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Two new xanthones from the roots of Cratoxylum cochinchinense and their cytotoxicity

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A Correction to this article was published on 06 February 2020

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Abstract

Two new xanthones namely cratochinone A (1) and cratochinone B (2), along with 16 known xanthones, were isolated from the roots of Cratoxylum cochinchinense. Their structures were characterized by spectroscopic methods, especially 1D and 2D NMR as well as comparison with those reported in the literature for known xanthones. All isolated compounds were evaluated for their cytotoxicity against five human cancer cell lines (KB, HeLa S-3, HT-29, MCF-7 and Hep G2 cell lines). Compounds 2, 5, and 7 showed significant cytotoxic effects against all cell lines with IC50 values in the range of 0.91–9.93 μM, while 10 exhibited cytotoxicity against the KB, HeLa S-3, and HT-29 cells with IC50 values of 7.39, 6.07, and 8.11 μM, respectively. Compound 12 exhibited cytotoxicity against both KB and HeLa S-3 cells with IC50 values of 7.28 and 9.84 μM.

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Fig. 1
Fig. 2

Change history

  • 06 February 2020

    In the original publication of the article, figure 1 was published incorrectly. The correct version of figure 1 is provided below,

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Acknowledgements

The authors are grateful to the 90th anniversary of Chulalongkorn University Fund (Rat-chadaphisek-somphot Endowment Fund) for financial support. We also thank Dr. Suttira Sedlak, Walai Rukhavej Botanical Research Institute, Mahasarakham University, Mahasarakham 44000, Thailand for identification and deposition of the plant material.

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Authors and Affiliations

  1. Center of Excellence in Natural Products Chemistry, Department of Chemistry, Faculty of Science, Chulalongkorn University, Bangkok, 10330, Thailand

    Peeravat Natrsanga & Santi Tip-pyang

  2. Department of Chemistry, Faculty of Science, Burapha University, Chonburi, 20321, Thailand

    Jongkolnee Jongaramruong

  3. Natural Products Research Section, Research Division, National Cancer Institute, Bangkok, 10400, Thailand

    Kitiya Rassamee & Pongpun Siripong

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  1. Peeravat Natrsanga
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  2. Jongkolnee Jongaramruong
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  3. Kitiya Rassamee
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  4. Pongpun Siripong
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  5. Santi Tip-pyang
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Correspondence to Santi Tip-pyang.

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The original version of this article was revised. Figure 1 was published incorrectly and corrected in this version.

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Natrsanga, P., Jongaramruong, J., Rassamee, K. et al. Two new xanthones from the roots of Cratoxylum cochinchinense and their cytotoxicity. J Nat Med 74, 467–473 (2020). https://doi.org/10.1007/s11418-019-01376-7

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