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Acylated neo-clerodane type diterpenoids from the aerial parts of Scutellaria coleifolia Levl. (Lamiaceae)

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Abstract

Twenty new neo-clerodane type diterpenoids, scutefolides G1-S (1–20), were isolated from the 70 % aqueous acetone extract of the aerial parts of Scutellaria coleifolia. Their structures were elucidated by extensive spectroscopic analyses. The absolute configurations of 1, 2, 7, 8, 14 and 15 were determined by means of the CD exciton chirality method. Compounds 1, 2, 5, 7, 8, 12, 14, 15, 18 and 19 were evaluated for their cytotoxic activities against four human cancer cell lines, and anti-bacterial activities against methicillin-resistant Staphylococcus aureus.

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Author notes

  1. Shin-ichiro Kurimoto

    Present address: Faculty of Pharmaceutical Sciences, Himeji Dokkyo University, 7-2-1 Kamiohno, Himeji, 6708524, Japan

Authors and Affiliations

  1. Graduate School of Pharmaceutical Sciences, Tokushima University, 1-78 Shomachi, Tokushima, 7708505, Japan

    Shin-ichiro Kurimoto, Hirofumi Shibata, Yoshihisa Takaishi & Yoshiki Kashiwada

  2. State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, 650201, People’s Republic of China

    Jian-Xin Pu & Han-Dong Sun

Authors
  1. Shin-ichiro Kurimoto
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  2. Jian-Xin Pu
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  3. Han-Dong Sun
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  4. Hirofumi Shibata
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  5. Yoshihisa Takaishi
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  6. Yoshiki Kashiwada
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Correspondence to Yoshiki Kashiwada.

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Kurimoto, Si., Pu, JX., Sun, HD. et al. Acylated neo-clerodane type diterpenoids from the aerial parts of Scutellaria coleifolia Levl. (Lamiaceae). J Nat Med 70, 241–252 (2016). https://doi.org/10.1007/s11418-016-0967-3

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  • DOI: https://doi.org/10.1007/s11418-016-0967-3

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