Pancreatic β-cells limit autoimmune diabetes via an immunoregulatory antimicrobial peptide expressed under the influence of the gut microbiota. Immunity 43, 304–317.

    Article  CAS  PubMed  Google Scholar 

  • Tang, L.Q., Wei, W., Chen, L.M., and Liu, S. (2006). Effects of berberine on diabetes induced by alloxan and a high-fat/high-cholesterol diet in rats. J Ethnopharmacol 108, 109–115.

    Article  CAS  PubMed  Google Scholar 

  • The Lancet. Ageing in China: a ticking bomb. (2016}). The Lancet 388, 2058

  • Thomson Reuters. Essential Science Indicators. https://doi.org/esi.incites.thomsonreuters.com/, 2017-06-23.

  • Thomson Reuters. Journal Citation Report. https://doi.org/jcr.incites.thomsonreuters.com/JCRJournalHomeAction.action, 2016-08-24.

  • UNESCO Institute for Statistics. UNESCO eAtlas of Research and Experimental Development. https://doi.org/www.tellmaps.com/uis/rd/#!/topic/RD, 2017-04-04.

  • Van Noorden, R. (2016). China by the numbers. Nature 534, 452–453.

    Article  PubMed  Google Scholar 

  • Wang, C., Fang, Q., Zhang, R., Lin, X., and Xiang, K. (2004). Scanning for MODY5 gene mutations in Chinese early onset or multiple affected diabetes pedigrees. Acta Diabetol 41, 137–145.

    Article  CAS  PubMed  Google Scholar 

  • Wang, F.H., Liang, Y.B., Zhang, F., Wang, J.J., Wei, W.B., Tao, Q.S., Sun, L.P., Friedman, D.S., Wang, N.L., and Wong, T.Y. (2009). Prevalence of diabetic retinopathy in rural China: the Handan Eye Study. Ophthalmology 116, 461–467.

    Article  PubMed  Google Scholar 

  • Wang, G., Liu, J., Yang, N., Gao, X., Fan, H., Xu, Y., and Yang, W. (2014). MARCH2: comparative assessment of therapeutic effects of acarbose and metformin in newly diagnosed type 2 diabetes patients. PLoS ONE 9, e105698.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Wang, L., Gao, P., Zhang, M., Huang, Z., Zhang, D., Deng, Q., Li, Y., Zhao, Z., Qin, X., Jin, D., et al. (2017). Prevalence and ethnic pattern of diabetes and prediabetes in China in 2013. JAMA 317, 2515.

    Article  PubMed  PubMed Central  Google Scholar 

  • Wang, W., Fu, C.W., Pan, C.Y., Chen, W., Zhan, S., Luan, R., Tan, A., Liu, Z., and Xu, B. (2009). How do type 2 diabetes mellitus-related chronic complications impact direct medical cost in four major cities of urban China? Value Health 12, 923–929.

    Article  PubMed  Google Scholar 

  • Wang, W., Fu, C., Zhuo, H., Luo, J., and Xu, B. (2010). Factors affecting costs and utilization of type 2 diabetes healthcare: a cross-sectional survey among 15 hospitals in urban China. BMC Health Serv Res 10, 244.

    Article  PubMed  PubMed Central  Google Scholar 

  • Wang, X.H., Qian, R.Z., Zhang, W., Chen, S.F., Jin, H.M., and Hu, R.M. (2009). microRNA-320 expression in myocardial microvascular endothelial cells and its relationship with insulin-like growth factor-1 in type 2 diabetic rats. Clin Exp Pharmacol Physiol 36, 181–188.

    Article  CAS  PubMed  Google Scholar 

  • Wei, Y., Yang, H., Zhu, W., Yang, H., Li, H., Yan, J., and Zhang, C. (2014). International Association of Diabetes and Pregnancy Study Group criteria is suitable for gestational diabetes mellitus diagnosis: further evidence from China. Chin Med J (Engl) 127, 3553–3556.

    Google Scholar 

  • Weng, J.P., and Hu, G. (2017). Diabetes: leveraging the tipping point of the diabetes pandemic. Diabetes 66, 1461–1463.

    Article  CAS  PubMed  Google Scholar 

  • Weng, J., Li, Y., Xu, W., Shi, L., Zhang, Q., Zhu, D., Hu, Y., Zhou, Z., Yan, X., Tian, H., et al. (2008). Effect of intensive insulin therapy on β-cell function and glycaemic control in patients with newly diagnosed type 2 diabetes: a multicentre randomised parallel-group trial. Lancet 371, 1753–1760.

