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Cryptadine C, a new C27N3-type Lycopodium alkaloid from Lycopodium cryptomerinum

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Abstract

A new C27N3-type Lycopodium alkaloid consisting of two decahydroquinolines and a piperidine, cryptadine C (1) was isolated from Lycopodium cryptomerinum. The structure and relative configuration of 1, which is related to those of cryptadines A and B, lycoperine A, and hupercumine A, was elucidated on the basis of spectroscopic data. Cryptadine C showed moderate inhibitory activity against acetylcholinesterase.

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Acknowledgements

This work was partly supported by JSPS KAKENHI (JP 22K06671 to MH) and (JP 22K06685 to YH), Japan.

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Authors and Affiliations

  1. Faculty of Pharmaceutical Sciences, Hoshi University, Ebara 2-4-41 Shinagawa-Ku, Tokyo, 142-8501, Japan

    Yusuke Hirasawa, Rina Hattori, Manami Ohtani & Hiroshi Morita

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  1. Yusuke Hirasawa
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  2. Rina Hattori
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  3. Manami Ohtani
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  4. Hiroshi Morita
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Correspondence to Yusuke Hirasawa or Hiroshi Morita.

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Hirasawa, Y., Hattori, R., Ohtani, M. et al. Cryptadine C, a new C27N3-type Lycopodium alkaloid from Lycopodium cryptomerinum. J Nat Med 77, 610–613 (2023). https://doi.org/10.1007/s11418-023-01707-9

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  • DOI: https://doi.org/10.1007/s11418-023-01707-9

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