Skip to main content
SpringerLink
Log in

Construction of MoS2 field effect transistor sensor array for the detection of bladder cancer biomarkers

  • Articles
  • Published:
Science China Chemistry Aims and scope Submit manuscript

Abstract

Bladder cancer is one of the commonest malignant tumors of urinary system with high recurrence. However, currently developed bladder cancer urine diagnosis methods are hindered by the low detection sensitivity and accuracy. Herein, a molybdenum disulfide (MoS2) nanosheets-based field effect transistor (FET) sensor array was constructed for simultaneous detection of multiple bladder cancer biomarkers in human urine. With the excellent electronic property of MoS2 and the high specific identification capability of recognition molecules, the proposed biosensor array could simultaneously detect nuclear matrix protein 22 (NMP22) and cytokeratin 8 (CK8) with a wide linear range of 10−6−10−1 pg mL−1 and an ultra-low detection limit of 0.027 and 0.019 aM, respectively. Furthermore, this highly sensitive and specific MoS2 FET sensor array could be used to identify bladder cancer biomarkers from human urine samples. This designed high-performance biosensor array shows great potential in the future diagnosis of bladder cancer.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Frantzi M, van Kessel KE, Zwarthoff EC, Marquez M, Rava M, Malats N, Merseburger AS, Katafigiotis I, Stravodimos K, Mullen W, Zoidakis J, Makridakis M, Pejchinovski M, Critselis E, Lichtinghagen R, Brand K, Dakna M, Roubelakis MG, Theodorescu D, Vlahou A, Mischak H, Anagnou NP. Clin Cancer Res, 2016, 22: 4077–4086

    Article  CAS  PubMed  Google Scholar 

  2. Burger M, Catto JWF, Dalbagni G, Grossman HB, Herr H, Karakiewicz P, Kassouf W, Kiemeney LA, La Vecchia C, Shariat S, Lotan Y. Eur Urology, 2013, 63: 234–241

    Article  Google Scholar 

  3. Xiao SH, Wang JF, Xiao N. Int J Biol Markers, 2016, 31: e276–e285

    Article  CAS  PubMed  Google Scholar 

  4. Pasikanti KK, Esuvaranathan K, Ho PC, Mahendran R, Kamaraj R, Wu QH, Chiong E, Chan ECY. J Proteome Res, 2010, 9: 2988–2995

    Article  CAS  PubMed  Google Scholar 

  5. Li N, Wang Y, Li Y, Cao W, Ma H, Wu D, Du B, Wei Q. Sensor Actuat B-Chem, 2014, 202: 67–73

    Article  CAS  Google Scholar 

  6. Parikh AR, Leshchiner I, Elagina L, Goyal L, Levovitz C, Siravegna G, Livitz D, Rhrissorrakrai K, Martin EE, van Seventer EE, Hanna M, Slowik K, Utro F, Pinto CJ, Wong A, Danysh BP, de la Cruz FF, Fetter IJ, Nadres B, Shahzade HA, Allen JN, Blaszkowsky LS, Clark JW, Giantonio B, Murphy JE, Nipp RD, Roeland E, Ryan DP, Weekes CD, Kwak EL, Faris JE, Wo JY, Aguet F, Dey-Guha I, Hazar-Rethinam M, Dias-Santagata D, Ting DT, Zhu AX, Hong TS, Golub TR, Iafrate AJ, Adalsteinsson VA, Bardelli A, Parida L, Juric D, Getz G, Corcoran RB. Nat Med, 2019, 25: 1415–1421

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  7. Christensen E, Birkenkamp-Demtröder K, Nordentoft I, Høyer S, van der Keur K, van Kessel K, Zwarthoff E, Agerbæk M, Ørntoft TF, Jensen JB, Dyrskjøt L. Eur Urology, 2017, 71: 961–969

    Article  CAS  Google Scholar 

  8. Costa VL, Henrique R, Danielsen SA, Duarte-Pereira S, Eknaes M, Skotheim RI, Rodrigues A, Magalhães JS, Oliveira J, Lothe RA, Teixeira MR, Jerónimo C, Lind GE. Clin Cancer Res, 2010, 16: 5842–5851

    Article  CAS  PubMed  Google Scholar 

  9. Yoshioka Y, Kosaka N, Konishi Y, Ohta H, Okamoto H, Sonoda H, Nonaka R, Yamamoto H, Ishii H, Mori M, Furuta K, Nakajima T, Hayashi H, Sugisaki H, Higashimoto H, Kato T, Takeshita F, Ochiya T. Nat Commun, 2014, 5: 3591

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  10. Miller AM, Shah RH, Pentsova EI, Pourmaleki M, Briggs S, Distefano N, Zheng Y, Skakodub A, Mehta SA, Campos C, Hsieh WY, Selcuklu SD, Ling L, Meng F, Jing X, Samoila A, Bale TA, Tsui DWY, Grommes C, Viale A, Souweidane MM, Tabar V, Brennan CW, Reiner AS, Rosenblum M, Panageas KS, DeAngelis LM, Young RJ, Berger MF, Mellinghoff IK. Nature, 2019, 565: 654–658