    Article  CAS  PubMed  Google Scholar 

  • Weng, J., Retnakaran, R., Ariachery C, A., Ji, L., Meneghini, L., Yang, W., and Woo, J.T. (2015). Short-term intensive insulin therapy at diagnosis in type 2 diabetes: plan for filling the gaps. Diabetes Metab Res Rev 31, 537–544.

    Article  PubMed  Google Scholar 

  • Wu, X.K., Stener-Victorin, E., Kuang, H.Y., Ma, H.L., Gao, J.S., Xie, L.Z., Hou, L.H., Hu, Z.X., Shao, X.G., Ge, J., et al. (2017). Effect of acupuncture and clomiphene in chinese women with polycystic ovary syndrome. JAMA 317, 2502–2514.

    Article  PubMed  PubMed Central  Google Scholar 

  • Wu, Y., Li, H., Loos, R.J.F., Yu, Z., Ye, X., Chen, L., Pan, A., Hu, F.B., and Lin, X. (2008). Common variants in cdkal1, cdkn2a/b, igf2bp2, slc30a8, and hhex/ide genes are associated with type 2 diabetes and impaired fasting glucose in a Chinese Han population. Diabetes 57, 2834–2842.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Xiang, K., Wang, Y., Zheng, T., Jia, W., Li, J., Chen, L., Shen, K., Wu, S., Lin, X., Zhang, G., et al. (2004). Genome-wide search for type 2 diabetes/impaired glucose homeostasis susceptibility genes in the chinese: significant linkage to chromosome 6q21-q23 and chromosome 1q21- q24. Diabetes 53, 228–234.

    Article  CAS  PubMed  Google Scholar 

  • Xie, X.W., Xu, L., Wang, Y.X., and Jonas, J.B. (2008). Prevalence and associated factors of diabetic retinopathy. The Beijing Eye Study 2006. Graefes Arch Clin Exp Ophthalmol 246, 1519–1526.

    PubMed  Google Scholar 

  • Xu, F., Li, Z., Zheng, X., Liu, H., Liang, H., Xu, H., Chen, Z., Zeng, K., and Weng, J. (2014). SIRT1 mediates the effect of GLP-1 receptor agonist exenatide on ameliorating hepatic steatosis. Diabetes 63, 3637–3646.

    Article  CAS  PubMed  Google Scholar 

  • Xu, J.Y., Dan, Q.H., Chan, V., Wat, N.M.S., Tam, S., Tiu, S.C., Lee, K.F., Siu, S.C., Tsang, M.W., Fung, L.M., et al. (2005). Genetic and clinical characteristics of maturity-onset diabetes of the young in Chinese patients. Eur J Hum Genet 13, 422–427.

    Article  CAS  PubMed  Google Scholar 

  • Xu, W., Bi, Y., Sun, Z., Li, J., Guo, L., Yang, T., Wu, G., Shi, L., Feng, Z., Qiu, L., et al. (2015). Comparison of the effects on glycaemic control and β-cell function in newly diagnosed type 2 diabetes patients of treatment with exenatide, insulin or pioglitazone: a multicentre randomized parallel-group trial (the CONFIDENCE study). J Intern Med 277, 137–150.

    Article  CAS  PubMed  Google Scholar 

  • Xu, W., Li, Y., Deng, W., Hao, Y., and Weng, J. (2009). Remission of hyperglycemia following intensive insulin therapy in newly diagnosed type 2 diabetic patients: a long-term follow-up study. Chin Med J (Engl) 122, 2554–2559.

    CAS  Google Scholar 

  • Xu, Y., Wang, L., He, J., Bi, Y., Li, M., Wang, T., Wang, L., Jiang, Y., Dai, M., Lu, J., et al. (2013). Prevalence and control of diabetes in Chinese adults. JAMA 310, 948.

    Article  CAS  PubMed  Google Scholar 

  • Yan, H., Tang, L., Chen, T., Kral, J.G., Jiang, L., Li, Y., Hu, R., Cui, J., Li, S., and Tian, F. (2013). Defining and predicting complete remission of type 2 diabetes: a short-term efficacy study of open gastric bypass. Obes Facts 6, 176–184.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Yang, H., Wei, Y., Gao, X., Xu, X., Fan, L., He, J., Hu, Y., Liu, X., Chen, X., Yang, Z., et al. (2009). Risk factors for gestational diabetes mellitus in Chinese women-a prospective study of 16,286 pregnant women in China. Diabetic Med 26, 1099–1104.

