Abstract
Alzheimer’s diseases (AD) and type 2 diabetes (T2D) are two age-related diseases characterized by amyloid fibrillogenesis. Prevention of amyloid aggregation is a promising therapeutic strategy for AD and T2D. Two spermine alkaloids, kukoamines A and B, isolated from Lycii Cortex (LyC) were investigated for their inhibitory effect on amyloid aggregation. Both kukoamines A and B inhibited aggregation of amyloid β (Aβ) and human islet amyloid polypeptide (hIAPP) in a dose-dependent manner. Kukoamine B showed stronger inhibitory activity than kukoamine A. These results on the inhibitory activity of kukoamines A and B on Aβ and hIAPP indicate that the catechol moiety is essential for inhibition of amyloid aggregation.
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Acknowledgements
We are pleased to acknowledge Professor Kazuhiro Irie, Associate Professor Kazuma Murakami, and Dr. Mizuho Hanaki, Graduate School of Agriculture, Kyoto University for preparing Aβ42. We would like to thank Editage (www.editage.jp) for English language editing. This work was partially supported by JSPS KAKENHI grant no. JP24580156.
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Jiang, G., Takase, M., Aihara, Y. et al. Inhibitory activities of kukoamines A and B from Lycii Cortex on amyloid aggregation related to Alzheimer’s disease and type 2 diabetes. J Nat Med 74, 247–251 (2020). https://doi.org/10.1007/s11418-019-01337-0
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DOI: https://doi.org/10.1007/s11418-019-01337-0