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  11. Liu Q, Liu Y, Wu F, Cao X, Li Z, Alharbi M, Abbas AN, Amer MR, Zhou C. ACS Nano, 2018, 12: 1170–1178

    Article  CAS  PubMed  Google Scholar 

  12. Wood SL, Knowles MA, Thompson D, Selby PJ, Banks RE. Nat Rev Urol, 3013, 10: 206–218

    Article  CAS  Google Scholar 

  13. Liang LG, Kong MQ, Zhou S, Sheng YF, Wang P, Yu T, Inci F, Kuo WP, Li LJ, Demirci U, Wang SQ. Sci Rep, 2017, 7: 46224

    Article  PubMed  PubMed Central  Google Scholar 

  14. Goodison S, Rosser CJ, Urquidi V. Mol Diagn Ther, 2013, 17: 71–84

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  15. Dey P. Clinica Chim Acta, 2004, 340: 57–65

    Article  CAS  Google Scholar 

  16. Zhuang Y, Zhang M, Chen B, Duan R, Min X, Zhang Z, Zheng F, Liang H, Zhao Z, Lou X, Xia F. Anal Chem, 2015, 87: 9487–9493

    Article  CAS  PubMed  Google Scholar 

  17. Wang J, Zhang J, Li T, Shen R, Li G, Ling L. Biosens Bioelectron, 2019, 131: 143–148

    Article  CAS  PubMed  Google Scholar 

  18. Arya SK, Estrela P. Biosens Bioelectron, 2018, 117: 620–627

    Article  CAS  PubMed  Google Scholar 

  19. Wu D, Wang Y, Zhang Y, Ma H, Yan T, Du B, Wei Q. Sci Rep, 2016, 6: 24551

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  20. Lin Q, Li Z, Yuan Q. Chin Chem Lett, 2019, 30: 1547–1556

    Article  CAS  Google Scholar 

  21. Ma H, Zhang X, Li X, Li R, Du B, Wei Q. Talanta, 2015, 143: 77–82

    Article  CAS  PubMed  Google Scholar 

  22. Lee MH, Thomas JL, Chang YC, Tsai YS, Liu BD, Lin HY. Biosens Bioelectron, 2016, 79: 789–795

    Article  PubMed  CAS  Google Scholar 

  23. Tan C, Cao X, Wu XJ, He Q, Yang J, Zhang X, Chen J, Zhao W, Han S, Nam GH, Sindoro M, Zhang H. Chem Rev, 2017, 117: 6225–6331

    Article  CAS  PubMed  Google Scholar 

  24. Zhang A, Lieber CM. Chem Rev, 2016, 116: 215–257

    Article  CAS  PubMed  Google Scholar 

  25. Allen B, Kichambare P, Star A. Adv Mater, 2007, 19: 1439–1451

    Article  CAS  Google Scholar 

  26. Li BR, Hsieh YJ, Chen YX, Chung YT, Pan CY, Chen YT. J Am Chem Soc, 2013, 135: 16034–16037

    Article  CAS  PubMed  Google Scholar 

  27. Yang Y, Yang X, Zou X, Wu S, Wan D, Cao A, Liao L, Yuan Q, Duan X. Adv Funct Mater, 2017, 27: 1604096

    Article  CAS  Google Scholar 

  28. Sarkar D, Liu W, Xie X, Anselmo AC, Mitragotri S, Banerjee K. ACS Nano, 2014, 8: 3992–4003

    Article  CAS  PubMed  Google Scholar 

  29. Zhang S, Xu H, Liao F, Sun Y, Ba K, Sun Z, Qiu ZJ, Xu Z, Zhu H, Chen L, Sun Q, Zhou P, Bao W, Zhang DW. Nanotechnology, 2019, 30: 174002

    Article  CAS  PubMed  Google Scholar 

  30. van der Zande AM, Huang PY, Chenet DA, Berkelbach TC, You YM, Lee GH, Heinz TF, Reichman DR, Muller DA, Hone JC. Nat Mater, 2013, 12: 554–561

    Article  CAS  PubMed  Google Scholar 

  31. Chen W, Zhao J, Zhang J, Gu L, Yang Z, Li X, Yu H, Zhu X, Yang R, Shi D, Lin X, Guo J, Bai X, Zhang G. J Am Chem Soc, 2015, 137: 15632–15635

    Article  CAS  PubMed  Google Scholar 

  32. Ahmad R, Tripathy N, Park JH, Hahn YB. Chem Commun, 2015, 51: 11968–11971

    Article  CAS  Google Scholar 

  33. Naylor CH, Kybert NJ, Schneier C, Xi J, Romero G, Saven JG, Liu R, Johnson ATC. ACS Nano, 2016, 10: 6173–6179

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  34. Chen M, Nam H, Rokni H, Wi S, Yoon JS, Chen P, Kurabayashi K, Lu W, Liang X. ACS Nano, 2015, 9: 8773–8785