    Article  CAS  PubMed  Google Scholar 

  • Yang, J., Wang, C., Cao, G., Yang, W., Yu, S., Zhai, H., and Pan, Y. (2015). Long-term effects of laparoscopic sleeve gastrectomy versus roux-en-Y gastric bypass for the treatment of Chinese type 2 diabetes mellitus patients with body mass index 28–35 kg/m2. BMC Surg 15, 88.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Yang, L., Christensen, T., Sun, F., and Chang, J. (2012). Cost-effectiveness of switching patients with type 2 diabetes from insulin glargine to insulin detemir in Chinese setting: a health economic model based on the PREDICTIVE study. Value Health 15, S56–S59.

    Article  PubMed  Google Scholar 

  • Yang, W., Chen, L., Ji, Q., Liu, X., Ma, J., Tandon, N., Bhattacharyya, A., Kumar, A., Kim, K.W., Yoon, K.H., et al. (2011). Liraglutide provides similar glycaemic control as glimepiride (both in combination with metformin) and reduces body weight and systolic blood pressure in Asian population with type 2 diabetes from China, South Korea and India: a 16-week, randomized, doubl. Diabetes Obesity Metab 13, 81–88.

    Article  CAS  Google Scholar 

  • Yang, W., Liu, J., Shan, Z., Tian, H., Zhou, Z., Ji, Q., Weng, J., Jia, W., Lu, J., Liu, J., et al. (2014). Acarbose compared with metformin as initial therapy in patients with newly diagnosed type 2 diabetes: an open-label, non-inferiority randomised trial. Lancet Diabetes Endocrinol 2, 46–55.

    Article  CAS  PubMed  Google Scholar 

  • Yang, W., Lu, J., Weng, J., Jia, W., Ji, L., Xiao, J., Shan, Z., Liu, J., Tian, H., Ji, Q., et al. (2010). Prevalence of diabetes among men and women in China. N Engl J Med 362, 1090–1101.

    Article  CAS  PubMed  Google Scholar 

  • Yang, W., Zhao, W., Xiao, J., Li, R., Zhang, P., Kissimova-Skarbek, K., Schneider, E., Jia, W., Ji, L., Guo, X., et al. (2012). Medical care and payment for diabetes in China: enormous threat and great opportunity. PLoS ONE 7, e39513.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Yang, Z., Wang, K., Li, T., Sun, W., Li, Y., Chang, Y.F., Dorman, J.S., and LaPorte, R.E. (1998). Childhood diabetes in China. Enormous variation by place and ethnic group. Diabetes Care 21, 525–529.

    CAS  PubMed  Google Scholar 

  • Yang, Z., Wu, S., Zheng, T., Lu, H., and Xiang, K. (2006). Identification of four novel mutations in the HNF-1A gene in Chinese early-onset and/or multiplex diabetes pedigrees. Chin Med J (Engl) 119, 1072–1078.

    Article  CAS  Google Scholar 

  • Yin, J., Xing, H., and Ye, J. (2008). Efficacy of berberine in patients with type 2 diabetes mellitus. Metabolism 57, 712–717.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Yu, H., Di, J., Bao, Y., Zhang, P., Zhang, L., Tu, Y., Han, X., and Jia, W. (2015). Visceral fat area as a new predictor of short-term diabetes remission after Roux-en-Y gastric bypass surgery in Chinese patients with a body mass index less than 35 kg/m2. Surgery Obesity Related Dis 11, 6–11.

    Article  Google Scholar 

  • Zhang, F., Dong, L., Zhang, C.P., Li, B., Wen, J., Gao, W., Sun, S., Lv, F., Tian, H., Tuomilehto, J., et al. (2011). Increasing prevalence of gestational diabetes mellitus in Chinese women from 1999 to 2008. Diabetic Med 28, 652–657.

    Article  CAS  PubMed  Google Scholar 

  • Zhang, H., Wei, J., Xue, R., Wu, J.D., Zhao, W., Wang, Z.Z., Wang, S.K., Zhou, Z.X., Song, D.Q., Wang, Y.M., et al. (2009). Berberine lowers blood glucose in type 2 diabetes mellitus patients through increasing insulin receptor expression. Metabolism 59, 285–292.

    Article  CAS  PubMed  Google Scholar 

  • Zhang, J., and Chaaban, J. (2013). The economic cost of physical inactivity in China. Prevent Med 56, 75–78.

