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Justidrusamides A–D, new 2-aminobenzyl alcohol derivatives from Justicia gendarussa

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Abstract

Justidrusamides A–D (1–4), four new alkaloids containing 2-aminobenzyl alcohol, succinic acid, and 2,3-dihydroxy-2-(1-hydroxyethyl) butanoic acid skeletons have been isolated from leaves of Justicia gendarussa, and their structures were elucidated using 2D NMR data and chemical means. This is the first report of a 2,3-dihydroxy-2-(1-hydroxyethyl) butanoic acid derivative in nature.

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Acknowledgments

This work was supported by Grants in-Aid for Scientific Research from JSPS.

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Authors and Affiliations

  1. Faculty of Pharmaceutical Sciences, Hoshi University, Ebara 2-4-41 Shinagawa-ku, Tokyo, 142-8501, Japan

    Yuko Kiren, Jun Deguchi, Yusuke Hirasawa & Hiroshi Morita

  2. Department of Pharmacognocy and Phytochemistry, Faculty of Pharmacy, Airlangga University, Jalan Dharmawangsa Dalam, 60286, Surabaya, Indonesia

    Bambang Prajogo

Authors
  1. Yuko Kiren
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  2. Jun Deguchi
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  3. Yusuke Hirasawa
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  4. Hiroshi Morita
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  5. Bambang Prajogo
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Corresponding authors

Correspondence to Hiroshi Morita or Bambang Prajogo.

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Kiren, Y., Deguchi, J., Hirasawa, Y. et al. Justidrusamides A–D, new 2-aminobenzyl alcohol derivatives from Justicia gendarussa . J Nat Med 68, 754–758 (2014). https://doi.org/10.1007/s11418-014-0862-8

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  • DOI: https://doi.org/10.1007/s11418-014-0862-8

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