    Article  CAS  PubMed  Google Scholar 

  35. Duan R, Zhang Z, Zheng F, Wang L, Guo J, Zhang T, Dai X, Zhang S, Yang D, Kuang R, Wang G, He C, Hakeem A, Shu C, Yin P, Lou X, Zeng F, Liang H, Xia F. ACS Appl Mater Interfaces, 2017, 9: 23420–23427

    Article  CAS  PubMed  Google Scholar 

  36. Jeon J, Jang SK, Jeon SM, Yoo G, Jang YH, Park JH, Lee S. Nanoscale, 2015, 7: 1688–1695

    Article  CAS  PubMed  Google Scholar 

  37. Huang Y, Guo J, Kang Y, Ai Y, Li CM. Nanoscale, 2015, 7: 19358–19376

    Article  CAS  PubMed  Google Scholar 

  38. Shan J, Li J, Chu X, Xu M, Jin F, Wang X, Ma L, Fang X, Wei Z, Wang X. RSC Adv, 2018, 8: 7942–7948

    Article  CAS  Google Scholar 

  39. Zhou G, Chang J, Pu H, Shi K, Mao S, Sui X, Ren R, Cui S, Chen J. ACS Sens, 2016, 1: 295–302

    Article  CAS  Google Scholar 

  40. Lee DW, Lee J, Sohn IY, Kim BY, Son YM, Bark H, Jung J, Choi M, Kim TH, Lee C, Lee NE. Nano Res, 2015, 8: 2340–2350

    Article  CAS  Google Scholar 

  41. Ren X, Ma H, Zhang T, Zhang Y, Yan T, Du B, Wei Q. ACS Appl Mater Interfaces, 2017, 9: 37637–37644

    Article  CAS  PubMed  Google Scholar 

  42. Sánchez-Carbayo M, Urrutia M, Silva JM, Romaní R, García J, Alférez F, González deBuitrago JM, Navajo JA. Urology, 2000, 55: 526–532

    Article  PubMed  Google Scholar 

  43. Park H, Han G, Lee SW, Lee H, Jeong SH, Naqi M, AlMutairi AA, Kim YJ, Lee J, Kim W, Kim S, Yoon Y, Yoo G. ACS Appl Mater Interfaces, 2017, 9: 43490–43497

    Article  CAS  PubMed  Google Scholar 

  44. Gong X, Liu Y, Xiang H, Liu H, Liu Z, Zhao X, Li J, Li H, Hong G, Hu TS, Chen H, Liu S, Yu G. Sci China Mater, 2019, 62: 1479–1487

    Article  CAS  Google Scholar 

  45. Zhou BF, Wei JH, Chen ZH, Dong P, Lai YR, Fang Y, Jiang HM, Lu J, Zhou FJ, Xie D, Luo JH, Chen W. Oncotarget, 2016, 7: 41703–41714

    Article  PubMed  PubMed Central  Google Scholar 

  46. Kibar Y, Goktas S, Kilic S, Yaman H, Onguru O, Peker AF. Ann Clin Lab Sci, 2006, 36: 31–38

    CAS  PubMed  Google Scholar 

Download references

Acknowledgements

This work was supported by the National Key Research and Development Program of China (2017YFA0208000), the National Natural Science Foundation of China (21925401, 21904033, 21675120), and Changsha Municipal Science and Technology Projects, China (kq1901030).

Author information

Author notes

  1. These authors contributed equally to this work.

Authors and Affiliations

  1. Key Laboratory of Analytical Chemistry for Biology and Medicine (Ministry of Education), College of Chemistry and Molecular Sciences, Wuhan University, Wuhan, 430072, China

    Yujie Yang, Bo Zeng, Yingxue Li, Yanbing Yang & Quan Yuan

  2. Institute of Chemical Biology and Nanomedicine, State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, Hunan University, Changsha, 410082, China

    Yanbing Yang & Quan Yuan

  3. Department of Urology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China

    Huageng Liang

  4. Key Laboratory for Micro-/Nano-Optoelectronic Devices of Ministry of Education, School of Physics and Electronics, Hunan University, Changsha, 410082, China

    Yanbing Yang

Authors
  1. Yujie Yang
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Bo Zeng
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Yingxue Li
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Huageng Liang
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Yanbing Yang
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Quan Yuan
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding authors

Correspondence to Yanbing Yang or Quan Yuan.

Ethics declarations

Conflict of interest The authors declare that they have no conflict of interest.

Supporting information

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Yang, Y., Zeng, B., Li, Y. et al. Construction of MoS2 field effect transistor sensor array for the detection of bladder cancer biomarkers. Sci. China Chem. 63, 997–1003 (2020). https://doi.org/10.1007/s11426-020-9743-2

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s11426-020-9743-2

Keywords

Search

Navigation