    Article  Google Scholar 

  • Zhang, L., Wang, Z., Qian, D., and Ni, J. (2014). Effects of changes in health insurance reimbursement level on outpatient service utilization of rural diabetics: evidence from Jiangsu Province, China. BMC Health Serv Res 14, 185.

    Article  PubMed  PubMed Central  Google Scholar 

  • Zhang, M., Lv, X.Y., Li, J., Xu, Z.G., and Chen, L. (2008). The characterization of high-fat diet and multiple low-dose streptozotocin induced type 2 diabetes rat model. Exp Diabetes Res 2008, 1–9.

    Article  CAS  Google Scholar 

  • Zhang, Y., Li, R., Meng, Y., Li, S., Donelan, W., Zhao, Y., Qi, L., Zhang, M., Wang, X., Cui, T., et al. (2014). Irisin stimulates browning of white adipocytes through mitogen-activated protein kinase p38 MAP kinase and ERK MAP kinase signaling. Diabetes 63, 514–525.

    Article  CAS  PubMed  Google Scholar 

  • Zhang, Y., Li, X., Zou, D., Liu, W., Yang, J., Zhu, N., Huo, L., Wang, M., Hong, J., Wu, P., et al. (2008). Treatment of type 2 diabetes and dyslipidemia with the natural plant alkaloid berberine. J Clin Endocrinol Metab 93, 2559–2565.

    Article  CAS  PubMed  Google Scholar 

  • Zhao, W., Zhai, Y., Hu, J., Wang, J., Yang, Z., Kong, L., and Chen, C. (2008). Economic burden of obesity-related chronic diseases in Mainland China. Obesity Rev 9, 62–67.

    Article  Google Scholar 

  • Zhao, X., Guo, L., Yuan, M., He, X., Lin, Y., Gu, C., Li, Q., Zhao, L., and Tong, X. (2016). Growing trend of China's contribution to global diabetes research. Medicine 95, e3517.

  • Zhong, X.L. (1982). Diabetes mellitus survey in China. Chin Med J 95, 423.

    CAS  PubMed  Google Scholar 

  • Zhou, J., Li, H., Ran, X., Yang, W., Li, Q., Peng, Y., Li, Y., Gao, X., Luan, X., and Wang, W. (2011). Establishment of normal reference ranges for glycemic variability in Chinese subjects using continuous glucose monitoring. Med Sci Monit 17, CR9.

    PubMed  PubMed Central  Google Scholar 

  • Zhou, J., Li, H., Ran, X., Yang, W., Li, Q., Peng, Y., Li, Y., Gao, X., Luan, X., Wang, W., et al. (2009). Reference values for continuous glucose monitoring in Chinese subjects. Diabetes Care 32, 1188–1193.

    Article  PubMed  PubMed Central  Google Scholar 

  • Zhou, J., Lv, X., Mu, Y., Wang, X., Li, J., Zhang, X., Wu, J., Bao, Y., and Jia, W. (2012). The accuracy and efficacy of real-time continuous glucose monitoring sensor in Chinese diabetes patients: a multicenter study. Diabetes Tech Therapeut 14, 710–718.

    Article  CAS  Google Scholar 

  • Zhu, L., Mo, Z., Yang, X., Liu, S., Wang, G., Li, P., Tan, J., Ye, F., Strain, J., Im, I., et al. (2012). Effect of laparoscopic Roux-en-Y gastroenterostomy with BMI <35 kg/m2 in type 2 diabetes mellitus. Obes Surg 22, 1562–1567.

    Article  PubMed  Google Scholar 

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Acknowledgements

We thank Yang Zhang from School of Information Management, Sun Yat-Sen University; Xuyu Zhou from Sun Yat-Sen University Library; Daoyuan Wang from AME Publishing Company; Wenbin Yang and Ling Tong from Sanofi Aventis for their contribution in suggestion on methodology. This work was supported by the National Key Research and Development Program of China (2017YFC1309600) and the National Health and Family Planning Commission Foundation for Public Welfare Industry Research Project (201502011).

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  1. Department of Endocrinology and Metabolism, Guangdong Provincial Key Laboratory of Diabetology, The Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, 510630, China

    Zekai Wu & Jianping Weng

  2. Department of Physiology, University of Toronto, Toronto, ON, M5S 1A8, Canada

    Tianru Jin

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  1. Zekai Wu
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Correspondence to Jianping Weng.

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Wu, Z., Jin, T. & Weng, J. A thorough analysis of diabetes research in China from 1995 to 2015: current scenario and future scope. Sci. China Life Sci. 62, 46–62 (2019). https://doi.org/10.1007/s11427-018-9377-y

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